Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Ko Jie Chen"'
2
Inhaled liposomal treprostinil (L606) shows extended release in healthy volunteer, as well as prolongs pharmacological effect in hypoxia-induced rat
Autor: Pei Kan, Ko-Jie Chen, Cleo Pan
Publikováno v: Pulmonary hypertension.
Background: Current inhaled prostacyclin products have a short plasma half-life and require frequent dosing, resulting in high peak-trough fluctuation. Aim: Liposome formulation is employed to provide sustained plasma concentration, which is expected
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3323f9b92c5b37bc8d0089b39eb22a63
https://doi.org/10.1183/13993003.congress-2020.1480
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3
Inhaled liposomal iloprost shows high drug encapsulation, extended release profile and potentials of improving patient compliance
Autor: Yi-Fong Lin, Ko-Jie Chen, Chin-Feng Hsu, Pei Kan
Publikováno v: Pulmonary hypertension.
Background: Iloprost is a prostacyclin (PGI2) analog for treatment of pulmonary arterial hypertension. The iloprost inhalation product, Ventavis®, has a short plasma half-life and requires frequent dosing (6-9 times per day). Moreover, iloprost ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac55d05f72437766b27df4384035d51d
https://doi.org/10.1183/13993003.congress-2018.pa3038
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4
An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance
Autor: Zi-Xian Liao, Hao Ji Wei, Er-Tuan Chuang, Po-Yuan Cheng, Kun-Ju Lin, Hsing-Wen Sung, Yi Cheng Ho, Ko Jie Chen, Chia Chen Lin
Publikováno v: Journal of Controlled Release. 208:42-51
Recent research in chemotherapy has prioritized overcoming the multidrug resistance (MDR) of cancer cells. In this work, liposomes that contain doxorubicin (DOX) and ammonium bicarbonate (ABC, a bubble-generating agent) are prepared and functionalize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de34769f1231b566c08fa814204e0d5d
https://doi.org/10.1016/j.jconrel.2015.01.032
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5
Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy
Autor: Ming Cheng Wei, Shiaw-Pyng Wey, Kun-Ju Lin, Chun Min Liu, Hsiang-Wen Tseng, Hao-Li Liu, Chia Chen Lin, Chih Peng Liu, Hsing-Wen Sung, Ko Jie Chen, Felice Cheng, Er Yuan Chaung
Publikováno v: ACS Nano. 8:5105-5115
As is widely suspected, lysolipid dissociation from liposomes contributes to the intravenous instability of ThermoDox (lysolipid liposomes), thereby impeding its antitumor efficacy. This work evaluates the feasibility of a thermoresponsive bubble-gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d74564d5d3f82874c9fd4e5fae9cace
https://doi.org/10.1021/nn501162x
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6
The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium
Autor: Harry Rakowski, Hsing-Wen Sung, Chia-Wen Huang, Ko-Jie Chen, Ren-Ke Li, Jun Wu, Lu Sun, Richard D. Weisel, Shu-Hong Li
Publikováno v: Biomaterials. 34:2107-2116
We synthesized a cationic microbubble (CMB) with the aim of enhancing its DNA-carrying capacity to improve targeted gene transfection of the ischemic heart for cardiac regeneration. We previously reported that ultrasound-targeted microbubble destruct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fd194b074518699bd663dc40196a83
https://doi.org/10.1016/j.biomaterials.2012.11.041
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8
A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release
Autor: Er-Tuan Chuang, Yi Cheng Ho, Kun-Ju Lin, Chia Chen Lin, Hsing-Wen Sung, Ko Jie Chen, Dehui Wan, Po Yen Lin
Publikováno v: Biomaterials. 93
The nonspecific distribution of therapeutic agents and nontargeted heating commonly produce undesirable side effects during cancer treatment since the optimal timing of triggering the carrier systems is unknown. This work proposes a multifunctional l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f74df5991d376fc570d046fa73722d
https://pubmed.ncbi.nlm.nih.gov/27070992
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9
Intracellularly monitoring/imaging the release of doxorubicin from pH-responsive nanoparticles using Förster resonance energy transfer
Autor: Yu-Ming Chen, Hsing-Wen Sung, Ko-Jie Chen, Ya-Ling Chiu, Yi Cheng Ho
Publikováno v: Biomaterials. 32:2586-2592
Stimuli-responsive nanoparticles (NPs) have been receiving much attention as a drug-delivery vehicle for therapeutic applications; once internalized into cells, the intracellular fate of NPs and their drug release behavior in response to local stimul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b18aa3145696d6858fd1af7956341c3
https://doi.org/10.1016/j.biomaterials.2010.11.069
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10
A Dual-Emission Förster Resonance Energy Transfer Nanoprobe for Sensing/Imaging pH Changes in the Biological Environment
Autor: Ko-Jie Chen, Hsing-Wen Sung, Jean-Hong Chen, Hsin-Lung Chen, Ya-Ling Chiu, Show-An Chen
Publikováno v: ACS Nano. 4:7467-7474
A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac06ce89fd69df35e5914ad60720508
https://doi.org/10.1021/nn102644u
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