Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Koen C. Oost"'
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100126- (2020)
Summary: Patient-derived organoids maintain functional and phenotypic characteristics of the original tissue such as cell-type diversity. Here, we provide protocols on how to label intestinal (cancer) stem cells by integrating the stem cell ASCL2 rep
Externí odkaz:
https://doaj.org/article/7cfad3f580b34877a7de744413024fcc
Autor:
Koen C. Oost, Lisa van Voorthuijsen, Arianna Fumagalli, Rik G.H. Lindeboom, Joep Sprangers, Manja Omerzu, Maria J. Rodriguez-Colman, Maria C. Heinz, Ingrid Verlaan-Klink, Madelon M. Maurice, Boudewijn M.T. Burgering, Jacco van Rheenen, Michiel Vermeulen, Hugo J.G. Snippert
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1600-1614 (2018)
Summary: Organoid technology provides the possibility of culturing patient-derived colon tissue and colorectal cancers (CRCs) while maintaining all functional and phenotypic characteristics. Labeling stem cells, especially in normal and benign tumor
Externí odkaz:
https://doaj.org/article/9ca3720b339f42e798b532a67bfc4e49
Autor:
Rik GH Lindeboom, Lisa van Voorthuijsen, Koen C Oost, Maria J Rodríguez‐Colman, Maria V Luna‐Velez, Cristina Furlan, Floriane Baraille, Pascal WTC Jansen, Agnès Ribeiro, Boudewijn MT Burgering, Hugo J Snippert, Michiel Vermeulen
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 6, Pp 1-16 (2018)
Abstract Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby representing a powerful in vitro system to investigate lineage specification and cellular differentiation. Here, we applied a multi‐omics framework on ste
Externí odkaz:
https://doaj.org/article/8a98095e739748a999d0a70f9fe23845
Autor:
Maria Azkanaz, Bernat Corominas-Murtra, Saskia I. J. Ellenbroek, Lotte Bruens, Anna T. Webb, Dimitrios Laskaris, Koen C. Oost, Simona J. A. Lafirenze, Karl Annusver, Hendrik A. Messal, Sharif Iqbal, Dustin J. Flanagan, David J. Huels, Felipe Rojas-Rodríguez, Miguel Vizoso, Maria Kasper, Owen J. Sansom, Hugo J. Snippert, Prisca Liberali, Benjamin D. Simons, Pekka Katajisto, Edouard Hannezo, Jacco van Rheenen
Publikováno v:
Nature, 607(7919), 548-554. Nature Publishing Group
Nature
Nature
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts(1-3). Whether stem cell numbers and behaviour vary at different sites is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056f78ddf82a288546d7d0c38e5f8447
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
Autor:
Hugo J.G. Snippert, Onno Kranenburg, Michiel Vermeulen, Jacco van Rheenen, Martijn Gloerich, Prisca Liberali, Inne H.M. Borel Rinkes, Ingrid Verlaan-Klink, Joris H. Hageman, Gustavo de Medeiros, Mirjam C. van der Net, Arianna Fumagalli, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Koen C. Oost, Niek A. Peters, Maria C. Heinz
Supplementary Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c4c4232fb540192e9921ef70f78607
https://doi.org/10.1158/0008-5472.22431123
https://doi.org/10.1158/0008-5472.22431123
Autor:
Hugo J.G. Snippert, Onno Kranenburg, Michiel Vermeulen, Jacco van Rheenen, Martijn Gloerich, Prisca Liberali, Inne H.M. Borel Rinkes, Ingrid Verlaan-Klink, Joris H. Hageman, Gustavo de Medeiros, Mirjam C. van der Net, Arianna Fumagalli, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Koen C. Oost, Niek A. Peters, Maria C. Heinz
