Výsledky vyhledávání - "Ko-Chung Lin"

Novel long‐acting ropeginterferon alfa‐2b: Pharmacokinetics, pharmacodynamics and safety in a phase I clinical trial

Autor: Yi‐Wen Huang, Albert Qin, Jane Fang, Ting‐Fang Wang, Chung‐Wei Tsai, Ko‐Chung Lin, Ching‐Leou Teng, Richard Larouche

Publikováno v: British Journal of Clinical Pharmacology. 88:2396-2407

Ropeginterferon alfa-2b is a novel, long-acting pegylated interferon alfa-2b. We aimed to evaluate its safety, pharmacokinetics (PK) and pharmacodynamics (PD).Thirty-six subjects received single subcutaneous injection of ropeginterferon alfa-2b at do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14029c4bde252940c49436f1509fb438
https://doi.org/10.1111/bcp.15176

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Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists

Autor: Melissa Tam, Xiaowei Jin, Ko-Chung Lin, Jianbo Zhang, Patrick Conlon, Chi Vu, Liqing Chen, Glenn Smits, William F. Kiesman, Petter Russell C, Frank Lutterodt

Publikováno v: Journal of Medicinal Chemistry. 49:7132-7139

Novel tricyclic imidazoline antagonists of the adenosine A1 receptor are described. For key compounds, the selectivity level over other adenosine receptor subtypes is examined along with their in vivo effects in a rat diuresis model. Compound 14, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbe8d0c9576170f9f267ffab6bfba78
https://doi.org/10.1021/jm060539t

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[Untitled]

Autor: Rex A. Palmer, Cuervo Julio Hernan, Zimmerman Craig N, Tapan K. Chattopadhyay, Juswinder Singh, Ko-Chung Lin, Wen-Cherng Lee, Michael Karpusas, Steven P. Adams, Humayun Saleem Ateeq, Hammond Charles E, Yu-Sheng Liao, Herman W. T. van Vlijmen

Publikováno v: Journal of Computer-Aided Molecular Design. 16:201-211

The integrin VLA-4 (alpha4,beta1) is involved in the migration of white blood cells to sites of inflammation, and is implicated in the pathology of a variety of diseases including asthma and multiple sclerosis. We report the structure-activity relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::303bd387b80763116db899fa6fe03cd2
https://doi.org/10.1023/a:1020130418084

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Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking

Autor: Steve Adams, R B Pepinsky, L. L. Chen, Roy R. Lobb, Ko-Chung Lin, J. H. Cuervo

Publikováno v: Biochemistry. 37:8743-8753

We have used chemical cross-linking to identify sequences in integrin alpha4beta1 that are involved in its interactions with ligands. A recently described leucine-aspartic acid-valine (LDV)-based small molecule inhibitor of alpha4beta1 (BIO-1494), th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3c68df7c7fa5a16ae039cfc8818edc
https://doi.org/10.1021/bi980311a

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EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics

Autor: Darryl G. Cleary, Kenneth J. Gruys, James A. Sikorski, Joel E. Ream, Paul D. Pansegrau, Michael J. Miller, C. Y. Han, R. Douglas Sammons, Diane Susan Braccolino, Ko-Chung Lin, Karen S. Anderson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1435-1440

Studies using alternate substrates, inhibitor product mimics and new derivatives of 4,5-dideoxy-shikimate-3-phosphate (ddS3P) are reported which indicate that the 3-phosphate group contributes significantly to substrate and inhibitor recognition at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::755ba7413f8fd2e8b53b28cf70d6e711
https://doi.org/10.1016/s0960-894x(01)80425-x

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EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

Autor: Kenneth J. Gruys, Michael J. Miller, C. Y. Han, Mark C. Walker, Dora M. Schnur, Ko-Chung Lin, Jose L. Font, Paul D. Pansegrau, Susan D. Corey, Diane Susan Braccolino, James A. Sikorski, Ajit S. Shah, D. G. Cleary, Joel E. Ream

Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 76:115-118

Novel aromatic bisubstrate inhibitors of the enzyme EPSP (5-enolpyruvoylshikimate-3-phosphate) synthase (EC 2.5.1.19) have been designed and synthesized as structural analogs of the single, catalytic intermediate 1 utilized by the enzyme. These aroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d6b80ad3beef91b4061e80035eee22b
https://doi.org/10.1080/10426509308032372

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ChemInform Abstract: EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

Autor: Michael J. Miller, C. Y. Han, Kenneth J. Gruys, James A. Sikorski, Ko-Chung Lin, Joel E. Ream, Paul D. Pansegrau, D. G. Cleary, Mark C. Walker, Diane Susan Braccolino, Dora M. Schnur, Jose L. Font, Susan D. Corey, Ajit S. Shah

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a59aa2daa944c35ccba79382aedebaf
https://doi.org/10.1002/chin.199335301

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The preeminence of clusters

Autor: Mark Leuchtenberger, Pedro de Noronha Pissarra, C Mark Tang, Ko-Chung Lin, Pratik Shah, Fritz R. Bühler

Publikováno v: Bioentrepreneur.

Many cities and countries still view the foundation of a biotech sector as desirable for a high-tech, intellectually driven economy. But a discussion by seasoned biotech management and investors suggests that attaining an environment with the right m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad28e0405c56ae003d40052916083d7
https://doi.org/10.1038/bioe.2007.4

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