Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Koen H M Prange"'
Autor:
Lisa Willemsen, Annette E Neele, Saskia van der Velden, Koen H M Prange, Myrthe den Toom, Cindy P A A van Roomen, Myrthe E Reiche, Guillermo R Griffith, Marion J J Gijbels, Esther Lutgens, Menno P J de Winther
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 7, Iss 1 (2019)
Introduction Obesity is recognized as a risk factor for various microbial infections. The immune system, which is affected by obesity, plays an important role in the pathophysiology of these infections and other obesity-related comorbidities. Weight
Externí odkaz:
https://doaj.org/article/42a8071b1f924035ab50a83a567d6da6
Autor:
Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived
Externí odkaz:
https://doaj.org/article/77cc9364f8ea48a78af4b15a8220d6c9
Autor:
Jeroen Baardman, Sanne G. S. Verberk, Saskia van der Velden, Marion J. J. Gijbels, Cindy P. P. A. van Roomen, Judith C. Sluimer, Jelle Y. Broos, Guillermo R. Griffith, Koen H. M. Prange, Michel van Weeghel, Soufyan Lakbir, Douwe Molenaar, Elisa Meinster, Annette E. Neele, Gijs Kooij, Helga E. de Vries, Esther Lutgens, Kathryn E. Wellen, Menno P. J. de Winther, Jan Van den Bossche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages res
Externí odkaz:
https://doaj.org/article/2c0a011d044046398f11e576a0b58fa9
Autor:
Marie A. C. Depuydt, Frank H. Schaftenaar, Koen H. M. Prange, Arjan Boltjes, Esmeralda Hemme, Lucie Delfos, Jill de Mol, Maaike J. M. de Jong, Mireia N. A. Bernabé Kleijn, Judith A. H. M. Peeters, Lauren Goncalves, Anouk Wezel, Harm J. Smeets, Gert J. de Borst, Amanda C. Foks, Gerard Pasterkamp, Menno P. J. de Winther, Johan Kuiper, Ilze Bot, Bram Slütter
Publikováno v:
Nature Cardiovascular Research, 2, 112-125
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89880852bff6f6915225cfb1f3404505
https://doi.org/10.1038/s44161-022-00208-4
https://doi.org/10.1038/s44161-022-00208-4
Autor:
Michal Mokry, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M. Mekke, Marie A. C. Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C. Verwer, Adam W. Turner, Mohammad Daud Khan, Chani J. Hodonsky, Ernest Diez Benavente, Robin J. G. Hartman, Noortje A. M. van den Dungen, Nico Lansu, Emilia Nagyova, Koen H. M. Prange, Jason C. Kovacic, Johan L. M. Björkegren, Eleftherios Pavlos, Evangelos Andreakos, Heribert Schunkert, Gary K. Owens, Claudia Monaco, Aloke V. Finn, Renu Virmani, Nicholas J. Leeper, Menno P. J. de Winther, Johan Kuiper, Gert J. de Borst, Erik S. G. Stroes, Mete Civelek, Dominique P. V. de Kleijn, Hester M. den Ruijter, Folkert W. Asselbergs, Sander W. van der Laan, Clint L. Miller, Gerard Pasterkamp
Publikováno v:
Nature Cardiovascular Research. 1:1140-1155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09551ed0637bbdee31bff3cbbb429559
https://doi.org/10.1038/s44161-022-00171-0
https://doi.org/10.1038/s44161-022-00171-0
Autor:
Robin J. G. Hartman, Ernest Diez Benavente, Lotte Slenders, Arjan Boltjes, Barend M. Mol, Gert J. de Borst, Dominique P. V. de Kleijn, Koen H. M. Prange, Menno P. J. de Winther, Johan Kuiper, Mete Civelek, Sander W. van der Laan, Steve Horvath, Charlotte Onland-Moret, Michal Mokry, Gerard Pasterkamp, Hester M. den Ruijter
Epigenetic age estimators (clocks) are known to be predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques can be used for predicting secondary events. Here we estimated an age adjusted m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e1032483f300ea6a1cdb2a5f8b88cf
https://doi.org/10.1101/2023.02.16.23286067
https://doi.org/10.1101/2023.02.16.23286067
Autor:
Ernest Diez Benavente, Santosh Karnewar, Michele Buono, Eloi Mili, Robin J. G. Hartman, Daniek Kapteijn, Lotte Slenders, Mark Daniels, Redouane Aherrahrou, Tobias Reinberger, Barend M. Mol, Gert J. de Borst, Dominique P. V. de Kleijn, Koen H. M. Prange, Marie A. C. Depuydt, Menno P. J. de Winther, Johan Kuiper, Johan L. M. Björkegren, Jeanette Erdmann, Mete Civelek, Michal Mokry, Gary K Owens, Gerard Pasterkamp, Hester M. den Ruijter
Publikováno v:
bioRxiv
Women presenting with coronary artery disease (CAD) more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29622358fab42ec85fee2daa6dbd73cc
https://doi.org/10.1101/2023.02.08.527690
https://doi.org/10.1101/2023.02.08.527690