Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects

Autor: Kodigepalli Km, Uddalak Majumdar, Zhang X, Mansfield C, Madhumita Basu, Sathiyanarayanan Manivannan, Garg

Congenital heart disease (CHD) is the most prevalent structural malformations of the heart affecting ∼1% of live births. To date, both damaging genetic variations and adverse environmental exposure such as maternal diabetes have been found to cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::046f24a907e1ed0a3c5c34f901978159
https://doi.org/10.1101/2021.05.28.446177

Tgfβ1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury.

Autor: Nordquist EM; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus (E.M.N.).; Department of Pediatrics, Section of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).; The Herma Heart Institute, Children's Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.)., Dutta P; Department of Pediatrics, Section of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).; The Herma Heart Institute, Children's Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.)., Kodigepalli KM; Department of Pediatrics, Section of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).; The Herma Heart Institute, Children's Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.)., Mattern C; Department of Pediatrics, Section of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).; The Herma Heart Institute, Children's Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.)., McDermott MR; Center for Cardiovascular Research (M.R.M., A.J.T.), The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH.; The Heart Center, Nationwide Children's Hospital, Columbus, OH (M.R.M., A.J.T.)., Trask AJ; Center for Cardiovascular Research (M.R.M., A.J.T.), The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH.; The Heart Center, Nationwide Children's Hospital, Columbus, OH (M.R.M., A.J.T.).; Department of Pediatrics, The Ohio State University, Columbus (A.J.T.)., LaHaye S; The Institute for Genomic Medicine (S.L.), The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH., Lindner V; Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough (V.L.)., Lincoln J; Department of Pediatrics, Section of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).; The Herma Heart Institute, Children's Wisconsin, Milwaukee (E.M.N., P.D., K.M.K., C.M., J.L.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Dec; Vol. 41 (12), pp. 2923-2942. Date of Electronic Publication: 2021 Oct 14.

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway.

Autor: Dutta P; Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).; Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.)., Kodigepalli KM; Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).; Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.)., LaHaye S; The Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH (S.L.)., Thompson JW; Pharmacology and Cancer Biology, Duke University, Durham, NC (J.W.T., S.R.)., Rains S; Pharmacology and Cancer Biology, Duke University, Durham, NC (J.W.T., S.R.).; Duke Proteomics and Metabolomics Shared Resource, Durham, NC (S.R.)., Nagel C; Ocean Ridge Biosciences, Deerfield Beach, FL (C.N.)., Thatcher K; Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).; Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.)., Hinton RB; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, OH (R.B.H.)., Lincoln J; Department of Pediatrics, Medical College of Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).; Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee (P.D., K.M.K., K.T., J.L.).

Publikováno v: Circulation research [Circ Res] 2021 Apr 30; Vol. 128 (9), pp. 1300-1316. Date of Electronic Publication: 2021 Feb 19.

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.

Autor: Chen S; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210.; School of Basic Medical Sciences, Wuhan University, 430071 Wuhan, People's Republic of China., Bonifati S; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., Qin Z; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., St Gelais C; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., Kodigepalli KM; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., Barrett BS; Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045., Kim SH; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., Antonucci JM; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210., Ladner KJ; Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210., Buzovetsky O; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520., Knecht KM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520., Yount JS; Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH 43210., Guttridge DC; Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210., Santiago ML; Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045., Wu L; Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210; wu.840@osu.edu.; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210.; Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH 43210.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 17; Vol. 115 (16), pp. E3798-E3807. Date of Electronic Publication: 2018 Apr 02.

SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis.

Autor: Kodigepalli KM; a Center of Retrovirus Research, Department of Veterinary Biosciences , The Ohio State University , Columbus , OH , USA.; b Center for Cardiovascular Research , Nationwide Children's Hospital Research Institute , Columbus , OH , USA., Bonifati S; a Center of Retrovirus Research, Department of Veterinary Biosciences , The Ohio State University , Columbus , OH , USA., Tirumuru N; a Center of Retrovirus Research, Department of Veterinary Biosciences , The Ohio State University , Columbus , OH , USA., Wu L; a Center of Retrovirus Research, Department of Veterinary Biosciences , The Ohio State University , Columbus , OH , USA.; c Department of Microbial Infection and Immunity , The Ohio State University , Columbus , OH , USA.; d Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.

Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2018; Vol. 17 (9), pp. 1124-1137. Date of Electronic Publication: 2018 Jul 17.