Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Knut Teigen"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Several existing β2-adrenergic agonists and antagonists, as well as the atypical antipsychotic ziprasidone, are identified as high affinity VMAT2 inhibitors, which could have implications for drug repurposing and drug derivatization campaigns.
Externí odkaz:
https://doaj.org/article/7ed0084c4c2445e5b0f56f19fe43d40b
Autor:
María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline. Here, the authors present the cryo-EM structures of full-length human TH in t
Externí odkaz:
https://doaj.org/article/3b54c91d09444b37ba25ca02cc815dcd
Autor:
Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavik
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT synthesis is catalyzed by try
Externí odkaz:
https://doaj.org/article/441f33ddf4ad4ea2ae91b5c0606f75b8
Autor:
Olena Dobrovolska, Øyvind Strømland, Ørjan Sele Handegård, Martin Jakubec, Morten L. Govasli, Åge Aleksander Skjevik, Nils Åge Frøystein, Knut Teigen, Øyvind Halskau
Publikováno v:
Molecules, Vol 26, Iss 12, p 3607 (2021)
The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric polypeptide, A-Cage-C, derived
Externí odkaz:
https://doaj.org/article/42ec77364dd5428b97e354bec2f9e8a2
Publikováno v:
FEBS Open Bio, Vol 7, Iss 7, Pp 1026-1036 (2017)
Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and a high ac
Externí odkaz:
https://doaj.org/article/42c8efbce0d54fe8ac7f5f75f891e932
Autor:
Lars Herfindal, Frode Selheim, Stein Ove Døskeland, Øystein Bruserud, Anders Brunsvik, Kolbjørn Zahlsen, Kristin F. Degnes, Knut Teigen, Håvard Sletta, Gro Gausdal, Lene E. Myhren, Gyrid Nygaard
Publikováno v:
Marine Drugs, Vol 11, Iss 2, Pp 332-349 (2013)
Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacteriu
Externí odkaz:
https://doaj.org/article/7c8a8ce1b6c144dbb64b236c4b548c9d
Autor:
Lars Herfindal, Camilla Krakstad, Lene Myhren, Hanne Hagland, Reidun Kopperud, Knut Teigen, Frank Schwede, Rune Kleppe, Stein Ove Døskeland
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94926 (2014)
Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G (PKG). We report here that som
Externí odkaz:
https://doaj.org/article/61af7002329d499bb1b38422a66f7f44
Autor:
Lars Skjaerven, Barry Grant, Arturo Muga, Knut Teigen, J Andrew McCammon, Nathalie Reuter, Aurora Martinez
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1002004 (2011)
GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized from extensive crystallogra
Externí odkaz:
https://doaj.org/article/4dd297e046af4b9990cbbd9c6db2f83c
Autor:
Khanh K Dao, Angel L Pey, Anja Underhaug Gjerde, Knut Teigen, In-Ja L Byeon, Stein O Døskeland, Angela M Gronenborn, Aurora Martinez
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17602 (2011)
BackgroundThe regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rathe
Externí odkaz:
https://doaj.org/article/31c7d72bd67e4781abe6317a5e2de01e
Autor:
Nils Halberg, Knut Teigen, Anders Molven, Philipp E. Scherer, Ruth Gordillo, Per Eystein Lønning, Stian Knappskog, Muntequa I. Siraji, Pouda Panahandeh, Line Pedersen
The metabolic network of sphingolipids plays important roles in cancer biology. Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis, and cellular signaling. Although a significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317fa6318b4eab3c4312f92a9bb80d81
https://doi.org/10.1158/0008-5472.c.6511533
https://doi.org/10.1158/0008-5472.c.6511533
