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Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Autor: Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Ni?ankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group, BIOAIR (Longitudinal Assessment of Clinical Course, Biomarkers in Severe Chronic Airway Disease) Consortium.

Publikováno v: The European respiratory journal 59 (2022).
info:cnr-pdr/source/autori:Mikus MS; Kolmert J; Andersson LI; Östling J; Knowles RG; Gómez C; Ericsson M; Thörngren JO; Khoonsari PE; Dahlén B; Kupczyk M; De Meulder B; Auffray C; Bakke PS; Beghe B; Bel EH; Caruso M; Chanez P; Chawes B; Fowler SJ; Gaga M; Geiser T; Gjomarkaj M; Horváth I; Howarth PH; Johnston SL; Joos G; Krug N; Montuschi P; Musial J; Ni?ankowska-Mogilnicka E; Olsson HK; Papi A; Rabe KF; Sandström T; Shaw DE; Siafakas NM; Uhlen M; Riley JH; Bates S; Middelveld RJM; Wheelock CE; Chung KF; Adcock IM; Sterk PJ; Djukanovic R; Nilsson P; Dahlén SE; James A; U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium./titolo:Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation/doi:/rivista:The European respiratory journal/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:59

Rationale: Asthma phenotyping requires novel biomarker discovery. Objectives: To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterized cohorts of severe (SA) and mi

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