Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Autor: Witt, SH, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, CS, Treutlein, J, Degenhardt, F, Forstner, AJ, Heilmann-Heimbach, S, Dietl, L, Schwarze, CE, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, TM, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, OA, Babadjanova, G, Bass, NJ, Bauer, M, Baune, BT, Bellivier, F, Bergen, S, Bethell, A, Biernacka, JM, Blackwood, DHR, Boks, MP, Boomsma, DI, Børglum, AD, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschøn, HN, Byrne, EM, Cervantes, P, Clarke, T-K, Craddock, N, Cruceanu, C, Curtis, D, Czerski, PM, Dannlowski, U, Davis, T, de Geus, EJC, Di Florio, A, Djurovic, S, Domenici, E, Edenberg, HJ, Etain, B, Fischer, SB, Forty, L, Fraser, C, Frye, MA, Fullerton, JM, Gade, K, Gershon, ES, Giegling, I, Gordon, SD, Gordon-Smith, K, Grabe, HJ, Green, EK, Greenwood, TA, Grigoroiu-Serbanescu, M, Guzman-Parra, J, Hall, LS, Hamshere, M, Hauser, J, Hautzinger, M, Heilbronner, U, Herms, S, Hitturlingappa, S, Hoffmann, P, Holmans, P, Hottenga, J-J, Jamain, S, Jones, I, Jones, LA, Juréus, A, Kahn, RS, Kammerer-Ciernioch, J, Kirov, G, Kittel-Schneider, S, Kloiber, S, Knott, SV, Kogevinas, M, Landén, M, Leber, M, Leboyer, M, Li, QS, Lissowska, J, Lucae, S, Martin, NG, Mayoral-Cleries, F, McElroy, SL, McIntosh, AM, McKay, JD, McQuillin, A

Publikováno v: Translational psychiatry, vol 7, iss 6

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patien

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https://escholarship.org/uc/item/8vh6n3f1

