Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice.

Autor: Melo-Silva CR; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Knudson CJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Tang L; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Kafle S; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Springer LE; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Choi J; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Snyder CM; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Wang Y; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA., Kim SV; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Sigal LJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Publikováno v: Cells [Cells] 2023 May 08; Vol. 12 (9). Date of Electronic Publication: 2023 May 08.

Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes.

Autor: Melo-Silva CR; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Roman MI; Department of Physics, St. Joseph University, Philadelphia PA 19131, USA., Knudson CJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA; GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426, USA., Tang L; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA., Xu RH; Advanced RNA Vaccine Technologies, Inc., 12358 Parklawn Dr, North Bethesda, MD 20852, USA., Tassetto M; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA., Dolan P; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA; Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892-3210, USA., Andino R; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA., Sigal LJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: luis.sigal@jefferson.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Nov 22; Vol. 41 (8), pp. 111676.

Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection.

Autor: Knudson CJ; Department of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA., Alves-Peixoto P; Department of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga 4710-057, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal., Muramatsu H; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Stotesbury C; Department of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA., Tang L; Department of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA., Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Weissman D; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Pardi N; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sigal LJ; Department of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: luis.sigal@jefferson.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Sep 01; Vol. 29 (9), pp. 2769-2781. Date of Electronic Publication: 2021 May 14.

Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.

Autor: Ferez M; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA., Knudson CJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA., Lev A; Fox Chase Cancer Center, Philadelphia, PA., Wong EB; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA., Alves-Peixoto P; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA.; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.; Life and Health Sciences Research Institute/Research Group in Biomaterials, Biodegradables and Biomimetics-Portugal Government Associate Laboratory, Braga/Guimarães, Portugal., Tang L; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA., Stotesbury C; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA., Sigal LJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2021 May 03; Vol. 218 (5).

α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control.

Autor: Stotesbury C; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Alves-Peixoto P; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Montoya B; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Ferez M; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Nair S; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Snyder CM; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Zhang S; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Knudson CJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107., Sigal LJ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107 luis.sigal@jefferson.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Mar 15; Vol. 204 (6), pp. 1582-1591. Date of Electronic Publication: 2020 Feb 03.