Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Koen Venken"'
Autor:
Annelore Beterams, Marta Calatayud Arroyo, Kim De Paepe, Ann-Sophie De Craemer, Dirk Elewaut, Koen Venken, Tom Van de Wiele
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Spondyloarthritis is a group of chronic inflammatory diseases that primarily affects axial or peripheral joints and is frequently associated with inflammation at non-articular sites. The disease is multifactorial, involving genetics, immunit
Externí odkaz:
https://doaj.org/article/8e6b47d17c054f97bc04dd0276e85c6b
Autor:
Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel
Externí odkaz:
https://doaj.org/article/ddd72678135941fdb84362715749b1f1
Autor:
Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to h
Externí odkaz:
https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventi
Externí odkaz:
https://doaj.org/article/2170c9a049744114ab34003a56c2be8d
Autor:
Mérédis Favreau, Koen Venken, Sylvia Faict, Ken Maes, Kim De Veirman, Elke De Bruyne, Xavier Leleu, Louis Boon, Dirk Elewaut, Karin Vanderkerken, Eline Menu
Publikováno v:
Haematologica, Vol 102, Iss 7 (2017)
Externí odkaz:
https://doaj.org/article/61ea36d422bd4d2e8922c913559ebcba
Autor:
Donna J Palmer, Nathan C Grove, Jordan Ing, Ana M Crane, Koen Venken, Brian R Davis, Philip Ng
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off-target cleavage. Because of their large cloning capacity of 37 kb, helper-dependent ad
Externí odkaz:
https://doaj.org/article/3ce947c49c044717b64fbc81c88eb461
Autor:
Anton De Spiegeleer, Evelien Wynendaele, Matthias Vandekerckhove, Sofie Stalmans, Maxime Boucart, Nele Van Den Noortgate, Koen Venken, Serge Van Calenbergh, Sandrine Aspeslagh, Dirk Elewaut
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87000 (2014)
Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involv
Externí odkaz:
https://doaj.org/article/eba35615cc5a4d26bc5171cd3d3268a0
Autor:
Céline Mortier, Eric Gracey, Julie Coudenys, Teddy Manuello, Tine Decruy, Margaux Maelegheer, Flore Stappers, Elisabeth Gilis, Djoere Gaublomme, Luc Van Hoorebeke, Sophie Van Welden, Catherine Ambler, Martin Hegen, Peter Symanowicz, Stefan Steyn, Gabriel Berstein, Dirk Elewaut, Koen Venken
Publikováno v:
Rheumatology.
Objective Divergent therapeutic outcomes on different disease domains have been noted with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master regulator of type 17 immune responses, is of potential therapeutic inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510a8e98f043cf9d28bc7fec0adc3be0
https://doi.org/10.1093/rheumatology/kead022
https://doi.org/10.1093/rheumatology/kead022
Autor:
Koen Venken, Matthias Jarlborg, Tine Decruy, Céline Mortier, Carolien Vlieghe, Elisabeth Gilis, Ann-Sophie De Craemer, Julie Coudenys, Isabelle Cambré, Devan Fleury, Alexander Klimowicz, Filip Van den Bosch, Anne Hoorens, Triana Lobaton, Sytze de Roock, Tim Sparwasser, Gerald Nabozny, Peggy Jacques, Dirk Elewaut
Publikováno v:
ANNALS OF THE RHEUMATIC DISEASES
ObjectivesGut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly understood. We the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4100c15148b1d6e0bcd6761594402b48
https://doi.org/10.1136/ard-2022-223757
https://doi.org/10.1136/ard-2022-223757
Publikováno v:
Rheumatic Disease Clinics of North America. 46:213-224
Spondyloarthritis, although primarily a joint-centered disease, is associated with extra-articular features, such as gut inflammation, psoriasis, and/or uveitis. Evidence points to underlying genetic predisposing factors and/or environmental factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6f4c1fa44b02b4cf428aa1a06d95e3
https://doi.org/10.1016/j.rdc.2020.01.007
https://doi.org/10.1016/j.rdc.2020.01.007