Výsledky vyhledávání - "Koen Glazenburg"

Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression

Autor: J. M. A. Pol, Koen Glazenburg, B.P.H. Peeters, R.J.M. Moormann, A. L. J. Gielkens

Publikováno v: Journal of Virology, 69, 189-197
Journal of Virology 69 (1995)

To investigate how altered control of expression of the essential immediate-early (IE) gene of pseudorabies virus influences virus replication and virulence, we replaced the IE promoter with the tissue-specific promoters of the bovine cytokeratin IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42d0db734573e46ba4b1819174d0a8b
https://doi.org/10.1128/jvi.69.1.189-197.1995

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Linker insertion mutagenesis of herpesviruses: inactivation of single genes within the Us region of pseudorabies virus

Autor: A. Berns, N de Wind, A. L. J. Gielkens, Alice Zijderveld, Koen Glazenburg

Publikováno v: Journal of Virology. 64:4691-4696

We describe a technique for the systematic inactivation of nonessential genes within the genome of a herpesvirus without the requirement for phenotypic selection. This technique is based on the insertion of an oligonucleotide containing translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b008b0723336c2f96a3f9d25215ce94
https://doi.org/10.1128/jvi.64.10.4691-4696.1990

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Insulin-like growth factor binding protein-1-6 expression in activated microglia

Autor: Nadine Wilczak, Koen Glazenburg, Felix Geeraedts, Jacques De Keyser, Daniel Chesik

Publikováno v: Neuroreport. 15(6)

In the CNS insulin-like growth factor-1 (IGF-1) enhances survival of neurons, promotes myelin synthesis and acts as a mitogen for microglia. The effects of IGF-1 are regulated by a family of 6 IGF binding proteins (IGFBPs). We investigated mRNA expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a5c7b84ee2f4ba057a5926f84483fd
https://pubmed.ncbi.nlm.nih.gov/15076729

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Effects of replacing the promoter of the immediate early gene with the promoter of Drosophila heat-shock gene HSP70 on the growth and virulence of pseudorabies virus

Autor: Arno L.J. Gielkens, Rob J. M. Moormann, Koen Glazenburg

Publikováno v: Veterinary microbiology. 33(1-4)

We investigated whether altering control of expression of an essential gene of pseudorabies virus (PRV) influences virus replication and virulence. The PRV immediate early (IE) gene was selected as a target, and its promoter was replaced with the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c9eb6645332a58419288dcbdee7e3
https://pubmed.ncbi.nlm.nih.gov/1336246

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