Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Knut R Steffensen"'
Autor:
Rym Ghaddab-Zroud, Isabelle Seugnet, Knut R Steffensen, Barbara A Demeneix, Marie-Stéphanie Clerget-Froidevaux
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106983 (2014)
Reversing the escalating rate of obesity requires increased knowledge of the molecular mechanisms controlling energy balance. Liver X receptors (LXRs) and thyroid hormone receptors (TRs) are key physiological regulators of energetic metabolism. Analy
Externí odkaz:
https://doaj.org/article/71421671874c4583ab490b12c1e06d67
Autor:
Matteo Pedrelli, Padideh Davoodpour, Chiara Degirolamo, Monica Gomaraschi, Mark Graham, Alice Ossoli, Lilian Larsson, Laura Calabresi, Jan-Åke Gustafsson, Knut R Steffensen, Mats Eriksson, Paolo Parini
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93552 (2014)
OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC) to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affe
Externí odkaz:
https://doaj.org/article/84f8dce4f8ea4df6a4d1616d2b236234
Autor:
Nicholes R Candelaria, Sridevi Addanki, Jine Zheng, Trang Nguyen-Vu, Husna Karaboga, Prasenjit Dey, Chiara Gabbi, Lise-Lotte Vedin, Ka Liu, Wanfu Wu, Philip K Jonsson, Jean Z Lin, Fei Su, Lakshmi Reddy Bollu, Sally E Hodges, Amy L McElhany, Mehdi A Issazadeh, William E Fisher, Michael M Ittmann, Knut R Steffensen, Jan-Åke Gustafsson, Chin-Yo Lin
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106289 (2014)
Pancreatic ductal adenocarcinoma (PDAC) is difficult to detect early and is often resistant to standard chemotherapeutic options, contributing to extremely poor disease outcomes. Members of the nuclear receptor superfamily carry out essential biologi
Externí odkaz:
https://doaj.org/article/4b766a328e044a598a76bfafa68f8a91
Autor:
Juan Vladimir de la Rosa, Carlos Tabraue, Zhiqiang Huang, Marta C. Orizaola, Patricia Martin‐Rodríguez, Knut R. Steffensen, Juan Manuel Zapata, Lisardo Boscá, Peter Tontonoz, Susana Alemany, Eckardt Treuter, Antonio Castrillo
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Macrophages regulate essential aspects of innate immunity against pathogens. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. The liver X receptors (LXRα, L
Externí odkaz:
https://doaj.org/article/0d64bc9760874725979011a9fec830ac
Autor:
Jeroen F J Bogie, Silke Timmermans, Vân Anh Huynh-Thu, Alexandre Irrthum, Hubert J M Smeets, Jan-Åke Gustafsson, Knut R Steffensen, Monique Mulder, Piet Stinissen, Niels Hellings, Jerome J A Hendriks
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44998 (2012)
Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role. Foamy macrophages and microglia, containing degenerated myelin, are abundantly found in active
Externí odkaz:
https://doaj.org/article/5aafb65e5a5b4dbea6049ae2cc79c7b5
Autor:
Karine H Hellemans, Jean-Claude Hannaert, Bart Denys, Knut R Steffensen, Cindy Raemdonck, Geert A Martens, Paul P Van Veldhoven, Jan-Ake Gustafsson, Daniel Pipeleers
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7266 (2009)
Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased trigly
Externí odkaz:
https://doaj.org/article/139ce2ea13384226bea0bc3ef4a7c07d
Autor:
Christian Bindesbøll, Qiong Fan, Rikke C. Nørgaard, Laura MacPherson, Hai-Bin Ruan, Jing Wu, Thomas Å. Pedersen, Knut R. Steffensen, Xiaoyong Yang, Jason Matthews, Susanne Mandrup, Hilde I. Nebb, Line M. Grønning-Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 771-785 (2015)
Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP).
Externí odkaz:
https://doaj.org/article/ea74357040794890a9059321a49a7f5b
Autor:
Mirko E, Minniti, Matteo, Pedrelli, Lise-Lotte, Vedin, Anne-Sophie, Delbès, Raphaël G P, Denis, Katariina, Öörni, Claudia, Sala, Chiara, Pirazzini, Divya, Thiagarajan, Harri J, Nurmi, Markus, Grompe, Kevin, Mills, Paolo, Garagnani, Ewa C S, Ellis, Stephen C, Strom, Serge H, Luquet, Elizabeth M, Wilson, John, Bial, Knut R, Steffensen, Paolo, Parini
Publikováno v:
Hepatology (Baltimore, Md.)
Hepatology
Hepatology, Wiley-Blackwell, 2019, 72 (2), pp.656-670. ⟨10.1002/hep.31052⟩
Hepatology
Hepatology, Wiley-Blackwell, 2019, 72 (2), pp.656-670. ⟨10.1002/hep.31052⟩
International audience; Background and Aims; Genetically modified mice have been used extensively to study human disease. However, the data gained are not always translatable to humans because of major species differences. Liver‐humanized mice (LHM
Autor:
Camilla Pramfalk, Osman Ahmed, Matteo Pedrelli, Mirko E. Minniti, Serge Luquet, Raphaël GP Denis, Maria Olin, Jennifer Härdfeldt, Lise‐Lotte Vedin, Knut R Steffensen, Mikael Rydén, Leanne Hodson, Mats Eriksson, Paolo Parini
Publikováno v:
Journal of Internal Medicine
Journal of Internal Medicine, 2022, 292 (2), pp.296-307. ⟨10.1111/joim.13450⟩
Journal of Internal Medicine, Wiley, 2022, ⟨10.1111/joim.13450⟩
Journal of Internal Medicine, 2022, 292 (2), pp.296-307. ⟨10.1111/joim.13450⟩
Journal of Internal Medicine, Wiley, 2022, ⟨10.1111/joim.13450⟩
Background Sterol O-acyltransferase 2 (Soat2) encodes acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), which synthesizes cholesteryl esters in hepatocytes and enterocytes fated either to storage or to secretion into nascent triglyceride-rich li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a498e5a6c379f6674da4e11c943eaaa
https://ora.ox.ac.uk/objects/uuid:d668108a-b159-434e-a2b9-b2b8038e623d
https://ora.ox.ac.uk/objects/uuid:d668108a-b159-434e-a2b9-b2b8038e623d
Autor:
Piet Stinissen, Noam Zelcer, Erwin Wijnands, Silke Timmermans, Knut R. Steffensen, Katherine Nelissen, Jo Mailleux, Monique T. Mulder, Jasmine Vanmol, Kristiaan Wouters, Jan-Åke Gustafsson, Jeroen F. J. Bogie, Tim Vanmierlo, Jerome J. A. Hendriks
Publikováno v:
Journal of autoimmunity, 124:102723. Academic Press Inc.
Journal of Autoimmunity, 124:102723. Academic Press
Journal of Autoimmunity, 124:102723. Elsevier Science
Journal of Autoimmunity, 124:102723. Academic Press
Journal of Autoimmunity, 124:102723. Elsevier Science
The initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol m