Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Koen Beerens"'
Publikováno v:
Current Research in Biotechnology, Vol 4, Iss , Pp 350-358 (2022)
UDP-galactose 4-epimerase (Gal4E, EC 5.1.3.2) catalyses the interconversion of UDP-galactose and UDP-glucose by inverting the configuration of the 4′-hydroxyl group of the sugar moiety. This enzyme is one of the mechanistically best-characterized m
Externí odkaz:
https://doaj.org/article/7e9f19430da34db9939542e61a9a18d2
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1964-1989 (2020)
Although trehalose has recently gained interest because of its pharmaceutical potential, its clinical use is hampered due to its low bioavailability. Hence, hydrolysis-resistant trehalose analogues retaining biological activity could be of interest.
Externí odkaz:
https://doaj.org/article/1360e90331fe40d4b7a5126adc3c039a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
GDP-mannose 3,5-epimerase (GM35E, GME) belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily and catalyses the conversion of GDP-d-mannose towards GDP-l-galactose. Although the overall reaction seems relatively simple (a double
Externí odkaz:
https://doaj.org/article/3c6918e22b3846fd98d9d5851aef115f
Publikováno v:
Molecules, Vol 23, Iss 10, p 2519 (2018)
Cellobiose 2-epimerase from Rhodothermus marinus (RmCE) reversibly converts a glucose residue to a mannose residue at the reducing end of β-1,4-linked oligosaccharides. In this study, the monosaccharide specificity of RmCE has been mapped and the sy
Externí odkaz:
https://doaj.org/article/70f27437da544f83bb46d6fa1cf46b70
Autor:
David Bednar, Koen Beerens, Eva Sebestova, Jaroslav Bendl, Sagar Khare, Radka Chaloupkova, Zbynek Prokop, Jan Brezovsky, David Baker, Jiri Damborsky
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004556 (2015)
There is great interest in increasing proteins' stability to enhance their utility as biocatalysts, therapeutics, diagnostics and nanomaterials. Directed evolution is a powerful, but experimentally strenuous approach. Computational methods offer attr
Externí odkaz:
https://doaj.org/article/3d38101113604560ba9dd00952e39a1e
Autor:
Shari Dhaene, Amar Van Laar, Marc De Doncker, Emma De Beul, Koen Beerens, Charlotte Grootaert, Jurgen Caroen, Johan Van der Eycken, John Van Camp, Tom Desmet
Publikováno v:
Journal of Agricultural and Food Chemistry. 70:3502-3511
In view of the global pandemic of obesity and related metabolic diseases, there is an increased interest in alternative carbohydrates with promising physiochemical and health-related properties as a potential replacement for traditional sugars. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157c6ea815ccb59d5f501a1eb54447fe
https://doi.org/10.1021/acs.jafc.1c07709
https://doi.org/10.1021/acs.jafc.1c07709
Publikováno v:
FOOD CHEMISTRY
The impact of glycosidic linkage of seven rare and new-to-nature disaccharides on gut bacteria was assessed in vitro. The community shift of the inocula from four donors in response to 1 % (w/v) disaccharide supplemen-tation was captured by sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c11350cb6b64d34c895747f48baacc
https://doi.org/10.1016/j.foodchem.2023.135440
https://doi.org/10.1016/j.foodchem.2023.135440
Publikováno v:
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology
Abstract β-Glucan phosphorylases are carbohydrate-active enzymes that catalyze the reversible degradation of β-linked glucose polymers, with outstanding potential for the biocatalytic bottom-up synthesis of β-glucans as major bioactive compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789ab9d07197c9e6ff4778d183e4e24f
https://doi.org/10.1007/s00253-021-11320-z
https://doi.org/10.1007/s00253-021-11320-z
Autor:
Joris R. Delanghe, Jeroen Beeckman, Koen Beerens, Jonas Himpe, Nezahat Bostan, Marijn M. Speeckaert, Margo Notebaert, Manon Huizing, Elisabeth Van Aken
Publikováno v:
International journal of molecular sciences
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7343
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7343
Presbyopia is an age-related vision disorder that is a global public health problem. Up to 85% of people aged ≥40 years develop presbyopia. In 2015, 1.8 billion people globally had presbyopia. Of those with significant near vision disabilities due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60e665acad52c4c0836eda8ea9cf68d
https://doi.org/10.3390/ijms24087343
https://doi.org/10.3390/ijms24087343
Publikováno v:
International Journal of Biological Macromolecules. 165:1862-1868
GDP-mannose 3,5-epimerase (GM35E) catalyzes the double epimerization of GDP-mannose to yield GDP-l-galactose. GDP-l-gulose (C5-epimer) has previously been detected as a byproduct of this reaction, indicating that C3,5-epimerization occurs through an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d224fcf11ecef5fee2da394a6738209e
https://doi.org/10.1016/j.ijbiomac.2020.10.067
https://doi.org/10.1016/j.ijbiomac.2020.10.067