Zobrazeno 1 - 10 of 297 pro vyhledávání: '"Kobilka BK"'
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Akademický článek
Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR.
Autor: Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305., Chen G; Kobilka Institute of Innovative Drug Discovery, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305., Cao S; Kobilka Institute of Innovative Drug Discovery, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Heng J; Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing 100084, China., Deupi X; Condensed Matter Theory Group, Division of Scientific Computing, Theory, and Data, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Du Y; Kobilka Institute of Innovative Drug Discovery, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 26; Vol. 121 (48), pp. e2414544121. Date of Electronic Publication: 2024 Nov 20.
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5
Akademický článek
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.
Autor: Batebi H; Universität Leipzig, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, Leipzig, Germany.; Freie Universität Berlin, Fachbereich Physik, Berlin, Germany., Pérez-Hernández G; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany., Rahman SN; University of Copenhagen, Department of Drug Design and Pharmacology, Copenhagen, Denmark., Lan B; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Kamprad A; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany., Shi M; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Speck D; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany., Tiemann JKS; Universität Leipzig, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, Leipzig, Germany.; Novozymes A/S, Lyngby, Denmark., Guixà-González R; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany.; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain., Reinhardt F; Universität Leipzig, Department of Computer Science, Bioinformatics, Leipzig, Germany., Stadler PF; Universität Leipzig, Department of Computer Science, Bioinformatics, Leipzig, Germany., Papasergi-Scott MM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Skiniotis G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Scheerer P; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Mathiesen JM; University of Copenhagen, Department of Drug Design and Pharmacology, Copenhagen, Denmark., Liu X; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Hildebrand PW; Universität Leipzig, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, Leipzig, Germany. peter.hildebrand@medizin.uni-leipzig.de.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany. peter.hildebrand@medizin.uni-leipzig.de.
Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Nov; Vol. 31 (11), pp. 1692-1701. Date of Electronic Publication: 2024 Jun 12.
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6
Akademický článek
A µ-opioid receptor modulator that works cooperatively with naloxone.
Autor: O'Brien ES; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Rangari VA; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., El Daibani A; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Eans SO; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Hammond HR; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., White E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Shiimura Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan., Krishna Kumar K; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Jiang Q; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Appourchaux K; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Huang W; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhang C; Division of CryoEM and Bioimaging, SSRL, SLAC National Acceleration Laboratory, Menlo Park, CA, USA., Kennedy BJ; Lotus Separations, Princeton University, Princeton, NJ, USA., Mathiesen JM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Che T; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., McLaughlin JP; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. jpmclaughlin@ufl.edu., Majumdar S; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA. susrutam@wustl.edu., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.
Publikováno v: Nature [Nature] 2024 Jul; Vol. 631 (8021), pp. 686-693. Date of Electronic Publication: 2024 Jul 03.
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7
Akademický článek
Stepwise activation of a metabotropic glutamate receptor.
Autor: Krishna Kumar K; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kaavyak@stanford.edu., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Habrian C; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Latorraca NR; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., O'Brien ES; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhang C; Division of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Montabana E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Koehl A; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA., Marqusee S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Isacoff EY; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.
Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8013), pp. 951-956. Date of Electronic Publication: 2024 Apr 17.
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8
Author Correction: Stepwise activation of a metabotropic glutamate receptor.
Autor: Krishna Kumar K; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kaavyak@stanford.edu., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Habrian C; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Latorraca NR; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., O'Brien ES; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhang C; Division of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Montabana E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Koehl A; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA., Marqusee S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Isacoff EY; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.
Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8013), pp. E13.
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9
Akademický článek
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Autor: Zhao J; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.; Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China., Elgeti M; Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. matthias.elgeti@uni-leipzig.de.; Institute for Drug Discovery, University of Leipzig Medical Center, Leipzig, Germany. matthias.elgeti@uni-leipzig.de., O'Brien ES; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Sár CP; Institute of Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, University of Pécs, Pécs, Hungary., Ei Daibani A; Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA., Heng J; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.; Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China., Sun X; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.; Tsinghua-Peking Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China., White E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Che T; Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA., Hubbell WL; Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu., Chen C; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China. chunlai@mail.tsinghua.edu.cn.; School of Life Sciences, Tsinghua University, Beijing, China. chunlai@mail.tsinghua.edu.cn.
Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8011), pp. 474-480. Date of Electronic Publication: 2024 Apr 10.
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10
Akademický článek
Time-resolved cryo-EM of G-protein activation by a GPCR.
Autor: Papasergi-Scott MM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Pérez-Hernández G; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany., Batebi H; Institute of Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Leipzig, Germany., Gao Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Eskici G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Seven AB; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Panova O; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Hilger D; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Institute of Pharmaceutical Chemistry, Philipps-University of Marburg, Marburg, Germany., Casiraghi M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy., He F; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Maul L; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Hildebrand PW; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany.; Institute of Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Leipzig, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Skiniotis G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.
Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8014), pp. 1182-1191. Date of Electronic Publication: 2024 Mar 13.
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