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pro vyhledávání: '"Koen Kurt Smits"'
Autor:
R Galien, Raphael Geney, Koen Kurt Smits, Béatrice Vayssière, Thierry Christophe, Reginald Brys, L. Lepescheux, Ellen van der Aar, Luc Nelles, Fabrice Ciesielski, Guy Van Lommen, Pierre Deprez, Luc Juliaan Corina Van Rompaey, Muriel Uhring, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Philippe Clément-Lacroix, Javier Blanc, Nolwenn Jouannigot
Publikováno v:
Journal of Medicinal Chemistry. 57:9323-9342
Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small molecule has been shown to provide therapeutic immunomodulation. Having ident