Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Koen, Augustyns"'
Autor:
Vincent de Laat, Halit Topal, Xander Spotbeen, Ali Talebi, Jonas Dehairs, Jakub Idkowiak, Frank Vanderhoydonc, Tessa Ostyn, Peihua Zhao, Maarten Jacquemyn, Michele Wölk, Anna Sablina, Koen Augustyns, Tom Vanden Berghe, Tania Roskams, Dirk Daelemans, Maria Fedorova, Baki Topal, Johannes V. Swinnen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors of patients with pancreatic ductal aden
Externí odkaz:
https://doaj.org/article/8f15dc65565c4b5099ae63fd1bafc0fa
Autor:
Karuna Adhikari, Maarten Vanermen, Gustavo Da Silva, Tim Van den Wyngaert, Koen Augustyns, Filipe Elvas
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-56 (2024)
Abstract Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels–Alder reactions. Since their discovery as bioorthogonal reaction partners, novel TCO deri
Externí odkaz:
https://doaj.org/article/2f2c94c1235e40a6b6b11ce4f6ed7def
Autor:
Natalia Smiejkowska, Lauren Oorts, Kevin Van Calster, Linda De Vooght, Rob Geens, Henri-Philippe Mattelaer, Koen Augustyns, Sergei V. Strelkov, Dirk Lamprecht, Koen Temmerman, Yann G.-J. Sterckx, Davie Cappoen, Paul Cos
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTThe World Health Organization’s goal to combat tuberculosis (TB) is hindered by the emergence of anti-microbial resistance, therefore necessitating the exploration of new drug targets. Multidrug regimens are indispensable in TB therapy as t
Externí odkaz:
https://doaj.org/article/c8fac40f6384460fafe887ecb260e268
Autor:
Karuna Adhikari, Jonatan Dewulf, Christel Vangestel, Pieter Van der Veken, Sigrid Stroobants, Filipe Elvas, Koen Augustyns
Publikováno v:
ACS Omega, Vol 8, Iss 41, Pp 38252-38262 (2023)
Externí odkaz:
https://doaj.org/article/eb3942f162174473a450163bce286f3a
Autor:
Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, Matthias Govaerts, Juliana Aizawa, Päivi Tammela, Raivis Žalubovskis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibac
Externí odkaz:
https://doaj.org/article/d7d196adf4464caaa61e8aa20fcbc597
Autor:
Murat Bozdag, Freke Mertens, An Matheeussen, Natascha Van Pelt, Kenn Foubert, Nina Hermans, Guido R. Y. De Meyer, Koen Augustyns, Wim Martinet, Guy Caljon, Pieter Van der Veken
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4693 (2024)
Herein, we report a series of 1,3-diarylpyrazoles that are analogues of compound 26/HIT 8. We previously identified this molecule as a ‘hit’ during a high-throughput screening campaign for autophagy inducers. A variety of synthetic strategies wer
Externí odkaz:
https://doaj.org/article/18dabefed2da4cbd90ffbaf508400672
Autor:
Camilla Scarpellini, Sophie Valembois, Kenneth Goossens, Mike Vadi, Caroline Lanthier, Greta Klejborowska, Pieter Van Der Veken, Hans De Winter, Mathieu J. M. Bertrand, Koen Augustyns
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Receptor-Interacting serine/threonine-Protein Kinase 1 (RIPK1) emerged as an important driver of inflammation and, consequently, inflammatory pathologies. The enzymatic activity of RIPK1 is known to indirectly promote inflammation by triggering cell
Externí odkaz:
https://doaj.org/article/0f93ee492f8849b39af739d171b0590b
Autor:
Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns, Tom Vanden Berghe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Catalytic iron is associated with intensive care unit mortality and is known to cause free radical-mediated cellular toxicity. Here the authors show that a soluble ferrostatin-analogue (a ferroptosis inhibitor) protects mice from injury and death in
Externí odkaz:
https://doaj.org/article/a4909380e98741e3bf0ff690fb71d483
Autor:
Alba Ramos-Llorca, Lisse Decraecker, Valérie M. Y. Cacheux, Irena Zeiburlina, Michelle De bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter Van Der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza, Koen Augustyns
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemica
Externí odkaz:
https://doaj.org/article/084ad8fa8c424c0d8ed10c4e2a49fa74
Autor:
Hannah Ceuleers, Nikita Hanning, Michelle De bruyn, Joris G De Man, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic a
Externí odkaz:
https://doaj.org/article/2e982d8ea77b4cd0af0421bfcbe928ff