Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Koen A Stam"'
Autor:
Madeleine Eunice Betouke Ongwe, Yoanne D Mouwenda, Koen A Stam, Peter G Kremsner, Bertrand Lell, David Diemert, Jeff Bethony, Maria E Bottazzi, Peter J Hotez, Remko V Leeuwen, Martin P Grobusch, Ayola A Adegnika, Oleg A Mayboroda, Maria Yazdanbakhsh
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275013 (2022)
Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living eit
Externí odkaz:
https://doaj.org/article/ed445e508fab47d0a4352a9fcd870d4f
Autor:
Yoanne D Mouwenda, Madeleine E Betouke Ongwe, Friederike Sonnet, Koen A Stam, Lucja A Labuda, Sophie De Vries, Martin P Grobusch, Frejus J Zinsou, Yabo J Honkpehedji, Jean-Claude Dejon Agobe, David J Diemert, Remko van Leeuwen, Maria E Bottazzi, Peter J Hotez, Peter G Kremsner, Jeffrey M Bethony, Simon P Jochems, Ayola A Adegnika, Marguerite Massinga Loembe, Maria Yazdanbakhsh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009732 (2021)
Two hookworm vaccine candidates, Na-GST-1 and Na-APR-1, formulated with Glucopyranosyl Lipid A (GLA-AF) adjuvant, have been shown to be safe, well tolerated, and to induce antibody responses in a Phase 1 clinical trial (Clinicaltrials.gov NCT02126462
Externí odkaz:
https://doaj.org/article/74b241e8340f43ffaff17b49d024c36c
Publikováno v:
van Wieringen, W N, Stam, K A, Peeters, C F W & van de Wiel, M A 2020, ' Updating of the Gaussian graphical model through targeted penalized estimation ', Journal of Multivariate Analysis, vol. 178, 104621 . https://doi.org/10.1016/j.jmva.2020.104621
Journal of Multivariate Analysis, 178:104621. Academic Press Inc.
van Wieringen, W N, Stam, K A, Peeters, C F W & van de Wiel, M A 2020, ' Updating of the Gaussian graphical model through targeted penalized estimation ', Journal of Multivariate Analysis, vol. 178, 104621, pp. 1-14 . https://doi.org/10.1016/j.jmva.2020.104621
Journal of Multivariate Analysis, 178:104621, 1-14. Academic Press Inc.
Journal of Multivariate Analysis, 178:104621. Academic Press Inc.
van Wieringen, W N, Stam, K A, Peeters, C F W & van de Wiel, M A 2020, ' Updating of the Gaussian graphical model through targeted penalized estimation ', Journal of Multivariate Analysis, vol. 178, 104621, pp. 1-14 . https://doi.org/10.1016/j.jmva.2020.104621
Journal of Multivariate Analysis, 178:104621, 1-14. Academic Press Inc.
Updating of the Gaussian graphical model via shrinkage estimation is studied. This shrinkage is towards a nonzero parameter value representing prior quantitative information. Once new data become available, the previously estimated parameter needs up
Autor:
Frejus Jeannot Zinsou, David Diemert, Jeffrey M. Bethony, Simon P. Jochems, Martin P. Grobusch, Yabo Josiane Honkpehedji, Sophie De Vries, Maria Elena Bottazzi, Peter J. Hotez, Remko van Leeuwen, Peter G. Kremsner, Friederike Sonnet, Jean-Claude Dejon Agobe, Ayola A. Adegnika, Yoanne D. Mouwenda, Koen A. Stam, Lucja A. Labuda, Marguerite Massinga Loembe, Madeleine E. Betouke Ongwe, Maria Yazdanbakhsh
Publikováno v:
PLOS NEGLECTED TROPICAL DISEASES, 15(10). PUBLIC LIBRARY SCIENCE
PLoS neglected tropical diseases, 15(10):e0009732. Public Library of Science
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009732 (2021)
PLoS neglected tropical diseases, 15(10):e0009732. Public Library of Science
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009732 (2021)
Two hookworm vaccine candidates, Na-GST-1 and Na-APR-1, formulated with Glucopyranosyl Lipid A (GLA-AF) adjuvant, have been shown to be safe, well tolerated, and to induce antibody responses in a Phase 1 clinical trial (Clinicaltrials.gov NCT02126462
Autor:
Simon P. Jochems, Shohreh Azimi, Jelle J. Goeman, Marcel J. T. Reinders, Peter G. Kremsner, Sanne E. de Jong, Koen A. Stam, Meta Roestenberg, Frits Koning, B. Kim Lee Sim, Vincent van Unen, Mikhael D Manurung, Anna Vilanova, Benjamin Mordmüller, Elmar Eisemann, Rolf Fendel, Boudewijn P. F. Lelieveldt, Nicola Pezzotti, Maria Yazdanbakhsh, Yoanne D. Mouwenda, Yvonne C. M. Kruize, Stephen L. Hoffman, Madeleine Eunice Betouke Ongwe, Freia-Raphaella Lorenz, Marion H. König, Thomas Höllt, Bertrand Lell
Publikováno v:
