Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Knut Pettersson"'
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Akademický článek
Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response
Autor: Rob C. M. de Jong, Niek J. Pluijmert, Margreet R. de Vries, Knut Pettersson, Douwe E. Atsma, J. Wouter Jukema, Paul H. A. Quax
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV
Externí odkaz: https://doaj.org/article/50bd8d889bfd42e0baca7bd420a4b082
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2
Akademický článek
Time-dependent changes to lipids and antioxidants in plasma and aortas of apolipoprotein E knockout mice
Autor: Jacinta M. Letters, Paul K. Witting, Julie K. Christison, Annika Weston Eriksson, Knut Pettersson, Roland Stocker
Publikováno v: Journal of Lipid Research, Vol 40, Iss 6, Pp 1104-1112 (1999)
Oxidation of lipoproteins is thought to be an early event in atherogenesis. To evaluate whether aortic lipoprotein lipid (per)oxidation contributes to atherosclerosis, we investigated the time-dependent changes to lipids and antioxidants in plasma an
Externí odkaz: https://doaj.org/article/2c3326c9175645af9d044cbce1e71e99
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3
Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts
Autor: Fabiana Baganha, Thijs J. Sluiter, Rob C. M. de Jong, Louise A. van Alst, Hendrika A. B. Peters, J. Wouter Jukema, Mirela Delibegovic, Knut Pettersson, Paul H. A. Quax, Margreet R. de Vries
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13662
International Journal of Molecular Sciences, 23(21). MDPI
Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by natural IgM antibodies and low levels of these antibodies have been associate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e224e87eaa483e2c309cedc49ec65e2b
https://doi.org/10.3390/ijms232113662
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4
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases
Autor: Ewa Ninio, J.W. Jukema, Erna Peters, James R. Mitchell, S.A.P. Karabina, Johan Frostegård, R.C.M. Jong, A. Bergman, Margreet R. de Vries, I. Dahlbom, Michael R MacArthur, M.M. Ewing, M. Nordzell, D.J. Sexton, J.C. Karper, Paul H.A. Quax, Knut Pettersson, J. Kuiper
Publikováno v: Journal of Internal Medicine, 290 (1)
Journal of Internal Medicine, 290(1), 141-156. WILEY
Journal of Internal Medicine
Journal of Internal Medicine, Wiley, 2020, ⟨10.1111/joim.13234⟩
Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated molecular pattern. Previous data have shown that natural IgM anti‐PC protects against cardiovascular disease. We aimed to develop a monoclonal PC IgG antibody
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63977bd8d6d72a00632bfb05a3ee8956
https://hdl.handle.net/20.500.11850/465611
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5
Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response
Autor: Douwe E. Atsma, J. Wouter Jukema, Rob C. M. de Jong, Margreet R. de Vries, Niek J. Pluijmert, Paul H.A. Quax, Knut Pettersson
Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 25(16), 7772-7782. WILEY
Journal of Cellular and Molecular Medicine, 25(16), 7772-7782. Wiley-Blackwell
Pluijmert, N J, de Jong, R C M, de Vries, M R, Pettersson, K, Atsma, D E, Jukema, J W & Quax, P H A 2021, ' Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response ', Journal of Cellular and Molecular Medicine, vol. 25, no. 16, pp. 7772-7782 . https://doi.org/10.1111/jcmm.16662
Phosphorylcholine is a pro‐inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC‐mAb) have anti‐inflammatory properties. In this study, we hypothesize that PC‐mAb treatment reduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa823e92692cfc5104a63efc6e45d1ae
https://pubmed.ncbi.nlm.nih.gov/34190404
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6
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular
Autor: Mia, Ståhle, Johanna M U, Silvola, Sanna, Hellberg, Margreet, de Vries, Paul H A, Quax, Jeffrey, Kroon, Petteri, Rinne, Alwin, de Jong, Heidi, Liljenbäck, Nina, Savisto, Anna, Wickman, Erik S G, Stroes, Seppo, Ylä-Herttuala, Pekka, Saukko, Tommy, Abrahamsson, Knut, Pettersson, Juhani, Knuuti, Anne, Roivainen, Antti, Saraste
Publikováno v: JACC: Basic to Translational Science
Visual Abstract
Highlights • Phosphorylcholine is a pro-inflammatory epitope in atherogenic oxidized phospholipids. • This study investigated effects of a novel monoclonal IgG1 antibody against PC on vascular function and atherosclerotic inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9fa5b18bff0c4642d1a9013fda1551a
https://pubmed.ncbi.nlm.nih.gov/32368695
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7
Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response
Autor: Niek J. Pluijmert, Margreet R. de Vries, J. Wouter Jukema, Paul H.A. Quax, Knut Pettersson, Rob C. M. de Jong, Douwe E. Atsma
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports, 8(1), 6753
Scientific Reports, 8
Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV) functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a196889bcab7b287d9798e796fc81b
https://doi.org/10.1038/s41598-018-25143-y
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