Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight.

Autor: Koch, Ellen T.^1,2 (AUTHOR) ellen.koch@ucalgary.ca, Cheng, Judy^1,3 (AUTHOR), Ramandi, Daniel^1,4 (AUTHOR), Sepers, Marja D.¹ (AUTHOR), Hsu, Alex⁵ (AUTHOR), Fong, Tony^1,3 (AUTHOR), Murphy, Timothy H.¹ (AUTHOR), Yttri, Eric⁵ (AUTHOR), Raymond, Lynn A.¹ (AUTHOR)

Publikováno v: BMC Biology. 5/23/2024, Vol. 22 Issue 1, p1-19. 19p.

Axonal ER Ca²⁺ Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model.

Autor: Mackay, James P., Smith-Dijak, Amy I., Koch, Ellen T., Peng Zhang, Fung, Evan, Nassrallah, Wissam B., Buren, Caodu, Schmidt, Mandi, Hayden, Michael R., Raymond, Lynn A.

Publikováno v: Journal of Neuroscience; 5/17/2023, Vol. 43 Issue 20, p3743-3763, 21p

Spontaneous Axonal ER Ca2+ Waves Mediate A Shift From Action Potential-Dependent to Independent Glutamate Release in the YAC128 HD-Model

Autor: Mackay, James P., Buren, Caodu, Smith-Dijak, Amy I., Koch, Ellen T., Zhang, Peng, Schmidt, Mandi E., Fung, Evan, Nassrallah, Wissam B., Hayden, Michael R., Raymond, Lynn A.

Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Altered cortical glutamate release onto striatal spiny projection neurons (SPN) is thought to contribute to pa

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Axonal ER Ca ²⁺ Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model.

Autor: Mackay JP; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health., Smith-Dijak AI; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health.; Graduate Program in Neuroscience., Koch ET; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health.; Graduate Program in Neuroscience., Zhang P; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health.; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106., Fung E; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health., Nassrallah WB; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health.; MD/PhD Program., Buren C; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health.; Graduate Program in Neuroscience., Schmidt M; Graduate Program in Neuroscience.; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada., Hayden MR; Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada., Raymond LA; Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health Lynn.raymond@ubc.ca.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 May 17; Vol. 43 (20), pp. 3743-3763. Date of Electronic Publication: 2023 Mar 21.