Flow chemistry experiments in the undergraduate teaching laboratory: synthesis of diazo dyes and disulfides

Autor: Wilko M. A. Weggemans, C. Jan A. Verwijlen, Koen P. L. Kuijpers, Timothy Noël

Publikováno v: Journal of Flow Chemistry, 11(1), 7-12. Akadémiai Kiadó
Journal of Flow Chemistry, 11(1), 7-12. Akademiai Kiadó

By embedding flow technology in the early phases of academic education, students are exposed to both the theoretical and practical aspects of this modern and widely-used technology. Herein, two laboratory flow experiments are described which have bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e83fbb1cfd8f999cb227f12646d44b
https://doi.org/10.1007/s41981-020-00118-1

Process intensification of a photochemical oxidation reaction using a Rotor-Stator Spinning Disk Reactor: A strategy for scale up

Autor: Raoul B.J. Hendrix, Jasper Hacking, Timothy Noël, Emma Anna Carolina Emanuelsson, Parimala Shivaprasad, Koen P. L. Kuijpers, John van der Schaaf, Arnab Chaudhuri

Publikováno v: Chemical Engineering Journal, 400:125875. Elsevier

Photochemical transformations have witnessed a remarkable growth of attention in the past decade due to the popularity of photoredox catalysis and the technological progress in energy-efficient light sources. However, the scaling of these photon-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f31d75335ce10087ae4b1b3e2c1ff67
https://research.tue.nl/en/publications/43f60aa4-205e-4e7c-9d3c-48c922d45479

A Fully Automated Continuous-Flow Platform for Fluorescence Quenching Studies and Stern-Volmer Analysis

Autor: Cecilia Bottecchia, Timothy Noël, Koen P. L. Kuijpers, Dario Cambié, Koen Drummen, Niels J. König

Publikováno v: Angewandte Chemie-International Edition, 57(35), 11278-11282. Wiley
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition

Herein, we report the first fully automated continuous‐flow platform for fluorescence quenching studies and Stern–Volmer analysis. All the components of the platform were automated and controlled by a self‐written Python script. A user‐friend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a1218e8627401de77a508f1592ed99
https://doi.org/10.1002/anie.201805632

Visible light-induced trifluoromethylation and perfluoroalkylation of cysteine residues in batch and continuous flow

Autor: Koen P. L. Kuijpers, Xiao-Jing Wei, Timothy Noël, Volker Hessel, Cecilia Bottecchia

Publikováno v: Journal of Organic Chemistry, 81(16), 7301-7307. American Chemical Society
The Journal of Organic Chemistry

We report a visible light-induced trifluoromethylation and perfluoroalkylation for cysteine conjugation using Ru(bpy)3(2+) as photocatalyst and inexpensive RFI as coupling partner. The protocol allows the introduction of a variety of perfluoro alkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5eb12ab34e13562b25845ec878fcbbf
http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b01031

A Mechanistic Investigation of the Visible-Light Photocatalytic Trifluoromethylation of Heterocycles Using CF3 I in Flow

Autor: Minjing Shang, Timothy Noël, Niels J. König, Koen P. L. Kuijpers, Volker Hessel, Yuanhai Su

Publikováno v: Chemistry : A European Journal, 22(35), 12295-12300. Wiley-VCH Verlag

Photocatalytic radical trifluoromethylation strategies have impacted the synthesis of trifluoromethyl-containing molecules. However, mechanistic aspects concerning such transformations remain poorly understood. Here, we describe in detail the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f839733e6f00ef3ed9cdfe4de09e890c
https://pubmed.ncbi.nlm.nih.gov/27348274