Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Knowles, Tuomas PJ"'
The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the ability of existing aggregates to replicate is a key property in generating
Externí odkaz:
http://arxiv.org/abs/2008.09699
Publikováno v:
Biomacromolecules. 24:1709-1716
Funder: Frances and Augustus Newman Foundation
Funder: Biotechnology and Biological Sciences Research Council
Silk proteins obtained from the Bombyx mori silkworm have been extensively studied due to their remarkable mechanical properties.
Funder: Biotechnology and Biological Sciences Research Council
Silk proteins obtained from the Bombyx mori silkworm have been extensively studied due to their remarkable mechanical properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af24819d4832cccbd21981103f320a6a
https://doi.org/10.1021/acs.biomac.2c01479
https://doi.org/10.1021/acs.biomac.2c01479
Autor:
Jacquat, Raphaël PB, Krainer, Georg, Peter, Quentin AE, Babar, Ali Nawaz, Vanderpoorten, Oliver, Xu, Catherine K, Welsh, Timothy J, Kaminski, Clemens F, Keyser, Ulrich F, Baumberg, Jeremy J, Knowles, Tuomas PJ
Publikováno v:
Nano Letters. 23:1629-1636
An approach relying on nanocavity confinement is developed in this paper for the sizing of nanoscale particles and single biomolecules in solution. The approach, termed nanocavity diffusional sizing (NDS), measures particle residence times within nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525a1d1b13e062a005ead508b4d32ba6
https://doi.org/10.1021/acs.nanolett.1c04830
https://doi.org/10.1021/acs.nanolett.1c04830
Autor:
Toprakcioglu, Zenon, Wiita, Elizabeth G, Jayaram, Akhila K, Gregory, Rebecca C, Knowles, Tuomas PJ
Funder: Gates Cambridge Trust
Funder: Biotechnology and Biological Sciences Research Council
Funder: Centre for Misfolding Diseases, University of Cambridge
Funder: Frances and Augustus Newman Foundation
The rapid emergence of dru
Funder: Biotechnology and Biological Sciences Research Council
Funder: Centre for Misfolding Diseases, University of Cambridge
Funder: Frances and Augustus Newman Foundation
The rapid emergence of dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7a16053f37d00f996f3d14f2240fad
https://www.repository.cam.ac.uk/handle/1810/347042
https://www.repository.cam.ac.uk/handle/1810/347042
Autor:
Baumann, Kevin N, Šneiderienė, Greta, Sanguanini, Michele, Schneider, Matthias, Rimon, Oded, González Díaz, Alicia, Greer, Heather, Thacker, Dev, Linse, Sara, Knowles, Tuomas PJ, Vendruscolo, Michele
Funder: Cambridge Centre for Misfolding Disease
Funder: Wellcome Trust
Funder: Frances and Augustus Newman Foundation
Funder: Biotechnology and Biological Sciences Research Council
The aggregation of the amyloid β (Aβ) peptide i
Funder: Wellcome Trust
Funder: Frances and Augustus Newman Foundation
Funder: Biotechnology and Biological Sciences Research Council
The aggregation of the amyloid β (Aβ) peptide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bb95bbd8a46094b2a567aeb9bea6df
https://www.repository.cam.ac.uk/handle/1810/345878
https://www.repository.cam.ac.uk/handle/1810/345878
Autor:
Emin, Derya, Zhang, Yu P, Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I, Lam, Jeff YL, Ranasinghe, Rohan T, Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas PJ, Vendruscolo, Michele, Ruggeri, Francesco S, Aigbirhio, Franklin I, Williams-Gray, Caroline H, Klenerman, David
Funder: Royal Society
Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of different co-existing aggregate species makes it ha
Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of different co-existing aggregate species makes it ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131353908472ae35989cafd62a8d41a1
Funder: Frances and Augustus Newman Foundation
Funder: Laboratory for Molecular Cell Biology, University College London
Funder: Biotechnology and Biological Sciences Research Council
A self-consistent analytical solution for binodal co
Funder: Laboratory for Molecular Cell Biology, University College London
Funder: Biotechnology and Biological Sciences Research Council
A self-consistent analytical solution for binodal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af7adc68f28dd47a4d86f7d0a5fcd78
https://www.repository.cam.ac.uk/handle/1810/341128
https://www.repository.cam.ac.uk/handle/1810/341128
Autor:
Weiffert, Tanja, Meisl, Georg, Curk, Samo, Cukalevski, Risto, Šarić, Anđela, Knowles, Tuomas PJ, Linse, Sara
Peer reviewed: True
Amyloid formation is linked to devastating neurodegenerative diseases, motivating detailed studies of the mechanisms of amyloid formation. For Aβ, the peptide associated with Alzheimer's disease, the mechanism and rate of ag
Amyloid formation is linked to devastating neurodegenerative diseases, motivating detailed studies of the mechanisms of amyloid formation. For Aβ, the peptide associated with Alzheimer's disease, the mechanism and rate of ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6829269f4ba7203e3822b16aecaeadad
Autor:
Zhu, Hongjia, Roode, Lianne WY, Parry, Aled J, Erkamp, Nadia A, Rodriguez-Garcia, Marc, Narita, Masako, Shen, Yi, Ou, Yangteng, Toprakcioglu, Zenon, Narita, Masashi, Knowles, Tuomas PJ
Funder: H2020 European Research Council; Id: http://dx.doi.org/10.13039/100010663
Funder: China Scholarship
Funder: College of Engineering, University of Canterbury; Id: http://dx.doi.org/10.13039/100014447
Multicellular cancer spheroi
Funder: China Scholarship
Funder: College of Engineering, University of Canterbury; Id: http://dx.doi.org/10.13039/100014447
Multicellular cancer spheroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee62b52af94ac2279d5e427cd6f6b2
https://www.repository.cam.ac.uk/handle/1810/343480
https://www.repository.cam.ac.uk/handle/1810/343480
Through advances in the past decades, the central role of aberrant protein aggregation has been established in many neurodegenerative diseases. Crucially, however, the molecular mechanisms that underlie aggregate proliferation in the brains of affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9cf84b424f11ca006adc73ebd44d6d