Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Koen Dockx"'
Autor:
Dorien De Pooter, Ben De Clerck, Koen Dockx, Domenica De Santis, Sarah Sauviller, Pascale Dehertogh, Matthias Beyens, Isabelle Bergiers, Isabel Nájera, Ellen Van Gulck, Nádia Conceição-Neto, Wim Pierson
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0304063 (2024)
Research on liver-related conditions requires a robust and efficient method to purify viable hepatocytes, lymphocytes and all other liver resident cells, such as Kupffer or liver sinusoidal endothelial cells. Here we describe a novel purification met
Externí odkaz:
https://doaj.org/article/b80be72f13f54bdfaa0add119102f4db
Autor:
Dorien De Pooter, Wim Pierson, Soheil Pourshahian, Koen Dockx, Ben De Clerck, Isabel Najera, Heather Davis, Ellen Van Gulck, Daniel Boden
Publikováno v:
Vaccines, Vol 12, Iss 3, p 237 (2024)
Chronic infection with hepatitis B virus (HBV) develops in millions of patients per year, despite the availability of effective prophylactic vaccines. Patients who resolve acute HBV infection develop HBV-specific polyfunctional T cells accompanied by
Externí odkaz:
https://doaj.org/article/df00572e29d84e5eb22d4366e69e6a16
Autor:
Nádia Conceição-Neto, Wim Pierson, Maurizio Vacca, Matthias Beyens, Ben De Clerck, Liese Aerts, Birgit Voeten, Dorien De Pooter, Lore Verschueren, Koen Dockx, Mathias Vandenberk, Ewoud De Troyer, Kato Verwilt, Carl Van Hove, Mieke Verslegers, Leslie Bosseler, Marjolein Crabbe, Vinod Krishna, Isabel Nájera, Ellen Van Gulck
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1825 (2023)
Background: Suppression of HBV DNA, inhibition of HBV surface (HBsAg) production and therapeutic vaccination to reverse HBV-specific T-cell exhaustion in chronic HBV patients are likely required to achieve a functional cure. In the AAV-HBV mouse mode
Externí odkaz:
https://doaj.org/article/02d6e9e3b591445ea06f0b781cc5a5c2
Autor:
Jeroen van Ameijde, Rosa Crespo, Roosmarijn Janson, Jarek Juraszek, Berdien Siregar, Hanneke Verveen, Imke Sprengers, Tariq Nahar, Jeroen J. Hoozemans, Stefan Steinbacher, Roland Willems, Lore Delbroek, Marianne Borgers, Koen Dockx, Kristof Van Kolen, Marc Mercken, Gabriel Pascual, Wouter Koudstaal, Adrian Apetri
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have
Externí odkaz:
https://doaj.org/article/953e8ff91c8e4f18bdde6ccba2569d9c
Autor:
Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs, Margot van Winsen, Martin H. Koldijk, David Zuijdgeest, Marianne Borgers, Koen Dockx, Esther J. M. Stoop, Wenli Yu, Els C. Brinkman-van der Linden, Kimberley Ummenthum, Kristof van Kolen, Marc Mercken, Stefan Steinbacher, Donata de Marco, Jeroen J. Hoozemans, Ian A. Wilson, Wouter Koudstaal, Jaap Goudsmit
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somaticall
Externí odkaz:
https://doaj.org/article/c0395ac19eb24ba4951a4cf53142723b
Autor:
Ellen Van Gulck, Marion Pardons, Erik Nijs, Nick Verheyen, Koen Dockx, Christel Van den Eynde, Emilie Battivelli, Jerel Vega, Eric Florence, Brigitte Autran, Nancie M. Archin, David M. Margolis, Kristine Katlama, Chiraz Hamimi, Ilse Van den Wyngaert, Filmon Eyassu, Linos Vandekerckhove, Daniel Boden
A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious virus once prolonged sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e27f9bd942c8cab7e5f7e17773de3c
https://doi.org/10.1101/2023.03.02.530914
https://doi.org/10.1101/2023.03.02.530914
Autor:
Marianne Borgers, Jeroen J.M. Hoozemans, Roosmarijn Janson, Jarek Juraszek, Lore Delbroek, Berdien Siregar, Marc Mercken, Imke Sprengers, Adrian Apetri, Jeroen van Ameijde, Roland Willems, Kristof Van Kolen, Wouter Koudstaal, Koen Dockx, Gabriel Pascual, Tariq Nahar, Hanneke Verveen, Stefan Steinbacher, Rosa Crespo
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Acta Neuropathologica Communinications, 6(1):59. BioMed Central
Acta Neuropathologica Communications
van Ameijde, J, Crespo, R, Janson, R, Juraszek, J, Siregar, B, Verveen, H, Sprengers, I, Nahar, T, Hoozemans, J J, Steinbacher, S, Willems, R, Delbroek, L, Borgers, M, Dockx, K, van Kolen, K, Mercken, M, Pascual, G, Koudstaal, W & Apetri, A 2018, ' Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser 422 containing epitope on pathological tau ', Acta Neuropathologica Communinications, vol. 6, no. 1, 59 . https://doi.org/10.1186/s40478-018-0562-9, https://doi.org/10.1186/s40478-018-0562-9
Acta Neuropathologica Communinications, 6(1):59. BioMed Central
