Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Autor: Knudsen, JG, Hamilton, A, Ramracheya, R, Tarasov, AI, Brereton, M, Haythorne, E, Chibalina, MV, Spégel, P, Mulder, H, Zhang, Q, Ashcroft, FM, Adam, J, Rorsman, P

Publikováno v: Cell Metabolism

Summary Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to th

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https://pubmed.ncbi.nlm.nih.gov/30580375

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Nicotinic signaling stimulates glucagon secretion in mouse and human pancreatic α-cells.

Autor: Hamilton A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; Lund University Diabetes Centre, Unit of Molecular Metabolism, Clinical Research Centre, Malmö University Hospital, 20502 Malmö, Sweden.; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Zhang Q; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Gao R; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China., Hill T; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK., Salehi A; Lund University Diabetes Centre, Unit of Molecular Metabolism, Clinical Research Centre, Malmö University Hospital, 20502 Malmö, Sweden.; Institute of Neuroscience and Physiology, Department of Physiology, Metabolic Research Unit, University of Göteborg, Göteborg, Sweden., Knudsen JG; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Draper M; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK., Johnson PRV; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; Oxford National Institute for Health Research, Biomedical Research Centre, Oxford, UK., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; Institute of Neuroscience and Physiology, Department of Physiology, Metabolic Research Unit, University of Göteborg, Göteborg, Sweden.; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.; Oxford National Institute for Health Research, Biomedical Research Centre, Oxford, UK., Tarasov AI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. Churchill Hospital, Headington, OX3 7LE, Oxford, UK.; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.

Publikováno v: Diabetes [Diabetes] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.

Autor: Hill TG; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Gao R; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Benrick A; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Kothegala L; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.; Department of Developmental Biology and Genetics (DBG), Indian Institute of Science (IISc), Bengaluru, India., Rorsman N; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Santos C; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Acreman S; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Briant LJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Dou H; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Gandasi NR; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden.; Department of Developmental Biology and Genetics (DBG), Indian Institute of Science (IISc), Bengaluru, India., Guida C; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Haythorne E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Wallace M; Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, UK.; The Royal Veterinary College, Hatfield, Hertfordshire, UK., Knudsen JG; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Miranda C; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Tolö J; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden., Clark A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Davison L; Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, UK.; The Royal Veterinary College, Hatfield, Hertfordshire, UK., Størling J; Steno Diabetes Center Copenhagen, Translational Type 1 Diabetes Research, Herlev, Denmark., Tarasov A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Ashcroft FM; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. patrik.rorsman@drl.ox.ac.uk.; Metabolic Research Unit, Institute of Neuroscience and Physiology, University of Göteborg, Göteborg, Sweden. patrik.rorsman@drl.ox.ac.uk.; Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK. patrik.rorsman@drl.ox.ac.uk.; Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford, UK. patrik.rorsman@drl.ox.ac.uk., Zhang Q; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. quan.zhang@ocdem.ox.ac.uk.; Center for Neuroscience and Cell Biology (CNC), Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. quan.zhang@ocdem.ox.ac.uk.

Publikováno v: Nature metabolism [Nat Metab] 2024 Sep 23. Date of Electronic Publication: 2024 Sep 23.