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Autor: Witt SH; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Streit F; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Jungkunz M; Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Frank J; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Awasthi S; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany., Reinbold CS; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Treutlein J; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life and Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Forstner AJ; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life and Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, Bonn, Germany., Dietl L; Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany., Schwarze CE; Department of Clinical Psychology and Psychotherapy, University of Heidelberg, Heidelberg, Germany., Schendel D; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Strohmaier J; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Abdellaoui A; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Adolfsson R; Department of Clinical Sciences, Psychiatry, Umeå University, Umeå, Sweden., Air TM; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Akil H; Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Alda M; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Alliey-Rodriguez N; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Andreassen OA; Division Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT, University of Oslo, Oslo, Norway., Babadjanova G; Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation., Bass NJ; Division of Psychiatry, University College London, London, UK., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany., Baune BT; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Bellivier F; Inserm, U1144, AP-HP, GH Saint-Louis, Département de Psychiatrie et de Médecine Addictologique, Paris, France., Bergen S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bethell A; National Center for Mental Health, Cardiff University, Cardiff, UK., Biernacka JM; Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Blackwood DHR; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Boks MP; Urain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Børglum AD; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Borrmann-Hassenbach M; Medical and Quality Assurance, Clinics of Upper Bavaria, Munich, Germany., Brennan P; Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France., Budde M; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Germany.; Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany., Buttenschøn HN; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Byrne EM; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Cervantes P; Department of Psychiatry, McGill University, Montreal, QC, Canada., Clarke TK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Craddock N; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Cruceanu C; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Curtis D; Centre for Psychiatry, Queen Mary University of London, London, UK.; UCL Genetics Institute, University College London, London, UK., Czerski PM; Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Dannlowski U; Department of Psychiatry, University of Marburg, Marburg, Germany.; Department of Psychiatry, University of Münste, Münster, Germany., Davis T; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Di Florio A; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Djurovic S; Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway.; NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Domenici E; Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy., Edenberg HJ; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, Indianapolis, IN, USA.; Indiana University School of Medicine, Department of Medical and Molecular Genetics, Indianapolis, IN, USA., Etain B; Faculté de Médecine, Université Paris Est, Créteil, France., Fischer SB; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Forty L; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Fraser C; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Fullerton JM; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Sydney, NSW, Australia., Gade K; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Germany.; Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany., Gershon ES; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Giegling I; Department of Psychiatry, University of Halle, Halle, Germany., Gordon SD; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Gordon-Smith K; Department of Psychological Medicine, University of Worcester, Worcester, UK., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Green EK; School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK., Greenwood TA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., Guzman-Parra J; Mental Health Department, Biomedicine Institute, University Regional Hospital, Málaga, Spain., Hall LS; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK., Hamshere M; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Hauser J; Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Hautzinger M; Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany., Heilbronner U; Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany., Herms S; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life and Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Hitturlingappa S; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Hoffmann P; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life and Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Holmans P; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Jamain S; Faculté de Médecine, Université Paris Est, Créteil, France.; Inserm U955, Psychiatrie Translationnelle, Créteil, France., Jones I; National Center for Mental Health, Cardiff University, Cardiff, UK., Jones LA; Department of Psychological Medicine, University of Worcester, Worcester, UK., Juréus A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Kahn RS; University Medical Center Utrecht, Division of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands., Kammerer-Ciernioch J; Center of Psychiatry Weinsberg, Weinsberg, Germany., Kirov G; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Kloiber S; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Max Planck Institute of Psychiatry, Munich, Germany., Knott SV; Department of Psychological Medicine, University of Worcester, Worcester, UK., Kogevinas M; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain., Landén M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Leber M; Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany., Leboyer M; Inserm U955, Translational Psychiatry Laboratory, AP-HP, DHU PePSY, Department of Psychiatry, Université Paris Est, Créteil, France., Li QS; Janssen Research and Development, LLC, Neuroscience Therapeutic Area, Titusville, NJ, USA., Lissowska J; M. Sklodowska-Curie Cancer Center and Institute of Oncology, Cancer Epidemiology and Prevention, Warsaw, Poland., Lucae S; Max Planck Institute of Psychiatry, Munich, Germany., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Psychology, The University of Queensland, Brisbane, QLD, Australia., Mayoral-Cleries F; Mental Health Department, Biomedicine Institute, University Regional Hospital, Málaga, Spain., McElroy SL; Lindner Center of HOPE, Research Institute, Mason, OH, USA., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., McKay JD; Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France., McQuillin A; Division of Psychiatry, University College London, London, UK., Medland SE; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Middeldorp CM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Milaneschi Y; VU University Medical Center and GGZ inGeest, Department of Psychiatry, Amsterdam, The Netherlands., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Black Dog Institute, Sydney, NSW, Australia., Montgomery GW; Institute for Molecular Biology, University of Queensland, Brisbane, QLD, Australia., Morken G; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Psychiatry, St Olavs University Hospital, Trondheim, Norway., Mors O; Risskov, Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Mühleisen TW; Research Center Juelich, Institute of Neuroscience and Medicine (INM-1), Juelich, Germany.; Division of Medical Genetics, University of Basel, Basel, Switzerland., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; University of Liverpool, Liverpool, UK., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Nurnberger JI; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Loohuis LMO; Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA., Ophoff R; University Medical Center Utrecht, Division of Brain Research, Utrecht, The Netherlands., Oruc L; Psychiatry Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia-Herzegovina., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Paciga SA; Pfizer Global Research and Development, Human Genetics and Computational Biomedicine, Groton, CT, USA., Penninx BWJH; VU University Medical Center and GGZ inGeest, Department of Psychiatry, Amsterdam, The Netherlands., Perry A; Department of Psychological Medicine, University of Worcester, Worcester, UK., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany., Potash JB; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Preisig M; Department of Psychiatry, Psychiatric University Hospital of Lausanne, Lausanne, Switzerland., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Rivas F; Mental Health Department, Biomedicine Institute, University Regional Hospital, Málaga, Spain., Rouleau GA; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Montreal Neurological Institute and Hospital, Montreal, QC, Canada., Schofield PR; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Sydney, NSW, Australia., Schulze TG; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Germany.; Medical Center of the University of Munich, Campus Innenstadt, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.; NIMH Division of Intramural Research Programs, Human Genetics Branch, Bethesda, MD, USA., Schwarz M; Psychiatric Center Nordbaden, Wiesloch, Germany., Scott L; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Sinnamon GCB; School of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia., Stahl EA; Broad Institute of MIT and Harvard, Medical and Population Genetics, Cambridge, MA, USA.; Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Strauss J; Centre for Addiction and Mental Health, Toronto, ON, Canada., Turecki G; Department of Psychiatry, McGill University, Montreal, QC, Canada., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Vedder H; Psychiatric Center Nordbaden, Wiesloch, Germany., Vincent JB; Centre for Addiction and Mental Health, Molecular Neuropsychiatry and Development Laboratory, Toronto, ON, Canada., Willemsen G; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Witt CC; Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Wray NR; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Xi HS; Pfizer Global Research and Development, Computational Sciences Center of Emphasis, Cambridge, MA, USA., Tadic A; AGAPLESION Elisabethenstift gGmbh, Department of Psychiatry, Psychosomatics and Psychotherapy, Darmstadt, Germany.; University Medical Center, Department of Psychiatry and Psychotherapy, Mainz, Germany., Dahmen N; University Medical Center, Department of Psychiatry and Psychotherapy, Mainz, Germany., Schott BH; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.; Leibniz Institute for Neurobiology, Magdeburg, Germany., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Research Center Juelich, Institute of Neuroscience and Medicine (INM-1), Juelich, Germany.; Division of Medical Genetics, University of Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life and Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.; Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Mobascher A; University Medical Center, Department of Psychiatry and Psychotherapy, Mainz, Germany., Rujescu D; Department of Psychiatry, University of Halle, Halle, Germany., Lieb K; University Medical Center, Department of Psychiatry and Psychotherapy, Mainz, Germany., Roepke S; Department of Psychiatry, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany., Schmahl C; Central Institute of Mental Health, Clinic of Psychosomatic and Psychotherapeutic Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Bohus M; Central Institute of Mental Health, Institute for Psychiatric and Psychosomatic Psychotherapy (IPPP)/Psychosomatic Medicine and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Rietschel M; Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2017 Jun 20; Vol. 7 (6), pp. e1155. Date of Electronic Publication: 2017 Jun 20.