Measuring H3 receptor occupancy of the experimental anti-Parkinsonian drug AG0029, using [11C]GSK-189254 and PET

Autor: Ghazanfari, Nafiseh, van Waarde, Aren, Sijbesma, Jurgen, Doorduin, Janine, Vállez García, David, Kominia, Maria, Koelewijn, Martin, Attia, Khaled, Visser, Ton J, Heeres, André, Willemsen, Antoon, de Vries, Erik F., Dierckx, Rudi, Elsinga, Philip H.

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 48(Suppl.1):OP-0278, S108-S109. SPRINGER

Aim/Introduction: Inadequacies of currently designed drugs in treating neurodegenerative disorders have promoted efforts to develop novel drugs interacting with multiple targets. As part of a collaborative drug discovery program, AG-0029 was develope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::78ae795c6e8aa1da2dbba597db042a5f
https://research.rug.nl/en/publications/b3dbbd6b-d9c2-40c0-9fd1-9500d05a7ca4

Binding of the experimental dual-action antiparkinsonian drug AG-0029 to dopamine D2 and histamine H3 receptors: a PET study in healthy rats

Autor: van Waarde, Aren, Ghazanfari, Nafiseh, Sijbesma, Jurgen, Vállez García, David, Kominia, Maria, Koelewijn, Martin, Attia, Khaled, Visser, Ton J, Heeres, André, Willemsen, Antoon, Dierckx, Rudi, Elsinga, Philip H.

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 47(Suppl.1). SPRINGER

Aim/Introduction: Drugs interacting with multiple targets are under study for the treatment of disorders of the central nervous system. AG-00291 combines very potent agonist affinity (0.08 nM) to the dopamine D2 receptor with moderate antagonist affi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1e6a63686f4e0c8b8a1b984e7487a51d
https://research.rug.nl/en/publications/9d3e99e5-9ec4-4db0-887a-32aaa83c223a

Binding of the Dual-Action Anti-Parkinsonian Drug AG-0029 to Dopamine D2and Histamine H3Receptors: A PET Study in Healthy Rats

Autor: Ghazanfari, Nafiseh, van Waarde, Aren, Doorduin, Janine, Sijbesma, Jürgen W. A., Kominia, Maria, Koelewijn, Martin, Attia, Khaled, Vállez-García, David, Willemsen, Antoon T. M., Heeres, André, Dierckx, Rudi A. J. O., Visser, Ton J., de Vries, Erik F. J., Elsinga, Philip H.

Publikováno v: Molecular Pharmaceutics; July 2022, Vol. 19 Issue: 7 p2287-2298, 12p

Pharmacokinetic Modeling of [ ¹¹ C]GSK-189254, PET Tracer Targeting H 3 Receptors, in Rat Brain.

Autor: Ghazanfari N; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., van Waarde A; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Doorduin J; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Sijbesma JWA; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Kominia M; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Koelewijn M; Symeres, Groningen 9747 AT, The Netherlands., Attia K; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Willemsen ATM; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Visser TJ; Symeres, Groningen 9747 AT, The Netherlands., Heeres A; Symeres, Groningen 9747 AT, The Netherlands., Dierckx RAJO; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., de Vries EFJ; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands., Elsinga PH; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen 9700 RB, The Netherlands.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2022 Mar 07; Vol. 19 (3), pp. 918-928. Date of Electronic Publication: 2022 Feb 16.