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Akademický článek

The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia

Autor: Halima Al Balushi, Kobina Dufu, David C. Rees, John N. Brewin, Anke Hannemann, Donna Oksenberg, David C.‐Y. Lu, John S. Gibson

Publikováno v: Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)

Abstract Sickle cell anemia (SCA) is one of the commonest severe inherited disorders. Nevertheless, effective treatments remain inadequate and novel ones are avidly sought. A promising advance has been the design of novel compounds which react with h

Externí odkaz: https://doaj.org/article/9c3d3183d1f64aec9f3a922b887157e1

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Akademický článek

GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

Autor: Kobina Dufu, Donna Oksenberg

Publikováno v: Hematology Reports, Vol 10, Iss 2 (2018)

Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality. Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular injury are key events in the pathogenesis of sickle cell disease.

Externí odkaz: https://doaj.org/article/c192ce2c0b5a4fe58d016512ff18ff0c

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Akademický článek

GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exercise

Autor: Kobina Dufu, Josh Lehrer-Graiwer, Eleanor Ramos, Donna Oksenberg

Publikováno v: Hematology Reports, Vol 8, Iss 3 (2016)

In sickle cell trait (SCT), hemoglobin A (HbA) and S (HbS) are co-expressed in each red blood cell (RBC). While homozygous expression of HbS (HbSS) leads to polymerization and sickling of RBCs resulting in sickle cell disease (SCD) characterized by h

Externí odkaz: https://doaj.org/article/70541ac8da4246f3947b30f0a6921990

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Akademický článek

The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.

Autor: Eric G Folco, Chung-Sheng Lee, Kobina Dufu, Tomohiro Yamazaki, Robin Reed

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43804 (2012)

The conserved TREX complex, which contains UAP56, Aly, CIP29, and the multi-subunit THO complex, functions in mRNA export. Recently, several putative new components of the human TREX complex were identified by mass spectrometry. Here, we investigated

Externí odkaz: https://doaj.org/article/e0207041a596450a8fa95a214305f2c8

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Effects of an allosteric hemoglobin affinity modulator on arterial blood gases and cardiopulmonary responses during normoxic and hypoxic low-intensity exercise

Autor: Kobina Dufu, Timothy B. Curry, Bruce D. Johnson, Michael J. Joyner, Nicholas E. Vlahakis, Steven C. Chase, Josh Lehrer-Graiwer, Courtney M. Wheatley-Guy, Troy J. Cross, Glenn M. Stewart

Publikováno v: J Appl Physiol (1985)

Numerous pathophysiological conditions induce hypoxemia-related cardiopulmonary perturbations, decrements in exercise capacity, and debilitating symptoms. Accordingly, this study investigated the efficacy of an allosteric hemoglobin modulator (voxelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07383e95dff39677565eeee3a5bd0ce
https://doi.org/10.1152/japplphysiol.00185.2019

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