Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Koen Bruynseels"'
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Personalized medicine uses fine grained information on individual persons, to pinpoint deviations from the normal. ‘Digital Twins’ in engineering provide a conceptual framework to analyze these emerging data-driven health care practices, as well
Externí odkaz:
https://doaj.org/article/c8106e76af2445129d6ff6867bbb7dec
Autor:
Fred Van Leuven, Ina Tesseur, Francisca C. Bronfman, Jo Van Dorpe, Alfons Van Lommel, Koen Bruynseels, Raphael Sciot
Publikováno v:
The American Journal of Pathology. 157:1495-1510
The epsilon 4 allele of the human apolipoprotein E gene (ApoE4) constitutes an important genetic risk factor for Alzheimer’s disease. Recent experimental evidence suggests that human ApoE is expressed in neurons, in addition to being synthesized in
Autor:
Kris Vandezande, Ruth J. F. Loos, Chris Van den Haute, Hugo Geerts, Jo Van Dorpe, Koen Bruynseels, Kurt Spittaels, Isabelle Laenen, Alfons Van Lommel, Marc Mercken, Fred Van Leuven, Raf Sciot
Publikováno v:
The American Journal of Pathology. 155:2153-2165
Mutations in the human tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some mutations, including mutations in intron 10, induce increased levels of the functionally normal four-repeat tau protein isoform, leading to n
Autor:
D Ashton, J. Van Dorpe, M Irizarry, D. Terwel, Koen Bruynseels, F. Van Leuven, Kurt Spittaels, B. T. Hyman, Ruth J. F. Loos, Kris Vandezande, Hugo Geerts, Reena Lasrado, Jackie R. Vandenheede, Marleen Verhoye, M Mercken, C. Van den Haute, J Van Lint, A. Van der Linden
Publikováno v:
Neuroscience
Glycogen synthase kinase-3beta (GSK-3beta) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd14708483903824c5b604595ee95f25
https://hdl.handle.net/10067/459930151162165141
https://hdl.handle.net/10067/459930151162165141
Autor:
M Lambrechts, T Boon, Olivier S. Descamps, L Stas, Els Thiry, F. Van Leuven, Erik Muls, Koen Bruynseels
Publikováno v:
Atherosclerosis. 154(3)
Five coding polymorphisms in de LRP1 gene, i.e. A217V, A775P, D2080N, D2632E and G4379S were discovered by sequencing its 89 exons in three test-groups of 22 healthy individuals, 29 Alzheimer patients and 18 individuals with different clinical and mo
Autor:
Dieter Nuyens, Cuno Kuiperi, Isabelle Laenen, Ruth J. F. Loos, Chris Van den Haute, Fred Van Leuven, Liesbet Smeijers, Dieder Moechars, Ina Tesseur, Frédéric Checler, Ilse Dewachter, Marc Mercken, Jo Van Dorpe, Raf Sciot, Koen Bruynseels, Hugo Vanderstichele, Kurt Spittaels
Publikováno v:
Scopus-Elsevier
Deposition of amyloid beta-peptide (Abeta) in cerebral vessel walls (cerebral amyloid angiopathy, CAA) is very frequent in Alzheimer's disease and occurs also as a sporadic disorder. Here, we describe significant CAA in addition to amyloid plaques, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e60c5fae5123eee02ad72256f8c6f40
https://europepmc.org/articles/PMC1850171/
https://europepmc.org/articles/PMC1850171/
Autor:
Chris Van den Haute, Jo Van Dorpe, Johan Van Lint, Ruth J. F. Loos, Kris Vandezande, Diederik Moechars, Reena Lasrado, Fred Van Leuven, Tim Boon, Jackie R. Vandenheede, Marc Mercken, Kurt Spittaels, Hugo Geerts, Isabelle Laenen, Koen Bruynseels
Publikováno v:
The Journal of biological chemistry. 275(52)
Protein tau filaments in brain of patients suffering from Alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated. The responsible kinases operating in vivo in neurons still need to be id
Autor:
Koen Bruynseels, Johan Vos
Publikováno v:
Virtual Worlds ISBN: 9783540677079
Virtual Worlds
Virtual Worlds
Tacit knowledge is unstructured knowledge that is implicitly present in a community, but is not readily organized or available for its members. Virtual communities can be instrumental in the organization and presentation of such tacit knowledge. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f4df3b1a344ce24a45886e98fd5fb4
https://doi.org/10.1007/3-540-45016-5_3
https://doi.org/10.1007/3-540-45016-5_3
Autor:
Kurt Spittaels, Fred Van Leuven, Ina Tesseur, Chris Van den Haute, Koen Bruynseels, Jo Van Dorpe
Publikováno v:
Neurobiology of Aging. 21:60