Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kobra, Haghighi"'
Autor:
Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2675 (2023)
Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to
Externí odkaz:
https://doaj.org/article/c3e75532ebfe4737b2a1a4a70797679d
Autor:
Elizabeth Vafiadaki, Kobra Haghighi, Demetrios A. Arvanitis, Evangelia G. Kranias, Despina Sanoudou
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6947 (2022)
Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human PLN mutation R14del has been identified in arrhythmogenic cardiomyopathy patients w
Externí odkaz:
https://doaj.org/article/4b8468dab14641dcac6eefa354b7d36b
Autor:
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano
Publikováno v:
Cardiovasc Res
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbedb98cc0fa6633afea4ced1ed20e3
https://doi.org/10.1093/cvr/cvac021
https://doi.org/10.1093/cvr/cvac021
Autor:
Malgorzata E, Rogalska, Elizabeth, Vafiadaki, Zoi, Erpapazoglou, Kobra, Haghighi, Lisa, Green, Christos S, Mantzoros, Roger J, Hajjar, Michael, Tranter, Ioannis, Karakikes, Evangelia G, Kranias, Francesca, Stillitano, Panagiota, Kafasla, Despina, Sanoudou
Publikováno v:
Metabolism. 138:155344
Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in the phospholamban (PLN) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ee103bf77e071c2c8e9a39b2435557
https://doi.org/10.1016/j.metabol.2022.155344
https://doi.org/10.1016/j.metabol.2022.155344
Autor:
Monica Alvisi, Timothy Henry, Eugene Chung, Jay Traverse, Leigh Ervin, Shiva Krupa, Hesham Sadek, Canwen Jiang, Sheila Mikhail, Kobra Haghighi, Evangelia Kranias, Jude Samulski, Anna Tretalova, Roger Hajjar
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77c68eb3fecff07ac6fa9ce730f4e818
https://doi.org/10.1016/j.yjmcc.2022.08.225
https://doi.org/10.1016/j.yjmcc.2022.08.225
Autor:
Ralph Knoell, Evangelia G. Kranias, Mohit Kumar, Kobra Haghighi, Sholeh Bazrafshan, Perundurai S. Dhandapany, Sakthivel Sadayappan, Rohit R. Singh
Publikováno v:
Circulation Research. 129
Rationale: Hypertrophic cardiomyopathy (HCM) is common inheritable heart disease. HCM is highly associated with arrhythmias and/or sudden death. Studies show that molecular defects in calcium handling impairing the cardiomyocyte contractility is a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6524c39284f820d9c6c918c201b49ce6
https://doi.org/10.1161/res.129.suppl_1.p348
https://doi.org/10.1161/res.129.suppl_1.p348
Autor:
George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26181058fcf099bc40c4dd72e341bce2
http://europepmc.org/articles/PMC6488766
http://europepmc.org/articles/PMC6488766
Autor:
Tracy J Pritchard, Yoshiaki Kawase, Kobra Haghighi, Ahmad Anjak, Wenfeng Cai, Min Jiang, Persoulla Nicolaou, George Pylar, Ioannis Karakikes, Kleopatra Rapti, Jack Rubinstein, Roger J Hajjar, Evangelia G Kranias
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80717 (2013)
Impaired sarcoplasmic reticulum calcium cycling and depressed contractility are key characteristics in heart failure. Defects in sarcoplasmic reticulum function are characterized by decreased SERCA2a Ca-transport that is partially attributable to dep
Externí odkaz:
https://doaj.org/article/914668e255514939a6d21b2a33846d2f
Publikováno v:
J Biol Chem
Cardiac myosin–binding protein-C (cMyBP-C) is highly phosphorylated under basal conditions. However, its phosphorylation level is decreased in individuals with heart failure. The necessity of cMyBP-C phosphorylation for proper contractile function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21a54846268d7d1b97fc1da4df5b537
https://pubmed.ncbi.nlm.nih.gov/32554466
https://pubmed.ncbi.nlm.nih.gov/32554466
Autor:
Elizabeth Vafiadaki, George Adly, Hongyan Zhu, Jack Rubinstein, Kobina Essandoh, George Gardner, Qiangrong Liang, Evangelia G. Kranias, Wenfeng Cai, Xiaohong Wang, Chi Keung Lam, Guan-Sheng Liu, Min Jiang, Kobra Haghighi, Despina Sanoudou, Guo-Chang Fan, Persoulla Nicolaou
Publikováno v:
Autophagy. 14:80-97
HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 (HSPB6S10F) exclusively present in dilated cardiomyopathy (DCM) patients. Cardiac e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3546eff57629a5d631f54b202b483af
https://doi.org/10.1080/15548627.2017.1392420
https://doi.org/10.1080/15548627.2017.1392420