Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study.

Autor: Kochen NN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Seaney D; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Vasandani V; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Murray M; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Braun AR; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Sachs JN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: Proteins [Proteins] 2024 Jul; Vol. 92 (7), pp. 854-864. Date of Electronic Publication: 2024 Mar 08.

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors.

Autor: Braun AR; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Liao EE; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Horvath M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kalra P; Department of Chemistry, University of Minnesota, Minneapolis, MN, USA., Acosta K; Biochemistry & Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA, USA., Young MC; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Kochen NN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Lo CH; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Brown R; Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA., Evans MD; Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA., Pomerantz WCK; Department of Chemistry, University of Minnesota, Minneapolis, MN, USA., Rhoades E; Biochemistry & Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA., Luk K; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cornea RL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Photonic Pharma LLC, Minneapolis, MN, USA., Thomas DD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Photonic Pharma LLC, Minneapolis, MN, USA., Sachs JN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. jnsachs@umn.edu.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2021 Jun 28; Vol. 7 (1), pp. 52. Date of Electronic Publication: 2021 Jun 28.