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Akademický článek

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

Autor: Lin Pan, Amelia Trimarco, Alice J Zhang, Ko Fujimori, Yoshihiro Urade, Lu O Sun, Carla Taveggia, Ye Zhang

Publikováno v: eLife, Vol 12 (2023)

In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenc

Externí odkaz: https://doaj.org/article/8adbcb1ecf924139b56a96be47350b1c

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Akademický článek

Anti-obesity effects of Asian dayflower, Commelina communis, in mice with high-fat diet-induced obesity and in 3T3-L1 cells

Autor: Shiori Nagai, Eri Wakai, Makio Shibano, Ko Fujimori

Publikováno v: Journal of Functional Foods, Vol 22, Iss , Pp 490-503 (2016)

Asian dayflower, Commelina communis tea (CCT), decreased the body weight gain and reduced the mass of visceral and subcutaneous adipose tissue in the high-fat diet (HFD)-fed mice. The serum glucose and triacylglycerol levels were lowered in CCT-admin

Externí odkaz: https://doaj.org/article/67368cdf45ef4adf8e1089f9c33d9c2d

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Akademický článek

Influence of the culture medium on the production of nitric oxide and expression of inducible nitric oxide synthase by activated macrophages in vitro

Autor: Tomoya Kawakami, Kana Kawamura, Ko Fujimori, Atsushi Koike, Fumio Amano

Publikováno v: Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 328-334 (2016)

Macrophages play an important role in immune and inflammatory responses, and have been extensively studied in vitro using culture media such as RPMI1640 medium, Dulbecco's modified Eagle medium (DMEM), and Ham's F-12 medium (F-12). We found that the

Externí odkaz: https://doaj.org/article/da02642ac057457d857257c8eac618d8

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Akademický článek

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Autor: Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

Publikováno v: Molecules, Vol 24, Iss 22, p 4155 (2019)

The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biological processes including bile acid metabolism, and are associated with the control of fatty liver and osteoporosis. Thus, the control of FXR activity and devel

Externí odkaz: https://doaj.org/article/61ac62be565e4b98b0703e5e1d8f2c69

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Akademický článek

A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression

Autor: Chihiro Matsumoto, Atsushi Koike, Reiko Tanaka, Ko Fujimori

Publikováno v: Molecules, Vol 24, Iss 9, p 1668 (2019)

Limonoids are phytochemicals with a variety of biological properties. In the present study, we elucidated the molecular mechanism of suppression of adipogenesis in adipocytes by a limonoid, 7-deacetoxy-7-oxogedunin (CG-1) from Carapa guianensis (Meli

Externí odkaz: https://doaj.org/article/909dd6a759374dcb8db04493477062ca

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Akademický článek

Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals.

Autor: Tomoaki Bessho, Tetsuya Okada, Chihiro Kimura, Takahiro Shinohara, Ai Tomiyama, Akira Imamura, Mitsuru Kuwamura, Kazuhiko Nishimura, Ko Fujimori, Satoshi Shuto, Osamu Ishibashi, Bruno Kilunga Kubata, Takashi Inui

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004339 (2016)

The metabolic pathway of purine nucleotides in parasitic protozoa is a potent drug target for treatment of parasitemia. Guanosine 5'-monophosphate reductase (GMPR), which catalyzes the deamination of guanosine 5'-monophosphate (GMP) to inosine 5'-mon

Externí odkaz: https://doaj.org/article/8cd7383089a2418681963d410a9596ac

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Akademický článek

Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPα-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes.

Autor: Yukari Nakao, Hideto Yoshihara, Ko Fujimori

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163640 (2016)

Baicalein has been used as a Chinese medicine, and is an abundant plant flavonoid present in fruits and vegetables. Here, we examined the effects of baicalein in adipogenesis and investigated its molecular mechanism in adipocytes. Baicalein lowered t

Externí odkaz: https://doaj.org/article/36f66e80a1cb4573872aefbb6a45eda6

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Akademický článek

Prostaglandins as PPARγ Modulators in Adipogenesis

Autor: Ko Fujimori

Publikováno v: PPAR Research, Vol 2012 (2012)

Adipocytes and fat cells play critical roles in the regulation of energy homeostasis. Adipogenesis (adipocyte differentiation) is regulated via a complex process including coordinated changes in hormone sensitivity and gene expression. PPARγ is a li

Externí odkaz: https://doaj.org/article/149a9ccbd84047df916e8baea6f47161

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Akademický článek

Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)-produced PGE2 and aldo-keto reductase 1B3-produced PGF2α.

Autor: Ko Fujimori, Mutsumi Yano, Toshiyuki Ueno

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44698 (2012)

We recently reported that aldo-keto reductase 1B3-produced prostaglandin (PG) F(2α) suppressed the early phase of adipogenesis. PGE(2) is also known to suppress adipogenesis. In this study, we found that microsomal PGE(2) synthase (PGES)-1 (mPGES-1;

Externí odkaz: https://doaj.org/article/7a0b16b974d74f53b904a484a57b0bc3

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