Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach.

Autor: Schott CR; Department of Pediatrics, University of California San Francisco, San Francisco, California.; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada., Koehne AL; Department of Pediatrics, University of California San Francisco, San Francisco, California., Sayles LC; Department of Pediatrics, University of California San Francisco, San Francisco, California., Young EP; Department of Pediatrics, University of California San Francisco, San Francisco, California., Luck C; Department of Pediatrics, University of California San Francisco, San Francisco, California.; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, California., Yu K; Department of Pediatrics, University of California San Francisco, San Francisco, California.; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, California., Lee AG; Department of Pediatrics, University of California San Francisco, San Francisco, California., Breese MR; Department of Pediatrics, University of California San Francisco, San Francisco, California., Leung SG; Department of Pediatrics, University of California San Francisco, San Francisco, California., Xu H; Departments of Genetics and Medicine, Stanford University School of Medicine, Stanford University, Stanford, California., Shah AT; Department of Pediatrics, University of California San Francisco, San Francisco, California., Liu HY; Department of Pediatrics, University of California San Francisco, San Francisco, California., Spillinger A; Department of Pediatrics, University of California San Francisco, San Francisco, California., Behroozfard IH; Department of Pediatrics, University of California San Francisco, San Francisco, California., Marini KD; Department of Pediatrics, University of California San Francisco, San Francisco, California., Dinh PT; Department of Pediatrics, University of California San Francisco, San Francisco, California., Pons Ventura MV; Department of Pediatrics, University of California San Francisco, San Francisco, California., Vanderboon EN; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada., Hazard FK; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California., Cho SJ; Department of Pathology, University of California San Francisco, San Francisco, California., Avedian RS; Department of Orthopedic Surgery, Stanford University School of Medicine, Stanford University, Stanford, California., Mohler DG; Department of Orthopedic Surgery, Stanford University School of Medicine, Stanford University, Stanford, California., Zimel M; Department of Orthopedic Surgery, University of California San Francisco, San Francisco, California., Wustrack R; Department of Orthopedic Surgery, University of California San Francisco, San Francisco, California., Curtis C; Departments of Genetics and Medicine, Stanford University School of Medicine, Stanford University, Stanford, California., Sirota M; Department of Pediatrics, University of California San Francisco, San Francisco, California.; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, California., Sweet-Cordero EA; Department of Pediatrics, University of California San Francisco, San Francisco, California.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Feb 16; Vol. 30 (4), pp. 849-864.

T cell-inflamed gene expression profile is associated with favorable disease-specific survival in non-hypermutated microsatellite-stable colorectal cancer patients.

Autor: Yin H; Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA., Harrison TA; Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Thomas SS; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Sather CL; Genomics Resource, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Koehne AL; Experimental Histopathology, Shared Resource, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Malen RC; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Reedy AM; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Wurscher MA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Zaidi SHE; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Publikováno v: Cancer medicine [Cancer Med] 2023 Mar; Vol. 12 (6), pp. 6583-6593. Date of Electronic Publication: 2022 Nov 07.

Anticoagulation targeting membrane-bound anionic phospholipids improves outcomes of traumatic brain injury in mice.

Autor: Dong X; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.; Bloodworks Research Institute, Seattle, WA., Liu W; Institute of Pathology, School of Medical Sciences and Gansu Provincial Key Laboratory of Preclinical Study for New Drug Development, Lanzhou University, Lanzhou, China., Shen Y; Bloodworks Research Institute, Seattle, WA., Houck K; Bloodworks Research Institute, Seattle, WA., Yang M; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China., Zhou Y; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China., Zhao Z; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China., Wu X; Department of Pathology, University of Washington School of Medicine, Seattle, WA., Blevins T; Department of Comparative Medicine, Fred Hutch Cancer Center, Seattle, WA., Koehne AL; Department of Comparative Medicine, Fred Hutch Cancer Center, Seattle, WA., Wun TC; EVAS Therapeutics, LLC, Ballwin, MO; and., Fu X; Bloodworks Research Institute, Seattle, WA.; Division of Hematology, Department of Medicine, University of Washington, School of Medicine, Seattle, WA., Li M; Institute of Pathology, School of Medical Sciences and Gansu Provincial Key Laboratory of Preclinical Study for New Drug Development, Lanzhou University, Lanzhou, China., Zhang J; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China., Dong JF; Bloodworks Research Institute, Seattle, WA.; Division of Hematology, Department of Medicine, University of Washington, School of Medicine, Seattle, WA.

Publikováno v: Blood [Blood] 2021 Dec 23; Vol. 138 (25), pp. 2714-2726.

Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model.

Autor: O'Brien VP; Fred Hutchinson Cancer Research Center, Human Biology Division, Seattle, WA, USA., Koehne AL; Fred Hutchinson Cancer Research Center, Comparative Medicine Shared Resource, Seattle, WA, USA.; Fred Hutchinson Cancer Research Center, Experimental Histopathology Shared Resource, Seattle, WA, USA., Dubrulle J; Fred Hutchinson Cancer Research Center, Genomics and Bioinformatics Shared Resource, Seattle, WA, USA., Rodriguez AE; Fred Hutchinson Cancer Research Center, Human Biology Division, Seattle, WA, USA., Leverich CK; Fred Hutchinson Cancer Research Center, Human Biology Division, Seattle, WA, USA., Kong VP; Fred Hutchinson Cancer Research Center, Experimental Histopathology Shared Resource, Seattle, WA, USA., Campbell JS; Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA., Pierce RH; Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA., Goldenring JR; Department of Surgery, Epithelial Biology Center, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Nashville Veterans Affairs Medical Center, Nashville, TN, USA., Choi E; Department of Surgery, Epithelial Biology Center, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Salama NR; Fred Hutchinson Cancer Research Center, Human Biology Division, Seattle, WA, USA nsalama@fredhutch.org.

Publikováno v: Life science alliance [Life Sci Alliance] 2020 Dec 11; Vol. 4 (2). Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2021).

Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.

Autor: Kim JW; Department of Bioengineering, Stanford University, Stanford, CA, USA., Marquez CP; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; School of Medicine, Stanford University, Stanford, CA, USA., Kostyrko K; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Koehne AL; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; School of Medicine, Stanford University, Stanford, CA, USA.; Department of Comparative Medicine, Stanford University, Stanford, CA, USA., Marini K; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Simpson DR; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Lee AG; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Leung SG; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Sayles LC; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Shrager J; Division of Thoracic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Ferrer I; H120-CNIO Lung Cancer Clinical Research Unit, i+12 Research Institute, Spanish National Cancer Research Center and Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain., Paz-Ares L; H120-CNIO Lung Cancer Clinical Research Unit, i+12 Research Institute, Spanish National Cancer Research Center and Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain., Gephart MH; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA., Vicent S; Program in Solid Tumors and Biomarkers, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain., Cochran JR; Department of Bioengineering, Stanford University, Stanford, CA, USA. Jennifer.Cochran@stanford.edu., Sweet-Cordero EA; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Alejandro.Sweet-Cordero@ucsf.edu.

Publikováno v: Nature medicine [Nat Med] 2019 Nov; Vol. 25 (11), pp. 1783-1795. Date of Electronic Publication: 2019 Nov 07.