Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Knut Holthoff"'
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110997- (2024)
Summary: Recent advances in understanding how neuronal activity shapes developing brain circuits increasingly rely on Gi/o-dependent inhibitory chemogenetic tools (Gi-DREADDs). However, their mechanisms of action and efficacy in neurons with immature
Externí odkaz:
https://doaj.org/article/fbedcfadcefb4d94bb92f62bc8f006e7
Autor:
Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Jürgen Graf, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff, Manuel Teichert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination
Externí odkaz:
https://doaj.org/article/89b253e6788f4c7bad847a600e743e75
Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo
Autor:
Jürgen Graf, Vahid Rahmati, Myrtill Majoros, Otto W Witte, Christian Geis, Stefan J Kiebel, Knut Holthoff, Knut Kirmse
Publikováno v:
eLife, Vol 11 (2022)
Spontaneous correlated activity is a universal hallmark of immature neural circuits. However, the cellular dynamics and intrinsic mechanisms underlying network burstiness in the intact developing brain are largely unknown. Here, we use two-photon Ca2
Externí odkaz:
https://doaj.org/article/5a64059fe9df40bb9387c360249f5778
Autor:
Raphael A. Seidel, Marcel Ritter, Alexander Joerk, Stefan Kuschke, Niklas Langguth, Daniel Schulze, Helmar Görls, Michael Bauer, Otto W. Witte, Matthias Westerhausen, Knut Holthoff, Georg Pohnert
Publikováno v:
ACS Omega, Vol 5, Iss 34, Pp 21401-21411 (2020)
Externí odkaz:
https://doaj.org/article/4d27e343a7964ebca97575483eb9cc43
Autor:
Chuanqiang Zhang, Shang Yang, Tom Flossmann, Shiqiang Gao, Otto W. Witte, Georg Nagel, Knut Holthoff, Knut Kirmse
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-17 (2019)
Abstract Background Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved
Externí odkaz:
https://doaj.org/article/dedf05e071574388863de33eb49f735b
Autor:
Tom Flossmann, Thomas Kaas, Vahid Rahmati, Stefan J. Kiebel, Otto W. Witte, Knut Holthoff, Knut Kirmse
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3173-3182.e5 (2019)
Summary: Synchronized activity is a universal characteristic of immature neural circuits that is essential for their developmental refinement and strongly depends on GABAergic neurotransmission. A major subpopulation of GABA-releasing interneurons (I
Externí odkaz:
https://doaj.org/article/474b97f01b864a13990801356f936d6d
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 2, p e1004736 (2016)
Calcium imaging has been used as a promising technique to monitor the dynamic activity of neuronal populations. However, the calcium trace is temporally smeared which restricts the extraction of quantities of interest such as spike trains of individu
Externí odkaz:
https://doaj.org/article/f9edbec5df394fe7ad8a995babf242e6
Autor:
Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff, Manuel Teichert
Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems might combine such information. Here in mice we find that stimulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a15c0e63e9507fa3f9e3ae60c9f6b5f
https://doi.org/10.1101/2022.11.04.515161
https://doi.org/10.1101/2022.11.04.515161
Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo
Autor:
Vahid Rahmati, Jürgen Graf, Myrtill Majoros, Otto W Witte, Christian Geis, Stefan J Kiebel, Knut Holthoff, Knut Kirmse
Spontaneous correlated activity is a universal hallmark of immature neural circuits. However, the cellular dynamics and intrinsic mechanisms underlying network burstiness in the intact developing brain are largely unknown. Here, we use two-photon Ca2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e38b06097f518ac06353da574b16a4
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/30090
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/30090