Micrometastases of colorectal cancer can remain dormant for years prior to the formation of actively growing, clinically detectable lesions (i.e., colonization). A better understanding of this step in the metastatic cascade could help improve metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49935a71331f7c12f1dfc920e1314641
https://doi.org/10.1158/0008-5472.c.6513804
https://doi.org/10.1158/0008-5472.c.6513804
Autor:
Sippe G. de Vries, Wigard P. Kloosterman, Holger Rehmann, William Cross, Myrna van den Bos, Sander Boymans, Bingxin Lu, Susanne M.A. Lens, Hugo J. Snippert, Yannik Bollen, Markus J. van Roosmalen, Maximilian Mossner, Nicolle Besselink, Ellen Stelloo, Christopher Kimberley, Edwin Cuppen, Chris P. Barnes, Petra van Leenen, Bas Ponsioen, Ana C. F. Bolhaqueiro, Koen C. Oost, Bastiaan van der Roest, Trevor A. Graham, Andrea Sottoriva, Geert J. P. L. Kops, Leon W.M.M. Terstappen
Publikováno v:
Nature Genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651f73d2429a0f3686a912f64c06f306
https://doi.org/10.1038/s41588-021-00891-2
https://doi.org/10.1038/s41588-021-00891-2
Autor:
Hassan Melhem, Berna Kaya, Tanay Kaymak, Philipp Wuggenig, Emilio Flint, Julien Roux, Koen C. Oost, Claudia Cavelti-Weder, Maria L. Balmer, Jean-Claude Walser, Rodrigo A. Morales, Christian U. Riedel, Prisca Liberali, Eduardo J. Villablanca, Jan Hendrik Niess
Publikováno v:
Melhem, Hassan; Kaya, Berna; Kaymak, Tanay; Wuggenig, Philipp; Flint, Emilio; Roux, Julien; Oost, Koen C; Cavelti-Weder, Claudia; Balmer, Maria L; Walser, Jean-Claude; Morales, Rodrigo A; Riedel, Christian U; Liberali, Prisca; Villablanca, Eduardo J; Niess, Jan Hendrik (2022). Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal immunology, 15(3), pp. 443-458. Nature Publishing Group 10.1038/s41385-022-00494-y
Mucosal Immunology, 15 (3)
Mucosal Immunology, 15 (3)
Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health. However, the molecular pathways that regulate goblet cell function remain largely unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9e8f52ef3782192ac127f4651a9b30
https://boris.unibe.ch/167221/1/s41385-022-00494-y.pdf
https://boris.unibe.ch/167221/1/s41385-022-00494-y.pdf
Autor:
Maria C. Heinz, Niek A. Peters, Koen C. Oost, Rik G.H. Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C. van der Net, Gustavo de Medeiros, Joris H. Hageman, Ingrid Verlaan-Klink, Inne H.M. Borel Rinkes, Prisca Liberali, Martijn Gloerich, Jacco van Rheenen, Michiel Vermeulen, Onno Kranenburg, Hugo J.G. Snippert
Publikováno v:
Cancer Research, 82, 1953-1968
Cancer Research, 82, 10, pp. 1953-1968
Cancer Research, 82, 10, pp. 1953-1968
Micrometastases of colorectal cancer can remain dormant for years prior to the formation of actively growing, clinically detectable lesions (i.e., colonization). A better understanding of this step in the metastatic cascade could help improve metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee094c01da174dcd6d0aa74af53634
http://hdl.handle.net/2066/250973
http://hdl.handle.net/2066/250973
Autor:
Huili Hu, Ellen J. Wehrens, Koen C. Oost, Anne C. Rios, Annelotte M. Vonk, Jane E. Visvader, Hans Clevers, Johanna F. Dekkers, Paul R. Jamieson, Hendrikus C R Ariese, Maria Alieva, Jeffrey M. Beekman, Hugo J. Snippert, Gimano D. Amatngalim, Lianne M Wellens
Publikováno v:
Nature Protocols, 14(6), 1756-1771. Nature Publishing Group
In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the characterization of the cellular composition of organoids and demonstrated organoids' phenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167f6e747cde0439071404446ac4798
https://doi.org/10.1038/s41596-019-0160-8
https://doi.org/10.1038/s41596-019-0160-8