Výsledky vyhledávání - "Kobulnicky, D."

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Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness in Clinical Outcomes Following Stem Cell Transplantation

Autor: Koparde, V, Razzaq, B Abdul, Suntum, T, Sabo, R, Scalora, A, Serrano, M, Jameson-Lee, M, Hall, C, Kobulnicky, D, Sheth, N, Sampson, J, Roberts, C, Buck, G, Neale, M, Toor, A

Publikováno v: PLoS One. 2017 Dec 1;12(12):e0187771

Alloreactivity following stem cell transplantation (SCT) is difficult to predict in patients undergoing transplantation from HLA matched donors. In this study we performed whole exome sequencing of SCT donor-recipient pairs (DRP). This allowed determ

Externí odkaz: http://arxiv.org/abs/1611.08956

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Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential In HLA-Matched and Mismatched Donor-Recipient Pairs

Autor: Razzaq, B. Abdul, Scalora, A., Koparde, V., Meier, J., Mahmood, M., Salman, S., Jameson-Lee, M., Serrano, M., Sheth, N., Voelkner, M., Kobulnicky, D., Roberts, C., Ferreira-Gonzalez, A., Manjili, M., Buck, G., Neale, M., Toor, A.

Stem cell transplants may be considered as dynamical systems to allow sequence differences across the exomes of the transplant donors and recipients to be used to simulate an alloreactive T cell response. Whole exome sequencing was performed on HLA m

Externí odkaz: http://arxiv.org/abs/1508.04416

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