Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Koen Vandyck"'
Autor:
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K. Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M. Blatt, Leonid Beigelman, Julian A. Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors to select for drug-resistant variants needs to be establish
Externí odkaz:
https://doaj.org/article/68b3f8dcc3b24cffa15d8cab99c36119
Autor:
Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Sucheta Mukherjee, Caroline Williams, Antitsa Stoycheva, Lawrence M Blatt, Leonid N Beigelman, Julian A Symons, Pierre Raboisson, David McGowan, Koen Vandyck, Jerome Deval
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0240338 (2020)
Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear thyroid hormone receptor (THR). Currently, there are several THRβ agonists in clinical trials fo
Externí odkaz:
https://doaj.org/article/9888716071a5408e90bb5d9370ea3a38
Autor:
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M Blatt, Leonid Beigelman, Julian A Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors to select for drug-resistant variants needs to be established. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36125eb5d31998d4c26e9978f474d0c
https://doi.org/10.1101/2022.06.07.495116
https://doi.org/10.1101/2022.06.07.495116
Autor:
Leonid Beigelman, Jerome Deval, Lawrence M. Blatt, Dorothée Bardiot, Laura Vangeel, Sandro Boland, Johan Neyts, Cheng Liu, Steven Dejonghe, Dinah Misner, Andreas Jekle, Pierre Raboisson, Sushmita Mukherjee Chanda, Vladimir Serebryany, Caroline S. Foo, Koen Vandyck, Arnaud Marchand, Suping Ren, Julian A. Symons, Patrick Chaltin, Kusum Gupta, Antitsa Dimitrova Stoycheva, Dirk Jochmans, Rana Abdelnabi
Publikováno v:
Biochemical and Biophysical Research Communications
There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f364b0af0bca75044f48bf96844cbe8
https://lirias.kuleuven.be/handle/123456789/673810
https://lirias.kuleuven.be/handle/123456789/673810
Autor:
Andreas Jekle, Julian A. Symons, Sushmita Mukherjee Chanda, Vladimir Serebryany, Leonid Beigelman, Cheng Liu, Rana Abdelnabi, Suping Ren, Steven Dejonghe, Sandro Boland, Johan Neyts, Dorothée Bardiot, Dinah Misner, Antitsa Dimitrova Stoycheva, Patrick Chaltin, Jerome Deval, Pierre Raboisson, Kusum Gupta, Koen Vandyck, Dirk Jochmans, Caroline S. Foo, Arnaud Marchand, Lawrence M. Blatt, Laura Vangeel
There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7502a8f400fdb028d390f18fc0e96d
https://doi.org/10.1101/2021.02.14.431129
https://doi.org/10.1101/2021.02.14.431129
Autor:
Koen Vandyck, Jerome Deval
Publikováno v:
Current Opinion in Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro) controls virus replication and is therefore considered a major target and promising opportunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cbc8e83025c56d67c0923603d46d05
https://pubmed.ncbi.nlm.nih.gov/34029993
https://pubmed.ncbi.nlm.nih.gov/34029993
Autor:
Pierre Jean-Marie Bernard Raboisson, Jan Martin Berke, Wendy Mostmans, Karen Vergauwen, Pascale Dehertogh, Frederik Pauwels, Koen Vandyck
Publikováno v:
Antimicrob Agents Chemother
Capsid assembly is a critical step in the hepatitis B virus (HBV) life cycle, mediated by the core protein. Core is a potential target for new antiviral therapies, the capsid assembly modulators (CAMs). JNJ-56136379 (JNJ-6379) is a novel and potent C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f00d6e3cb5fb6cf750c0e63d0e117
https://doi.org/10.1128/aac.02439-19
https://doi.org/10.1128/aac.02439-19
Autor:
Danielle Peeters, Sarah Sauviller, Emmanuel Gustin, Peter Vermeulen, Jan Martin Berke, Dirk Wuyts, Frederik Pauwels, Koen Vandyck, Steffen Jaensch, Karen Vergauwen
Publikováno v:
Journal of Virological Methods. 293:114150
Hepatitis B Virus (HBV) core protein has multiple functions in the viral life cycle and is an attractive target for new anti-viral therapies. Capsid assembly modulators (CAMs) target the core protein and induce the formation of either morphologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0e6c6dae9b7885d2b9f2dff195934
https://doi.org/10.1016/j.jviromet.2021.114150
https://doi.org/10.1016/j.jviromet.2021.114150
Autor:
Koen Vandyck, Patrick Chaltin, Leonid Beigelman, Sandro Boland, Arnaud Marchand, Lawrence M. Blatt, Jerome Deval, Dorothée Bardiot, Michael D. Scholle, Zachary A. Gurard-Levin, Julian Symons, Cheng Liu, Pierre Raboisson
Publikováno v:
Antiviral Research
The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a major target for the discovery of direct antiviral agents. We previously reported the evaluation of SARS-CoV-2 3CLpro i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51d040e14f3147412662ddd00dbbca3
https://doi.org/10.1016/j.antiviral.2021.105020
https://doi.org/10.1016/j.antiviral.2021.105020
Autor:
Tse-I Lin, Lawrence M. Blatt, Andreas Jekle, Dinah Misner, Pierre Jean-Marie Bernard Raboisson, Caroline G. Williams, Koen Vandyck, Sarah K. Stevens, Xuan G. Luong, Kusum Gupta, Leonid Beigelman, Julian A. Symons, Sucheta Mukherjee, Sushmita Mukherjee Chanda, David McGowan, Antitsa Dimitrova Stoycheva, Jerome Deval
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0240338 (2020)
PLoS ONE, Vol 15, Iss 12, p e0240338 (2020)
Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear thyroid hormone receptor (THR). Currently, there are several THRβ agonists in clinical trials fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeec2166a444b3c76a4fe1b2e9f35ed
https://doi.org/10.1371/journal.pone.0240338
https://doi.org/10.1371/journal.pone.0240338