Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Knud J, Jensen"'
Autor:
Freja Bohr, Søren S. -R. Bohr, Narendra Kumar Mishra, Nicolás Sebastian González-Foutel, Henrik Dahl Pinholt, Shunliang Wu, Emilie Milan Nielsen, Min Zhang, Magnus Kjaergaard, Knud J. Jensen, Nikos S. Hatzakis
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Single-molecule studies reveal the pathway organization of self-assembly and disassembly of insulin hexamers and how this is remodeled by regulatory cues and formulations. The abundance of all oligomeric species as well their kinetics are assessed.
Externí odkaz:
https://doaj.org/article/a2c4283706f740dcac2882e75c3bfc65
Autor:
Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou, Hanbin Mao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Chiral communication can propagate in secondary structures within the effective intermolecular force (IMF) range but it is not known whether long-range chiral communication exists between tertiary peptide structures. Here, the authors use single-mole
Externí odkaz:
https://doaj.org/article/1005fa8d3f614a3ba35af08e33c5fc2c
Autor:
Jannik B. Larsen, Kadla R. Rosholm, Celeste Kennard, Søren L. Pedersen, Henrik K. Munch, Vadym Tkach, John J. Sakon, Thomas Bjørnholm, Keith R. Weninger, Poul Martin Bendix, Knud J. Jensen, Nikos S Hatzakis, Mark J. Uline, Dimitrios Stamou
Publikováno v:
ACS Central Science, Vol 6, Iss 7, Pp 1159-1168 (2020)
Externí odkaz:
https://doaj.org/article/82b6e210065c4a9495803ea527e41d0e
Autor:
Shunliang Wu, Mads Østergaard, Freja Fredholt, Niels Johan Christensen, Kasper K. Sørensen, Narendra K. Mishra, Hanne M. Nielsen, Knud J. Jensen
Publikováno v:
Bioconjugate Chemistry. 34:518-528
Autor:
Manuel C. Martos-Maldonado, Christian T. Hjuler, Kasper K. Sørensen, Mikkel B. Thygesen, Jakob E. Rasmussen, Klaus Villadsen, Søren R. Midtgaard, Stefan Kol, Sanne Schoffelen, Knud J. Jensen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
His-tagged proteins can undergo N-terminal acylation as an undesired side-reaction. Here, the authors utilize this to develop a method for highly selective acylation and further modification of peptides and proteins using an optimized His sequence an
Externí odkaz:
https://doaj.org/article/3e78d4a3733a4cc3b314ad992f024827
Autor:
Gokce Engudar, Cristina Rodríguez-Rodríguez, Narendra Kumar Mishra, Marta Bergamo, Guillaume Amouroux, Knud J. Jensen, Katayoun Saatchi, Urs O. Häfeli
Publikováno v:
Journal of Controlled Release. 343:347-360
Human insulin (HI) has fascinating metal-facilitated self-assembly properties that are essential for its biological function. HI has a natural Zn
Autor:
Chenguang Lou, Manuel C. Martos-Maldonado, Charlotte S. Madsen, Rasmus P. Thomsen, Søren Roi Midtgaard, Niels Johan Christensen, Jørgen Kjems, Peter W. Thulstrup, Jesper Wengel, Knud J. Jensen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Peptide and oligonucleotide systems are known to self-assemble both in nature and artificial systems. Here, the authors combine both forms of self-assembly through the synthesis of peptideoligonucleotide conjugates and show formation of a three-helix
Externí odkaz:
https://doaj.org/article/bacb04f814c143a4bbd60f8011d53d2a
Autor:
Knud J. Jensen, Mikkel B. Thygesen, Kasper K. Sørensen, Shunliang Wu, Tuule Treiberg, Sanne Schoffelen
Publikováno v:
ChemBioChem. 23
The chemical modification of proteins is of great importance in chemical biology, biotechnology, and for the production of modified biopharmaceuticals, as it enables introduction of fluorophores, biotin, half-life extending moieties, and more. We hav
Autor:
Lisbeth Nielsen Fink, Nina Buch-Månson, Knud J. Jensen, Narendra Kumar Mishra, Niels Vrang, Søren L. Pedersen, Karin Mannerstedt, Keld Fosgerau, Thomas Brimert, Philip J. Pedersen, Priska Le-Huu, Charlotte Madsen, Ebbe Engholm, Björn Borgström, Morten Lundh
Publikováno v:
Chemistry – A European Journal. 27:3166-3176
A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linke
Autor:
Christian Kofoed, Shunliang Wu, Kasper K. Sørensen, Tuule Treiberg, Johnny Arnsdorf, Sara P. Bjørn, Tanja L. Jensen, Bjørn G. Voldborg, Mikkel B. Thygesen, Knud J. Jensen, Sanne Schoffelen
Publikováno v:
Kofoed, C, Wu, S, Sørensen, K K, Treiberg, T, Arnsdorf, J, Bjørn, S P, Jensen, T L, Voldborg, B G, Thygesen, M B, Jensen, K J & Schoffelen, S 2022, ' Highly Selective Lysine Acylation in Proteins Using a Lys-His Tag Sequence ', Chemistry: A European Journal, vol. 28, no. 15, e202200147 . https://doi.org/10.1002/chem.202200147
Kofoed, C, Wu, S, Sørensen, K K, Treiberg, T, Arnsdorf, J, Bjørn, S P, Jensen, T L, Voldborg, B G, Thygesen, M B, Jensen, K J & Schoffelen, S 2022, ' Highly selective lysine acylation in proteins using a Lys-His tag sequence ', Chemistry-A European Journal, vol. 28, no. 15 . https://doi.org/10.1002/chem.202200147
Kofoed, C, Wu, S, Sørensen, K K, Treiberg, T, Arnsdorf, J, Bjørn, S P, Jensen, T L, Voldborg, B G, Thygesen, M B, Jensen, K J & Schoffelen, S 2022, ' Highly selective lysine acylation in proteins using a Lys-His tag sequence ', Chemistry-A European Journal, vol. 28, no. 15 . https://doi.org/10.1002/chem.202200147
Chemical modification of proteins has numerous applications, but it has been challenging to achieve the required high degree of selectivity on lysine amino groups. Recently, we described the highly selective acylation of proteins with an N-terminal G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51595d1281f109d67226de44c10a40e4
https://curis.ku.dk/portal/da/publications/highly-selective-lysine-acylation-in-proteins-using-a-lyshis-tag-sequence(e5726e1f-758b-4b67-9a4d-0598a064138f).html
https://curis.ku.dk/portal/da/publications/highly-selective-lysine-acylation-in-proteins-using-a-lyshis-tag-sequence(e5726e1f-758b-4b67-9a4d-0598a064138f).html