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Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines.

Autor: An YJ; Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea., Jung YE; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea., Lee KW; Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea., Kaushal P; Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic Korea., Ko IY; New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea., Shin SM; Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea., Ji S; Department of Brain Sciences, DGIST, Daegu, Republic of Korea., Yu W; Department of Brain Sciences, DGIST, Daegu, Republic of Korea., Lee C; Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic Korea., Lee WK; New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea., Cha K; New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea., Lee JH; Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea., Cha SS; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea., Yim HS; Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea.

Publikováno v: PloS one [PLoS One] 2024 Sep 05; Vol. 19 (9), pp. e0307499. Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).

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Akademický článek

Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants.

Autor: Kim JW; Department of Biochemistry, Kookmin University, Seoul, 02707, Republic of Korea., Heo K; Department of Biochemistry, Kookmin University, Seoul, 02707, Republic of Korea; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea; Antibody Research Institute, Kookmin University, Seoul, 02707, Republic of Korea., Kim HJ; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Yoo Y; Department of Systems Biology, Yonsei University, Seoul, 03722, Republic of Korea., Cho HS; Department of Systems Biology, Yonsei University, Seoul, 03722, Republic of Korea., Jang HJ; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul, 13620, Republic of Korea., Lee HY; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul, 13620, Republic of Korea., Ko IY; New Drug Development Center, KBIOHealth, Cheongju, 28160, Republic of Korea., Woo JR; New Drug Development Center, KBIOHealth, Cheongju, 28160, Republic of Korea., Cho YB; Department of Biochemistry, Kookmin University, Seoul, 02707, Republic of Korea., Lee JH; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Yang HR; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Shin HG; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Choi HL; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Hwang K; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea., Kim S; Research Center, KNOTUS Co. Ltd., Incheon, 22014, Republic of Korea., Kim H; Baobab AiBIO, POSCO Green Building, Yonsei University, Incheon, 21983, Republic of Korea., Chun K; R&D Center, Binex, Incheon, 21999, Republic of Korea., Lee S; Department of Biochemistry, Kookmin University, Seoul, 02707, Republic of Korea; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul, 02707, Republic of Korea; Antibody Research Institute, Kookmin University, Seoul, 02707, Republic of Korea. Electronic address: lees2018@kookmin.ac.kr.

Publikováno v: Antiviral research [Antiviral Res] 2023 Apr; Vol. 212, pp. 105576. Date of Electronic Publication: 2023 Mar 02.

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Akademický článek

Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity.

Autor: Lee KW; Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, Busan, 49111, Republic of Korea., An YJ; Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, Busan, 49111, Republic of Korea., Lee J; Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, Busan, 49111, Republic of Korea., Jung YE; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea., Ko IY; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, 28160, Republic of Korea., Jin J; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, 28160, Republic of Korea., Park JH; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, 28160, Republic of Korea., Lee WK; New Drug Development Center, Osong Medical Innovation Foundation, Cheongju, 28160, Republic of Korea., Cha K; EHLBio, Uiwang, 16006, Republic of Korea., Ko SC; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea., Lee JH; Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, Busan, 49111, Republic of Korea. jlee@kiost.ac.kr.; Department of Marine Biotechnology, Korea University of Science and Technology, Daejeon, 34113, Republic of Korea. jlee@kiost.ac.kr., Yim HS; Marine Biotechnology Research Center, Korea Institute of Ocean Science and Technology, Busan, 49111, Republic of Korea. yimh@kiost.ac.kr.

Publikováno v: Journal of microbiology (Seoul, Korea) [J Microbiol] 2022 Nov; Vol. 60 (11), pp. 1086-1094. Date of Electronic Publication: 2022 Nov 01.

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Akademický článek

Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation.

Autor: Koo BH; Department of Biological Sciences, Kangwon National University, Chuncheon, Korea., Yi BG; Department of Biological Sciences, Kangwon National University, Chuncheon, Korea., Wang WK; Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea., Ko IY; Department of Medical Biotechnology, Kangwon National University, Chuncheon, Korea., Hoe KL; Department of New Drug Discovery and Development, Chungnam National University, Daejeon, Korea., Kwon YG; Department of Biochemistry, Yonsei University, Seoul, Korea., Won MH; Department of Neurobiology, Kangwon National University, Chuncheon, Korea., Kim YM; Department of Molecular and Cellular Biochemistry, Kangwon National University, Chuncheon, Korea., Lim HK; Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. hyunkyolim@yonsei.ac.kr., Ryoo S; Department of Biological Sciences, Kangwon National University, Chuncheon, Korea. ryoosw08@kangwon.ac.kr.

Publikováno v: Yonsei medical journal [Yonsei Med J] 2018 May; Vol. 59 (3), pp. 366-375.

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