Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Koen D. W. Hendriks"'
1
Akademický článek
The Effects of 6-Chromanol SUL-138 during Hypothermic Machine Perfusion on Porcine Deceased Donor Kidneys
Autor: L. Annick van Furth, Leonie H. Venema, Koen D. W. Hendriks, Pieter C. Vogelaar, Guido Krenning, Henri G. D. Leuvenink
Publikováno v: Transplantology, Vol 2, Iss 3, Pp 304-314 (2021)
Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for kidney transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting tar
Externí odkaz: https://doaj.org/article/04ce744c5cb0468bb334fb3ca7c79ec0
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2
Akademický článek
Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion
Autor: Marziyeh Tolouee, Koen D. W. Hendriks, Fia Fia Lie, Lucas P. Gartzke, Maaike Goris, Femke Hoogstra-Berends, Steven Bergink, Robert H. Henning
Publikováno v: Cell Transplantation, Vol 31 (2022)
Cooling at 4°C is routinely used to lower metabolism and preserve cell and tissue integrity in laboratory and clinical settings, including organ transplantation. However, cooling and rewarming produce cell damage, attributed primarily to a burst of
Externí odkaz: https://doaj.org/article/c756303882ec4058bd4fb4dc35d03866
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3
Akademický článek
Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation
Autor: Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning, Henri G. D. Leuvenink
Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function remains unclear. Methods
Externí odkaz: https://doaj.org/article/e772a71da13c40ab8cae6bfb04fae314
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4
The Effects of 6-Chromanol SUL-138 during Hypothermic Machine Perfusion on Porcine Deceased Donor Kidneys
Autor: Koen D. W. Hendriks, Guido Krenning, Henri G. D. Leuvenink, P. Vogelaar, Leonie H Venema, L. Annick van Furth
Publikováno v: Transplantology
Volume 2
Issue 3
Pages 31-314
Transplantology, 2(3), 304-314. MDPI AG
Transplantology, Vol 2, Iss 31, Pp 304-314 (2021)
Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for kidney transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51697f740e92db24b6494a217816703c
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5
Hibernating mitochondria, the cool key to cellular protection and transplant optimization: Mitochondrial aspects of hibernators and non-hibernators in hypothermia
Autor: Koen D. W. Hendriks
Organ transplantation is a lifesaving therapy for patients suffering from end-stage organ failure. However, during the process of transplantation, organs are exposed to prolonged ischemia and subsequent reperfusion injury (I/R), which is detrimental
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5079928e3e661e3096abb09cbc4b4cd
https://research.rug.nl/en/publications/a2682187-076c-4997-8bba-6fb3234d5222
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6
Hibernator-Derived Cells Show Superior Protection and Survival in Hypothermia Compared to Non-Hibernator Cells
Autor: Koen D. W. Hendriks, Robert H. Henning, Janette Heegsma, Femke Hoogstra-Berends, Klaas Nico Faber, Christian P Joschko
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, 21(5):1864. MDPI AG
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1864 (2020)
Mitochondrial failure is recognized to play an important role in a variety of diseases. We previously showed hibernating species to have cell-autonomous protective mechanisms to resist cellular stress and sustain mitochondrial function. Here, we set
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3c7a3a7905b891700a9b9147724956
https://research.rug.nl/en/publications/154ce074-68de-4b42-840c-b11a31a36c65
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7
Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation
Autor: Robert H. Henning, Barbara M. Bakker, Robert J. Porte, Albert Gerding, Hanno Maassen, Koen D. W. Hendriks, Henri G. D. Leuvenink, Isabel M A Brüggenwirth
Publikováno v: Journal of translational medicine, 17(1):265. BioMed Central Ltd.
Journal of Translational Medicine
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function remains unclear. Methods We evalu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e807ee72d5135ba31740797e3dbed03
https://doi.org/10.1186/s12967-019-2013-1
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8
Gasotransmitters in health and disease: a mitochondria-centered view
Autor: Robert H. Henning, Peter R van Dijk, Koen D. W. Hendriks, Harry van Goor, Jan-Luuk Hillebrands, Hanno Maassen
Publikováno v: Current Opinion in Pharmacology, 45, 87-93. ELSEVIER SCI LTD
Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c62f4375f18fbaad106744adfb9cad
https://research.rug.nl/en/publications/0b8714c1-b8c4-4705-83cb-78c0ad4acd6d
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9
Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
Autor: Leonie H Venema, Koen D. W. Hendriks, Sijbrand Hofker, Harry van Goor, Hanno Maassen, Henri G. D. Leuvenink, Robert H. Henning, Annemieke M Coester
Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225152 (2019)
PLoS ONE, 14(11):0225152. PUBLIC LIBRARY SCIENCE
PLoS ONE
BackgroundSince the start of organ transplantation, hypothermia-forced hypometabolism has been the cornerstone in organ preservation. Cold preservation showed to protect against ischemia, although post-transplant injury still occurs and further impro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93533b8f1885ac82d4f5bc757748160d
https://doaj.org/article/8863d7161b8f4c5d83fc783e62e01f8e
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