Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ko Morishita"'
Autor:
Yuma Ito, Masaki Fukui, Mamoru Kanda, Ko Morishita, Yoshimichi Shoji, Tatsuya Kitao, Eiichi Hinoi, Hiroaki Shirahase
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 38-46 (2018)
The anti-diabetic and anti-obesity effects of the allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide (KY-226) were pharmacologically evaluated. KY-226 inhibited human P
Externí odkaz:
https://doaj.org/article/27923f6ad7b74318827ed6a19e8b5570
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Autor:
Tatsuya Kitao, Tomohiro Miike, Takeda Shigemitsu, Yuma Ito, Shin-ichiro Ozawa, Masaki Fukui, Shuichi Hirono, Ko Morishita, Hiroaki Shirahase
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:1211-1224
A novel series of 2,6,7-substituted 3-unsubstituted 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized to find a peroxisome proliferator-activated receptor γ (PPARγ) partial agonist. Among the derivatives, (E)-7-[2-(cyclopent-3-eny)-5-meth
Autor:
Yoshimichi Shoji, Masaki Fukui, Hiroaki Shirahase, Yuma Ito, Shin-ichiro Ozawa, Ko Morishita, Tatsuya Kitao, Shuichi Hirono
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:1131-1152
A novel series of 2-acyl-3-carboxyl-tetrahydroisoquinoline derivatives were synthesized and biologically evaluated. Among them, (S)-2-{(E)-3-furan-2-ylacryloyl}-7-[(2E,4E)-5-(2,4,6-trifluorophenyl)penta-2,4-dienyloxy]-1,2,3,4-tetrahydroisoquinoline-3
Autor:
Mamoru Kanda, Yuma Ito, Yoshimichi Shoji, Masaki Fukui, Ko Morishita, Hiroaki Shirahase, Tatsuya Kitao, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 38-46 (2018)
The anti-diabetic and anti-obesity effects of the allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide (KY-226) were pharmacologically evaluated. KY-226 inhibited human P
Autor:
Shuichi Hirono, Masaki Fukui, Hiroaki Shirahase, Yuma Ito, Shin-ichiro Ozawa, Yoshimichi Shoji, Tatsuya Kitao, Shunkichi Tanaka, Ko Morishita
Publikováno v:
Scopus-Elsevier
A novel series of benzoylsulfonamide derivatives were synthesized and biologically evaluated. Among them, 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzamide (compound 18K) was identified as a protein tyrosine phosphatase 1B (PTP1B)
Autor:
Tsubasa Inokuma, Hao Ding, Ko Morishita, Akira Shigenaga, Akira Otaka, Chiaki Komiya, Keisuke Aihara
Publikováno v:
The Journal of Organic Chemistry. 81(2):699-707
A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorpor
Autor:
Hao Ding, Kohei Sato, Keiko Yamaguchi, Koji Ebisuno, Akira Shigenaga, Jun Yamamoto, Akira Otaka, Kenichi Akaji, Ko Morishita
Publikováno v:
Tetrahedron. 67:8879-8886
Cysteine proteases are attractive drug targets due to their involvement in a wide variety of diseases. To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable. In t
Autor:
Keiji Ogura, Nami Maeda, Akira Otaka, Ko Morishita, Hiroko Hirakawa, Jun Yamamoto, Akira Shigenaga
Publikováno v:
Tetrahedron Letters. 51:2525-2528
To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced rel
Publikováno v:
Organic letters. 13(20)
Dual kinetically controlled native chemical ligation using a newly developed sulfanylproline-mediated reaction in combination with an N-sulfanylethylanilide peptide was successfully applied to a previously unreported sequential coupling of peptide fr