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Akademický článek

In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses

Autor: Annelore Beterams, Marta Calatayud Arroyo, Kim De Paepe, Ann-Sophie De Craemer, Dirk Elewaut, Koen Venken, Tom Van de Wiele

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Spondyloarthritis is a group of chronic inflammatory diseases that primarily affects axial or peripheral joints and is frequently associated with inflammation at non-articular sites. The disease is multifactorial, involving genetics, immunit

Externí odkaz: https://doaj.org/article/8e6b47d17c054f97bc04dd0276e85c6b

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Akademický článek

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel

Externí odkaz: https://doaj.org/article/ddd72678135941fdb84362715749b1f1

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Akademický článek

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Autor: Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to h

Externí odkaz: https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1

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RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells

Autor: Céline Mortier, Eric Gracey, Julie Coudenys, Teddy Manuello, Tine Decruy, Margaux Maelegheer, Flore Stappers, Elisabeth Gilis, Djoere Gaublomme, Luc Van Hoorebeke, Sophie Van Welden, Catherine Ambler, Martin Hegen, Peter Symanowicz, Stefan Steyn, Gabriel Berstein, Dirk Elewaut, Koen Venken

Publikováno v: Rheumatology.

Objective Divergent therapeutic outcomes on different disease domains have been noted with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master regulator of type 17 immune responses, is of potential therapeutic inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::510a8e98f043cf9d28bc7fec0adc3be0
https://doi.org/10.1093/rheumatology/kead022

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Akademický článek

It Takes 'Guts' to Cause Joint Inflammation: Role of Innate-Like T Cells

Autor: Céline Mortier, Srinath Govindarajan, Koen Venken, Dirk Elewaut

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventi

Externí odkaz: https://doaj.org/article/2170c9a049744114ab34003a56c2be8d

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Akademický článek

Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition

Autor: Mérédis Favreau, Koen Venken, Sylvia Faict, Ken Maes, Kim De Veirman, Elke De Bruyne, Xavier Leleu, Louis Boon, Dirk Elewaut, Karin Vanderkerken, Eline Menu

Publikováno v: Haematologica, Vol 102, Iss 7 (2017)

Externí odkaz: https://doaj.org/article/61ea36d422bd4d2e8922c913559ebcba

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Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

Autor: Koen Venken, Matthias Jarlborg, Tine Decruy, Céline Mortier, Carolien Vlieghe, Elisabeth Gilis, Ann-Sophie De Craemer, Julie Coudenys, Isabelle Cambré, Devan Fleury, Alexander Klimowicz, Filip Van den Bosch, Anne Hoorens, Triana Lobaton, Sytze de Roock, Tim Sparwasser, Gerald Nabozny, Peggy Jacques, Dirk Elewaut

Publikováno v: ANNALS OF THE RHEUMATIC DISEASES

ObjectivesGut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly understood. We the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4100c15148b1d6e0bcd6761594402b48
https://doi.org/10.1136/ard-2022-223757

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Akademický článek

Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors

Autor: Donna J Palmer, Nathan C Grove, Jordan Ing, Ana M Crane, Koen Venken, Brian R Davis, Philip Ng

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding off-target cleavage. Because of their large cloning capacity of 37 kb, helper-dependent ad

Externí odkaz: https://doaj.org/article/3ce947c49c044717b64fbc81c88eb461

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Intestinal Microbiota, HLA-B27, and Spondyloarthritis

Autor: Dirk Elewaut, Emilie Dumas, James T. Rosenbaum, Koen Venken

Publikováno v: Rheumatic Disease Clinics of North America. 46:213-224

Spondyloarthritis, although primarily a joint-centered disease, is associated with extra-articular features, such as gut inflammation, psoriasis, and/or uveitis. Evidence points to underlying genetic predisposing factors and/or environmental factors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f6f4c1fa44b02b4cf428aa1a06d95e3
https://doi.org/10.1016/j.rdc.2020.01.007

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Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 13

Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d0473efa092881a5a239cda1bba780
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8498

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