A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings.

Autor: Del Rivero Morfin PJ; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Chavez DS; Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Jayaraman S; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Yang L; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Geisler SM; Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Tyrol, Austria., Kochiss AL; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Tuluc P; Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Tyrol, Austria., Colecraft HM; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA., Marx SO; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA., Liu XS; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Rajadhyaksha AM; Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Autism Research Program, Weill Cornell Medicine, New York, NY, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.

Publikováno v: Science advances [Sci Adv] 2024 Nov; Vol. 10 (44), pp. eadq3374. Date of Electronic Publication: 2024 Oct 30.

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of Ca V 1.3 Channels.

Autor: Del Rivero Morfin PJ; Department of Physiology and Cellular Biophysics, Columbia University., Kochiss AL; Department of Physiology and Cellular Biophysics, Columbia University., Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Flucher BE; Institute of Physiology, Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria., Fernández-Quintero MLI; Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 23. Date of Electronic Publication: 2023 Sep 23.