Nature Immunology, 22, 5, pp. 654-665
Nature Immunology
Nature Immunology, 22(5)
Nature Immunology, 22, 654-665
Nature Immunology, 22(5), 654-665. NATURE RESEARCH
Nature Immunology
Nature Immunology, 22(5)
Nature Immunology, 22, 654-665
Nature Immunology, 22(5), 654-665. NATURE RESEARCH
Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab80d0879d5062e642566300a7b0d1e
https://repository.ubn.ru.nl/handle/2066/238471
https://repository.ubn.ru.nl/handle/2066/238471
Autor:
Petra H. Verbeek-Menken, Koen A. Stam, Angela van Diepen, Erliyani Sartono, Govert J. van Dam, Martha T. van der Beek, Beatrice M. F. Winkel, Cornelis H. Hokke, Pauline Meij, Simon P. Jochems, C. Feijt, Claudia J. de Dood, Jacqueline J. Janse, Roos van Schuijlenburg, Janneke Kos-van Oosterhoud, Paul L. A. M. Corstjens, Fijs W. B. van Leeuwen, Meta Roestenberg, Arifa Ozir-Fazalalikhan, Maria Yazdanbakhsh, Mikhael D Manurung, Marijke C. C. Langenberg, Lisette van Lieshout, Leo G. Visser, Marie-Astrid Hoogerwerf, Jan Pieter R. Koopman
Publikováno v:
Nature Medicine, 26(3), 326-332. NATURE PUBLISHING GROUP
Nature Medicine
Nature Medicine
Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is insufficient to control transmission in highly endemic areas1. Novel medicines and vaccines are urgently needed2,3. An experimental human model for schistosomiasis c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad117a8e027324925e79d044d764b5e
https://www.nature.com/articles/s41591-020-0759-x
https://www.nature.com/articles/s41591-020-0759-x
Autor:
Moustapha Mbow, Thomas Höllt, Koen A. Stam, Erliyani Sartono, Sandra Laban, Boudewijn P. F. Lelieveldt, Marion H. König, Taniawati Supali, Dicky L. Tahapary, Maria Yazdanbakhsh, Simon P. Jochems, Karin de Ruiter, Vincent van Unen, Johannes W. A. Smit, Frits Koning
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 12
Science Translational Medicine, 12, 524
Science Translational Medicine, 12(524)
Science Translational Medicine, 12
Science Translational Medicine, 12, 524
Science Translational Medicine, 12(524)
Helminth infections induce strong type 2 and regulatory responses, but the degree of heterogeneity of such cells is not well characterized. Using mass cytometry, we profiled these cells in Europeans and Indonesians not exposed to helminths and in Ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731bd338e41701f7a502d233cb79e138
https://hdl.handle.net/1887/86933
https://hdl.handle.net/1887/86933
Publikováno v:
Journal of Visualized Experiments. JOURNAL OF VISUALIZED EXPERIMENTS
ISSUE=154;TITLE=Journal of Visualized Experiments
ISSUE=154;TITLE=Journal of Visualized Experiments
The complexity of data generated by mass cytometry has necessitated new tools to rapidly visualize analytic outcomes. Clustering methods like Cytosplore or FlowSOM are used for the visualization and identification of cell clusters. For downstream ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478c184320acdce40e6511fe77c4f944
https://hdl.handle.net/1887/121508
https://hdl.handle.net/1887/121508
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss, Pp 435-442 (2018)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 16, 435-442
Computational and Structural Biotechnology Journal, 16
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 16, 435-442
Computational and Structural Biotechnology Journal, 16
Multi-parametric flow and mass cytometry allows exceptional high-resolution exploration of the cellular composition of the immune system. A large panel of computational tools have been developed to analyze the high-dimensional landscape of the data g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c1766f19e68ee40f9513174b25a1ca
https://doi.org/10.1016/j.csbj.2018.10.004
https://doi.org/10.1016/j.csbj.2018.10.004
Publikováno v:
Proceedings of the Royal Society B
Proceedings of the Royal Society B, 281(1796)
Proceedings of the Royal Society B, 281(1796)
Vocal acquisition in songbirds and humans shows many similarities, one of which is that both involve a combination of experience and perceptual predispositions. Among languages some speech sounds are shared, while others are not. This could reflect a