Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Knut, Woltjen"'
Autor:
Ryo Niwa, Kouji Sakai, Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/1900e217806e4b18ac7ee70eb831f2c7
Autor:
Thomas L. Maurissen, Masahide Kawatou, Víctor López-Dávila, Kenji Minatoya, Jun K. Yamashita, Knut Woltjen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Disease modeling using human induced pluripotent stem cells (hiPSCs) from patients with genetic disease is a powerful approach for dissecting pathophysiology and drug discovery. Nevertheless, isogenic controls are required to precisely compa
Externí odkaz:
https://doaj.org/article/795017081c5941128821f664692cee1c
Autor:
Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi, Shinya Yamanaka
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-10 (2023)
Abstract Background Disease-specific induced pluripotent stem cells (iPSCs) are useful tools for pathological analysis and diagnosis of rare diseases. Given the limited available resources, banking such disease-derived iPSCs and promoting their wides
Externí odkaz:
https://doaj.org/article/4c2420d60fd14b7195ed6fa7be24a185
Autor:
Ryo Niwa, Kouji Sakai, Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, continues to spread around the world with serious cases and deaths. It has also been suggested that different genetic variants in the human genome affect b
Externí odkaz:
https://doaj.org/article/848a17b47661450f8d9a4795aaba1afe
Autor:
Shunsuke Kawasaki, Hiroki Ono, Moe Hirosawa, Takeru Kuwabara, Shunsuke Sumi, Suji Lee, Knut Woltjen, Hirohide Saito
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Translational modulation based on RNA-binding proteins can be used to construct artificial gene circuits, but RNA-binding proteins capable of regulating translation efficiently and orthogonally remain scarce. Here we report CARTRIDGE (Cas-Re
Externí odkaz:
https://doaj.org/article/560b9b361411466c97b94ab5b06a1f92
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107685- (2023)
Summary: Application of the tetracycline-inducible gene expression system (Tet-On) in human induced pluripotent stem cells (hiPSCs) has become a fundamental transgenic tool owing to its regulatable gene expression. One of the major hurdles in hiPSC a
Externí odkaz:
https://doaj.org/article/89b516878c2f48bcb49876c0f86b4a1d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The skin of mammals is a multilayered and multicellular tissue that forms an environmental barrier with key functions in protection, regulation, and sensation. While animal models have long served to study the basic functions of the skin in vivo, new
Externí odkaz:
https://doaj.org/article/2dfe0bb8b44d44cfa57980f6586ac96a
Autor:
Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and d
Externí odkaz:
https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
Autor:
Ryo Niwa, Kouji Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen
Publikováno v:
Frontiers in Cell & Developmental Biology; 2024, p1-12, 12p
Autor:
Nao Sankoda, Wataru Tanabe, Akito Tanaka, Hirofumi Shibata, Knut Woltjen, Tsutomu Chiba, Hironori Haga, Yoshiharu Sakai, Masaki Mandai, Takuya Yamamoto, Yasuhiro Yamada, Shinji Uemoto, Yoshiya Kawaguchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–co
Externí odkaz:
https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035