Acta Neuropathologica Communications
van Ameijde, J, Crespo, R, Janson, R, Juraszek, J, Siregar, B, Verveen, H, Sprengers, I, Nahar, T, Hoozemans, J J, Steinbacher, S, Willems, R, Delbroek, L, Borgers, M, Dockx, K, van Kolen, K, Mercken, M, Pascual, G, Koudstaal, W & Apetri, A 2018, ' Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser 422 containing epitope on pathological tau ', Acta Neuropathologica Communinications, vol. 6, no. 1, 59 . https://doi.org/10.1186/s40478-018-0562-9, https://doi.org/10.1186/s40478-018-0562-9
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previous
Autor:
Jeroen van Ameijde, Trevin Holland, Hanna Inganäs, Ian A. Wilson, Gabriel Pascual, Hanneke Verveen, Roosmarijn Janson, Donata de Marco, Jeroen J.M. Hoozemans, Esther J. M. Stoop, Stefan Steinbacher, Renske Taggenbrock, Berdien Siregar, Rosa Crespo, Jay Wadia, Wouter Koudstaal, Margot van Winsen, Koen Dockx, Adrian Constantin Apetri, Jaap Goudsmit, Wenli Yu, David Zuijdgeest, Marianne Borgers, Jarek Juraszek, Heng Zhang, Elissa Keogh, Kristof Van Kolen, Kimberley Ummenthum, Martin H. Koldijk, Marc Mercken, Xueyong Zhu, Els C. M. Brinkman-Van der Linden, Michael Mrosek
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Apetri, A, Crespo, R, Juraszek, J, Pascual, G, Janson, R, Zhu, X, Zhang, H, Keogh, E, Holland, T, Wadia, J, Verveen, H, Siregar, B, Mrosek, M, Taggenbrock, R, Ameijde, J, Inganäs, H, van Winsen, M, Koldijk, M H, Zuijdgeest, D, Borgers, M, Dockx, K, Stoop, E J M, Yu, W, Brinkman-van der Linden, E C, Ummenthum, K, van Kolen, K, Mercken, M, Steinbacher, S, de Marco, D, Hoozemans, J J, Wilson, I A, Koudstaal, W & Goudsmit, J 2018, ' A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities ', Acta Neuropathologica Communinications, vol. 6, no. 1, 43, pp. 43 . https://doi.org/10.1186/s40478-018-0543-z, https://doi.org/10.1186/s40478-018-0543-z
Acta Neuropathologica Communinications, 6(1):43. BioMed Central
Apetri, A, Crespo, R, Juraszek, J, Pascual, G, Janson, R, Zhu, X, Zhang, H, Keogh, E, Holland, T, Wadia, J, Verveen, H, Siregar, B, Mrosek, M, Taggenbrock, R, Ameijde, J, Inganäs, H, van Winsen, M, Koldijk, M H, Zuijdgeest, D, Borgers, M, Dockx, K, Stoop, E J M, Yu, W, Brinkman-van der Linden, E C, Ummenthum, K, van Kolen, K, Mercken, M, Steinbacher, S, de Marco, D, Hoozemans, J J, Wilson, I A, Koudstaal, W & Goudsmit, J 2018, ' A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities ', Acta Neuropathologica Communinications, vol. 6, no. 1, 43, pp. 43 . https://doi.org/10.1186/s40478-018-0543-z, https://doi.org/10.1186/s40478-018-0543-z
Acta Neuropathologica Communinications, 6(1):43. BioMed Central
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG + memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated
Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Autor:
Margot van Winsen, Hanneke Verveen, Heng Zhang, Jarek Juraszek, Renske Taggenbrock, Els C. M. Brinkman-Van der Linden, Elissa Keogh, Gabriel Pascual, Stefan Steinbacher, Berdien Siregar, Jaap Goudsmit, Wenli Yu, Michael Mrosek, Adrian Constantin Apetri, Jeroen van Ameijde, Marianne Borgers, Martin H. Koldijk, Wouter Koudstaal, Jay Wadia, Trevin Holland, Kristof Van Kolen, Xueyong Zhu, Donata de Marco, Kimberley Ummenthum, Esther J. M. Stoop, Hanna Inganäs, Koen Dockx, Marc Mercken, Jeroen J.M. Hoozemans, Rosa Crespo, Roosmarijn Janson, Ian A. Wilson, David Zuijdgeest
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f55d99202634ace50c06b8d45d8562
Autor:
Rupesh Nanjunda, Andre Marreiro, Astrid Bottelbergs, Tom Van De Casteele, Luc Ver Donck, Roland Willems, Marc Vandermeeren, John A. Kemp, Cindy Wintmolders, Kristof Van Kolen, Peter Paul De Deyn, Thomas J. Malia, Lore Delbroek, Cristiano Sousa, Debby Van Dam, Clara Theunis, Guy Daneels, Bruno Vasconcelos, Koen Dockx, M. Borgers, Marc Mercken, Eilyn R. Lacy
Publikováno v:
Journal of alzheimers disease, 65(1), 265-281. IOS Press
Journal of Alzheimer's disease
Journal of Alzheimer's disease
The tau spreading hypothesis provides rationale for passive immunization with an anti-tau monoclonal antibody to block seeding by extracellular tau aggregates as a disease-modifying strategy for the treatment of Alzheimer's disease (AD) and potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1317f66f775c6f76fa8530c7ca6d40b
https://research.rug.nl/en/publications/8e06689d-d8de-4ef6-a82c-eabafd8b0c89
https://research.rug.nl/en/publications/8e06689d-d8de-4ef6-a82c-eabafd8b0c89