Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Koen Jansen"'
Autor:
Trudy Straetemans, Guido J. J. Kierkels, Ruud Doorn, Koen Jansen, Sabine Heijhuurs, Joao M. dos Santos, Anna D. D. van Muyden, Henri Vie, Béatrice Clemenceau, Reinier Raymakers, Moniek de Witte, Zsolt Sebestyén, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-recep
Externí odkaz:
https://doaj.org/article/93a04137f7c647068f287b3c812a65cb
Autor:
Pieter Van der Veken, Gwendolyn Vliegen, Ruth Geiss-Friedlander, Ingrid De Meester, Koen Jansen, An De Decker, Anke Peeraer, Line Verckist, Dries Van Rompaey, Anne-Marie Lambeir, Koen Augustyns, Hans De Winter, An Bracke
Publikováno v:
ACS Med Chem Lett
ACS medicinal chemistry letters
ACS medicinal chemistry letters
[Image: see text] Fibroblast activation protein (FAP) is a proline-selective serine protease. It is hardly expressed in healthy adult tissue but upregulated in tissue remodeling sites associated with several diseases including epithelial cancer types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d228821345597060cdd871eb65c0c776
https://doi.org/10.1021/acsmedchemlett.9b00191
https://doi.org/10.1021/acsmedchemlett.9b00191
Autor:
Juraj Parajka, Lieke A. Melsen, Adriaan J. Teuling, Koen Jansen, Wouter J. M. Knoben, Marc Vis, Marco Dal Molin, James R. Craig
Publikováno v:
Water Resources Research, 57(5)
Water Resources Research 57 (2021) 5
Water Resources Research 57 (2021) 5
Models that mimic an original model might have a different model structure than the original model, that affects model output. This study assesses model structure differences and their impact on output by comparing 7 model implementations that carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0bd614be8bf29dec8dbb594bde41cc
https://doi.org/10.1029/2020wr029143
https://doi.org/10.1029/2020wr029143
Autor:
Oğuzhan Çopuroğlu, Ze Chang, Koen Jansen, Stefan Chaves Figueiredo, Erik Schlangen, Yu Chen, Zhenming Li
Publikováno v:
Cement and Concrete Research, 132
In 3D concrete printing (3DCP), it is necessary to meet contradicting rheological requirements: high fluidity during pumping and extrusion, and high stability and viscosity at rest to build the layered structure. In this paper, the impact of the hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5417fd8b245ba51416d5f60d8f75a871
http://resolver.tudelft.nl/uuid:ac5c1cb4-32be-4c93-9457-1cbab752c8da
http://resolver.tudelft.nl/uuid:ac5c1cb4-32be-4c93-9457-1cbab752c8da
Autor:
Ruud Doorn, Koen Jansen, Anna D.D. van Muyden, Zsolt Sebestyén, Trudy Straetemans, Moniek de Witte, Anke Janssen, Jürgen Kuball, Tineke Aarts, Marieke Simonis, Judith Bergboer
Publikováno v:
Mol Ther
Molecular Therapy, 28(2), 561. Nature Publishing Group
Molecular Therapy, 28(2), 561. Nature Publishing Group
Background & Aim Despite extensive usage of gene therapy medicinal products (GTMPs) in clinical studies and recent approval of CAR T cell therapy, little information has been made available on the precise molecular characterization and possible varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcae5077ef3f2e1537be5b93979bec9a
https://pubmed.ncbi.nlm.nih.gov/31882320
https://pubmed.ncbi.nlm.nih.gov/31882320
Autor:
Thomas M. van Gulik, Martien van Wenum, Sandrine Camus, Chung-Yin Tang, Ruurdtje Hoekstra, Koen Jansen, Philipp Treskes, Robert A. F. M. Chamuleau, Esmee J Coppens, Erik J. Hendriks
Publikováno v:
BIOFABRICATION, 9(3). IOP Publishing Ltd.
A new generation of bioartificial livers, based on differentiated proliferative hepatocyte sources, has been developed. Several practicable and regulatory demands have to be addressed before these can be clinically evaluated. We identified three main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d2bce519830ab4ecd18994231cf98e
https://doi.org/10.1088/1758-5090/aa7657
https://doi.org/10.1088/1758-5090/aa7657
Autor:
Koen Jansen, Koen Augustyns, Jurgen Joossens, Anne-Marie Lambeir, Jonathan D. Cheng, Robert Verkerk, Ingrid De Meester, Paul Cos, Pieter Van der Veken, Louis Maes, Leen Heirbaut
Publikováno v:
Journal of medicinal chemistry
Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV). It has been convincingly linked to multiple disease states involving remodeling of the extracellular matrix. FAP inhibition is investigated as a ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ff786f4a7d336a61c3616d6f24051b
https://doi.org/10.1021/jm500031w
https://doi.org/10.1021/jm500031w
Autor:
Jonathan D. Cheng, Koen Jansen, Ingrid De Meester, Hans De Winter, Xin Chen, Sebastiaan Van Goethem, Pieter Van der Veken, Jurgen Joossens, Nicole Lamoen, Leen Heirbaut, Anne-Marie Lambeir, Koen Augustyns
Publikováno v:
MedChemComm
Selected pyrrolidines, 2-cyanopyrrolidines and heteroaromatic isoindoline analogues were evaluated as P1-residues in dipeptide-derived inhibitors of DPP8/9. Potency testing indicates that DPP8 or DPP9 specificity cannot be obtained with the selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ef34cdb343bfae36de41f98e74b237
https://hdl.handle.net/10067/1332150151162165141
https://hdl.handle.net/10067/1332150151162165141
Autor:
Trudy Straetemans, Zsolt Sebestyén, Koen Jansen, Jarno Drost, Jürgen Kuball, Jacco van Rheenen, Sabine Heijhuurs, Inez Johanna
Publikováno v:
Cancer Research. 78:LB-104
γδT cells mediate cancer immune surveillance by sensing metabolic changes of malignant cells via their γδT cell receptor (TCR). Activation of γδTCR is independent of MHC molecules, making them a valuable addition to current treatment strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334d8175131d0701e53b173ed9c2d3b9
https://doi.org/10.1158/1538-7445.am2018-lb-104
https://doi.org/10.1158/1538-7445.am2018-lb-104