Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.

Autor: Inoue K; Department of Social Epidemiology, Graduate School of Medicine Kyoto University Kyoto Japan.; Hakubi Center for Advanced Research Kyoto University Kyoto Japan., Naito T; Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan.; Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa Japan., Fuji R; Institute for Biomedicine (Affiliated to the University of Lübeck) Eurac Research Bolzano Italy.; Department of Preventive Medical Science Fujita Health University School of Medical Sciences Toyoake Japan., Sonehara K; Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan.; Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa Japan.; Department of Genome Informatics, Graduate School of Medicine The University of Tokyo Tokyo Japan., Yamamoto K; Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan., Baba R; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Kodama T; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Otagaki Y; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Okada A; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Itcho K; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Kobuke K; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Ohno H; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Morisaki T; Division of Molecular Pathology, Institute of Medical Science The University of Tokyo Tokyo Japan.; Department of Internal Medicine, Institute of Medical Science The University of Tokyo Hospital Tokyo Japan., Hattori N; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Goto A; Department of Public Health Yokohama City University Yokohama Japan., Nishikawa T; Endocrinology and Diabetes Center Yokohama Rosai Hospital Yokohama Japan., Oki K; Department of Molecular and Internal Medicine Hiroshima University Hiroshima Japan., Okada Y; Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan.; Laboratory for Systems Genetics RIKEN Center for Integrative Medical Sciences Yokohama Kanagawa Japan.; Department of Genome Informatics, Graduate School of Medicine The University of Tokyo Tokyo Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives Osaka University Suita Japan.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2024 Aug 06; Vol. 13 (15), pp. e034180. Date of Electronic Publication: 2024 Aug 05.

Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies.

Autor: Naito T; Department of Statistical Genetics, Graduate School of Medicine (T.N., K.S., K.Y., Y. Okada), Osaka University, Japan.; Department of Neurology (T.N.), University of Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (T.N., K.S., Y. Okada)., Inoue K; Department of Social Epidemiology, Graduate School of Medicine, Kyoto University, Japan (K.I.)., Sonehara K; Department of Statistical Genetics, Graduate School of Medicine (T.N., K.S., K.Y., Y. Okada), Osaka University, Japan.; Department of Genome Informatics (K.S., Y. Okada), University of Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (T.N., K.S., Y. Okada)., Baba R; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Kodama T; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Otagaki Y; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Okada A; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Itcho K; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Kobuke K; Department of Preventive Medicine for Diabetes and Lifestyle-Related Diseases (K.K.), Hiroshima University, Japan., Kishimoto S; Graduate School of Biomedical and Health Sciences, Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine (S.K., Y.H.), Hiroshima University, Japan., Yamamoto K; Department of Statistical Genetics, Graduate School of Medicine (T.N., K.S., K.Y., Y. Okada), Osaka University, Japan., Morisaki T; Graduate School of Medicine, Division of Molecular Pathology, Institute of Medical Science (T.M.), University of Tokyo, Japan.; Department of Internal Medicine, Institute of Medical Science, University of Tokyo Hospital, Japan (T.M.)., Higashi Y; Graduate School of Biomedical and Health Sciences, Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine (S.K., Y.H.), Hiroshima University, Japan., Hinata N; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan.; Department of Urology (N.H.), Hiroshima University, Japan., Arihiro K; Department of Anatomical Pathology, Hiroshima University Hospital, Japan (K.A.)., Hattori N; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan., Okada Y; Department of Statistical Genetics, Graduate School of Medicine (T.N., K.S., K.Y., Y. Okada), Osaka University, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (Y. Okada), Osaka University, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (Y. Okada), Osaka University, Japan.; Center for Infectious Disease Education and Research (Y. Okada), Osaka University, Japan.; Department of Genome Informatics (K.S., Y. Okada), University of Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (T.N., K.S., Y. Okada)., Oki K; Department of Molecular and Internal Medicine (R.B., T.K., Y. Otagaki, A.O., K.I., N.H., K.O.), Hiroshima University, Japan.

Publikováno v: Circulation [Circulation] 2023 Apr 04; Vol. 147 (14), pp. 1097-1109. Date of Electronic Publication: 2023 Feb 21.

Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma.

Autor: Kodama T; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Oki K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Otagaki Y; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Baba R; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Okada A; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Itcho K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Kobuke K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Nagano G; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Ohno H; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Hinata N; Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Arihiro K; Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan., Gomez-Sanchez CE; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, Mississippi, USA.; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Yoneda M; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Hattori N; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Publikováno v: Endocrine-related cancer [Endocr Relat Cancer] 2022 Jun 29; Vol. 29 (8), pp. 495-502. Date of Electronic Publication: 2022 Jun 29 (Print Publication: 2022).

Clinical and angiographic factors predicting fractional flow reserve and explaining the visual-functional mismatch in patients with intermediate coronary artery stenosis.

Autor: Watanabe H; Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine, Osakasayama, Japan., Onishi K, Kakehi K, Takase T, Yamaji K, Ueno M, Kobuke K, Miyazaki S, Iwanaga Y

Publikováno v: Coronary artery disease [Coron Artery Dis] 2020 Jan; Vol. 31 (1), pp. 73-80.

ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation.

Autor: Kobuke K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Oki K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Gomez-Sanchez CE; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, MS 39216, USA.; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA., Gomez-Sanchez EP; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA., Itcho K; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Ohno H; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Nagano G; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Yoshii Y; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Baba R; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Kodama T; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Arihiro K; Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima 734-8551, Japan., Hattori N; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan., Yoneda M; Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 12; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 12.