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pro vyhledávání: '"Ko-bong Choi"'
Autor:
Ko-bong Choi, Chul Jung, Hyun Tae Kang, Hyo Jei Claudia Choi, Joon Tae Park, Young-Sam Lee, Gyu Ree Kim, Sang Chul Park
Publikováno v:
Aging Cell
Summary Hutchinson‐Gilford progeria syndrome (HGPS) constitutes a genetic disease wherein an aging phenotype manifests in childhood. Recent studies indicate that reactive oxygen species (ROS) play important roles in HGPS phenotype progression. Thus
Autor:
Chul Jung, Yongsub Kim, Young-Sam Lee, Ko-bong Choi, Sang Chul Park, Hyo Jei Claudia Choi, Joon Tae Park, Hyun Tae Kang
Publikováno v:
Nature chemical biology. 13(6)
Ataxia telangiectasia mutated (ATM) directly interacts with and phosphorylates the V-ATPase V1 subunit ATP6V1G1, thereby decreasing V1-V0 assembly in the V-ATPase. Attenuation of ATM activity results in lysosomal pH acidification, recovery of autopha