Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Knut Reinert"'
Autor:
Chenxu Pan, Knut Reinert
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Advances in sequencing technology have facilitated population-scale long-read structural variant (SV) detection. Arguably, one of the main challenges in population-scale analysis is developing effective computational pipelines. Here, we pres
Externí odkaz:
https://doaj.org/article/11e1c9a118464ffe92db09988b93ca6a
Autor:
Svenja Mehringer, Enrico Seiler, Felix Droop, Mitra Darvish, René Rahn, Martin Vingron, Knut Reinert
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract We present a novel data structure for searching sequences in large databases: the Hierarchical Interleaved Bloom Filter (HIBF). It is extremely fast and space efficient, yet so general that it could serve as the underlying engine for many ap
Externí odkaz:
https://doaj.org/article/f6096bb2c23c40cc92f2bd277d69761a
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background The function of non-coding RNA sequences is largely determined by their spatial conformation, namely the secondary structure of the molecule, formed by Watson–Crick interactions between nucleotides. Hence, modern RNA alignment a
Externí odkaz:
https://doaj.org/article/f1fe5a027864460d85056977030019a8
Autor:
Kerstin Neubert, Eric Zuchantke, Robert Maximilian Leidenfrost, Roebbe Wuenschiers, Josephine Grützke, Burkhard Malorny, Holger Brendebach, Sascha Al Dahouk, Timo Homeier, Helmut Hotzel, Knut Reinert, Herbert Tomaso, Anne Busch
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background We benchmarked sequencing technology and assembly strategies for short-read, long-read, and hybrid assemblers in respect to correctness, contiguity, and completeness of assemblies in genomes of Francisella tularensis. Benchmarking
Externí odkaz:
https://doaj.org/article/c30de5e7596e46d2b4a57628b591e229
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102782- (2021)
Summary: We present Raptor, a system for approximately searching many queries such as next-generation sequencing reads or transcripts in large collections of nucleotide sequences. Raptor uses winnowing minimizers to define a set of representative k-m
Externí odkaz:
https://doaj.org/article/2ddb8bd4ab5341bfbb7e299fd659e570
Publikováno v:
BMC Biotechnology, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Natural variations in a genome can drastically alter the CRISPR-Cas9 off-target landscape by creating or removing sites. Despite the resulting potential side-effects from such unaccounted for sites, current off-target detection pi
Externí odkaz:
https://doaj.org/article/55f4d2c5b2be44949d621446f89d79f8
Autor:
M-Hossein Moeinzadeh, Jun Yang, Evgeny Muzychenko, Giuseppe Gallone, David Heller, Knut Reinert, Stefan Haas, Martin Vingron
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007843 (2020)
Reconstructing haplotypes from sequencing data is one of the major challenges in genetics. Haplotypes play a crucial role in many analyses, including genome-wide association studies and population genetics. Haplotype reconstruction becomes more diffi
Externí odkaz:
https://doaj.org/article/fa3a7d2c32c746ac998c1762bf531048
Autor:
Natalie Witt, Sandro Andreotti, Anne Busch, Kerstin Neubert, Knut Reinert, Herbert Tomaso, David Meierhofer
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory met
Externí odkaz:
https://doaj.org/article/e693ea6ebe4a47c9ba99ca77afadbd45
Autor:
Kerstin Neubert, Eric Zuchantke, Robert Maximilian Leidenfrost, Röbbe Wünschiers, Josephine Grützke, Burkhard Malorny, Holger Brendebach, Sascha Al Dahouk, Timo Homeier, Helmut Hotzel, Knut Reinert, Herbert Tomaso, Anne Busch
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c6fa15ff0d7d41f5a0687fe17e401058
Autor:
Sandeep Keshavan, Fernando Torres Andón, Audrey Gallud, Wei Chen, Knut Reinert, Lang Tran, Bengt Fadeel
Publikováno v:
Nanomaterials, Vol 11, Iss 4, p 883 (2021)
Engineered nanomaterials are potentially very useful for a variety of applications, but studies are needed to ascertain whether these materials pose a risk to human health. Here, we studied three benchmark nanomaterials (Ag nanoparticles, TiO2 nanopa
Externí odkaz:
https://doaj.org/article/520d4726ebae496f9083a77b3503afba