Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Koen Schepers"'
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Akademický článek
Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures
Autor: Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn, Helene Roelofs
Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used to overcome this hurdle, but changing the c
Externí odkaz: https://doaj.org/article/62daa1df1f634a9aa203429cec3a4b11
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2
Akademický článek
In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction.
Autor: Anne Steins, Pieter Dik, Wally H Müller, Stephin J Vervoort, Kerstin Reimers, Jörn W Kuhbier, Peter M Vogt, Aart A van Apeldoorn, Paul J Coffer, Koen Schepers
Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145240 (2015)
Reconstruction of the bladder by means of both natural and synthetic materials remains a challenge due to severe adverse effects such as mechanical failure. Here we investigate the application of spider major ampullate gland-derived dragline silk fro
Externí odkaz: https://doaj.org/article/ab7796a802064861a7b82359d90f77da
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3
A unique immune signature in blood separates therapy-refractory from therapy-responsive acute graft-versus-host disease
Autor: Astrid G. S. van Halteren, Jessica S. Suwandi, Sander Tuit, Jelske Borst, Sandra Laban, Roula Tsonaka, Ada Struijk, Anna-Sophia Wiekmeijer, Melissa van Pel, Bart O. Roep, Jaap Jan Zwaginga, Arjan C. Lankester, Koen Schepers, Maarten J. D. van Tol, Willem E. Fibbe
Publikováno v: Blood. 141(11):1277-1292
Acute graft-versus-host disease (aGVHD) is an immune cell‒driven, potentially lethal complication of allogeneic hematopoietic stem cell transplantation affecting diverse organs, including the skin, liver, and gastrointestinal (GI) tract. We applied
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4806f577f9ab625e12cf2e9aa317027
https://doi.org/10.1182/blood.2022015734
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4
Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures
Autor: Joost D. de Bruijn, Willem E. Fibbe, R. Roosloot, R. Das, M. Driessen, Melissa van Pel, Koen Schepers, Helene Roelofs
Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Background Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used to overcome this hurdle, but changing the culture me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd162aa4fa72e17694e6462b09f2e2e0
https://doi.org/10.1186/s12967-019-1989-x
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5
Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+ Hematopoietic Stem-Progenitor Cells
Autor: Koen Schepers, Jan Jacob Schuringa, Paul J. Coffer, Maria Catalina Gomez-Puerto, Edo Vellenga, Albertus T. J. Wierenga, Hendrik Folkerts
Publikováno v: Stem Cells, 34(6), 1651. AlphaMed Press
STEM CELLS, 34(6), 1651-1663. Wiley-Blackwell
Autophagy is a highly regulated catabolic process that involves sequestration and lysosomal degradation of cytosolic components such as damaged organelles and misfolded proteins. While autophagy can be considered to be a general cellular housekeeping
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6000c3f81d95625b1e3220c0d3316b
https://doi.org/10.1002/stem.2347
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6
The human and murine hematopoietic stem cell niches: are they comparable?
Autor: Koen Schepers, Melissa van Pel, Willem E. Fibbe
Publikováno v: Annals of the New York Academy of Sciences. 1370:55-64
Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self-renewal and their development into all mature cells of the peripheral blood. Progress in this research field has largely been guide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c74526dba1a6306b5141e0befe3fce0e
https://doi.org/10.1111/nyas.12994
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7
The impact of immune response on endochondral bone regeneration
Autor: Alessia Longoni, Debby Gawlitta, Koen Schepers, Antoine J.W.P. Rosenberg, Harrie Weinans, L. Knežević
Publikováno v: Regenerative Medicine, 3(22). Future Medicine Ltd.
npj Regenerative Medicine, Vol 3, Iss 1, Pp 1-11 (2018)
Longoni, A, Knežević, L, Schepers, K, Weinans, H, Rosenberg, A J W P & Gawlitta, D 2018, ' The impact of immune response on endochondral bone regeneration ', npj Regenerative Medicine, vol. 3, 22 . https://doi.org/10.1038/s41536-018-0060-5
NPJ Regenerative Medicine
npj Regenerative Medicine, 3
Tissue engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. Such constructs typically consist of multipotent mesenchymal stromal cells (MSCs) forming a car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836046c6ae8dc88daf553c602c0c009a
https://dspace.library.uu.nl/handle/1874/376426
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8
HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Autor: Sylvain Provot, Koen Schepers, Claire-Sophie Devignes, Amy-Jo Casbon, Audrey Brenot, Stéphanie Fabre, Audrey Devillers, Yetki Aslan, Jonathan Chou, Zena Werb
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 5
Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c24e1c367018eca079cb6089885e21
https://doi.org/10.1073/pnas.1718009115
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10
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
Autor: Timothy B. Campbell, Emmanuelle Passegué, Koen Schepers
Publikováno v: Cell Stem Cell. 16:254-267
Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche to maintain their quiescence and adapt blood production to the organism's needs. Alterations in the BM niche are commonly observed in blood malignancies and dire
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b505d58831444e34e32357eeace118
https://doi.org/10.1016/j.stem.2015.02.014
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