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The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea

Autor: Grégoire Thomas, Thenral Socrates, Christian Mueller, Griet Vanpoucke, Wouter Laroy, Mihael Potocki, Tobias Breidthardt, Tamina Mosimann, Ronny Ziller, Alexandre Mebazaa, Beatrice Drexler, Koen Kas, Piet Moerman

Publikováno v: Clinical Science. 123:557-566

The risk stratification in patients presenting with acute dyspnoea remains a challenge. We therefore conducted a prospective, observational cohort study enrolling 292 patients presenting to the emergency department with acute dyspnoea. A proteomic ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee70a370cac9b05ec7257836baa47677
https://doi.org/10.1042/cs20120058

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Highly efficient peptide separations in proteomicsPart 2: Bi- and multidimensional liquid-based separation techniques

Autor: Katleen Verleysen, Robin Tuytten, Mahan Moshir, Koen Kas, Koen Sandra, Pat Sandra, Isabelle François, Filip D'hondt

Publikováno v: Journal of Chromatography B. 877:1019-1039

Multidimensional liquid-based separation techniques are described for maximizing the resolution of the enormous number of peptides generated upon tryptic digestion of proteomes, and hence, reduce the spatial and temporal complexity of the sample to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa398bbc138fb44d18424561cd8e3284
https://doi.org/10.1016/j.jchromb.2009.02.050

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Application of a Combined Weak Cation-Exchange/Crown Ether Column: First Demonstrations of a Versatile Tool for Proteome Subselection

Autor: Bart Ruttens, Katelijne Gheysen, Koen Sandra, José C. Martins, Pat Sandra, D. Vlieghe, Koen De Cremer, Robin Tuytten, Grégoire Thomas, Katleen Verleysen, Natalie Van Landuyt, Koen Kas

Publikováno v: Analytical Chemistry. 81:2456-2469

The present paper introduces the use of a weak cation-exchange/crown ether column in the proteomics field. The 18-crown-6 ether functionality is well-known to selectively complex ammonium and monoalkylammonium ions, which should make this column high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c833dc58cd7fc9d68bb4138b6f16a6a0
https://doi.org/10.1021/ac801975b

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A strategy for the prior processing of high-resolution mass spectral data obtained from high-dimensional combined fractional diagonal chromatography

Autor: Grégoire Thomas, Luc Krols, Dirk Valkenborg, Koen Kas, Tomasz Burzykowski

Publikováno v: Journal of Mass Spectrometry. 44:516-529

Combined fractional diagonal chromatography (COFRADIC) is a novel suite of gel-free technologies for the identification of biomarkers in complex peptide mixtures. For this purpose, reversed-phase high performance liquid chromatography (HPLC) technolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a9596491ffdb21f80e8c72cd82af1d
https://doi.org/10.1002/jms.1527

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Highly efficient peptide separations in proteomics

Autor: Koen Sandra, Pat Sandra, Filip D'hondt, Katleen Verleysen, Koen Kas, Mahan Moshir

Publikováno v: Journal of Chromatography B. 866:48-63

Sample complexity and dynamic range constitute enormous challenges in proteome analysis. The back-end technology in typical proteomics platforms, namely mass spectrometry (MS), can only tolerate a certain complexity, has a limited dynamic range per s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15c7472d736dfd9dc0337b7856c7db0c
https://doi.org/10.1016/j.jchromb.2007.10.034

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Combination of COFRADIC and high temperature – extended column length conventional liquid chromatography: A very efficient way to tackle complex protein samples, such as serum

Autor: Lies Vanneste, Pat Sandra, Kris Gevaert, Filip D'hondt, Koen Sandra, Koen Kas, Grégoire Thomas, Christine Labeur, Katleen Verleysen, Joël Vandekerckhove

Publikováno v: Journal of Separation Science. 30:658-668

The previously reported COmbined FRActional DIagonal Chromatography (COFRA-DIC) methodology, in which a subset of peptides representative for their parent proteins are sorted, is particularly powerful for whole proteome analysis. This peptide-centric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d34adfbb2f4f21da8ff8e9e2359edee
https://doi.org/10.1002/jssc.200600425

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Cloning and embryonic expression of zebrafish PLAG genes

Autor: Hélène Pendeville, Bernard Peers, Marianne Voz, Koen Kas

Publikováno v: Gene Expression Patterns. 6:267-276

PLAG transcription factors play important roles in oncogenesis. To date three members of this subfamily of zinc finger proteins have been identified in humans and mice: PLAG1, PLAGL1 and PLAGL2. In this study, we identified zebrafish orthologs of PLA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93eaafbbe0416b729d9ae8977bc57aa
https://doi.org/10.1016/j.modgep.2005.08.001

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Identification of a Karyopherin α2 Recognition Site in PLAG1, Which Functions As a Nuclear Localization Signal

Autor: Koen Kas, Wim J.M. Van de Ven, M.L. Voz, Caroline V. Braem, Maria Debiec-Rychter, E. Meyen

Publikováno v: Journal of Biological Chemistry. 277:19673-19678

The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of PLAG1 function, we searched for PLAG1-interactin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40f8be719fb5c4ee534aeb7dd988831
https://doi.org/10.1074/jbc.m112112200

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