Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Knut Sturmhoefel"'
Autor:
Ron L. Peterson, Andrew J. Dorner, Knut Sturmhoefel, Margot O'Toole, Stanley F. Wolf, Holly Swiniarski
Publikováno v:
Clinical Immunology. 94:200-211
The effect of in vivo administration of rmIL-12 on the CTL response to immunization with a weakly immunogenic class I-restricted peptide emulsified in incomplete Freund's adjuvant was investigated. In the absence of IL-12, peptide-specific CTL respon
Autor:
Knut Sturmhoefel, Stanley F. Wolf, Kwang Lee, Holly Swiniarski, Andrew J. Dorner, Margot O'Toole
Publikováno v:
Journal of Immunological Methods. 233:1-11
In this paper, we present a method for measuring antigen specific cytotoxic T lymphocyte (CTL) activity from individual mouse peripheral blood samples without animal sacrifice. Peripheral blood cells are stimulated in vitro with a cocktail of antigen
Autor:
Kwang Lee, Holly Swiniarski, Gary S. Gray, Andrew J. Dorner, Jenifer L. Thomas, Margot O'Toole, Knut Sturmhoefel, Stanley F. Wolf
Publikováno v:
Clinical Immunology. 92:235-245
The identification of both class I- and class II-restricted tumor-associated peptides recognized by T cells has led to the test of these peptides as immunogens in experimental immunotherapy for cancer patients. However, optimal T cell activation requ
Autor:
Patrick E. Fields, Rosalynde J. Finch, Gary S. Gray, Richard Zollner, Jenifer L. Thomas, Knut Sturmhoefel, Kwan Lee, Stanley Wolf, Thomas F. Gajewski, Frank W. Fitch
Publikováno v:
The Journal of Immunology. 161:5268-5275
Using a TCR transgenic mouse bred onto a recombinase-activating gene-2-deficient background, we have examined the influence of B7.1 and B7.2 on activation of naive, CD8+ T cells in vitro. We found that B7.1 was a more potent costimulus than B7.2 for
Autor:
Knut Sturmhoefel, Margot O'Toole, Kwang Lee, Stanley F. Wolf, Willem W. Overwijk, Andrew J. Dorner, Holly Swiniarski, Nicholas P. Restifo
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 20(6)
Interleukin-12 (IL-12) has been shown to play a central role in the innate and acquired immune responses. Its activities include enhancement of natural killer (NK) and cytotoxic T lymphocyte (CTL) activity and promotion of CD4 Th1 cell development. I
Autor:
Sturmhoefel, K., Harstrick, A.
Publikováno v:
Der Onkologe; Nov2001, Vol. 7 Issue 11, p1220-1228, 9p
Publikováno v:
Immunological Investigations; 2000, Vol. 29 Issue 2, p143-146, 4p
An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuva