Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Autor: Wang, J, Wegener, JE, Huang, TW, Sripathy, S, De Jesus-Cortes, H, Xu, P, Tran, S, Knobbe, W, Leko, V, Britt, J, Starwalt, R, McDaniel, L, Ward, CS, Parra, D, Newcomb, B, Lao, U, Nourigat, C, Flowers, DA, Cullen, S, Jorstad, NL, Yang, Y, Glaskova, L, Vigneau, S, Kozlitina, J, Yetman, MJ, Jankowsky, JL, Reichardt, SD, Reichardt, HM, Gärtner, J, Bartolomei, MS, Fang, M, Loeb, K, Keene, CD, Bernstein, I, Goodell, M, Brat, DJ, Huppke, P, Neul, JL, Bedalov, A, Pieper, AA

Publikováno v: Nature, vol 521, iss 7552
Wang, J; Wegener, JE; Huang, TW; Sripathy, S; De Jesus-Cortes, H; Xu, P; et al.(2015). Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature, 521(7552), E1-E4. doi: 10.1038/nature14444. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/54q747sf

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the X chromosomal gene Methyl-CpG-binding Protein 2 (MECP2) (1). RTT treatment so far is symptomatic. Mecp2 disruption in mice phenocopies major features of the syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a2edf02023e95369f081fde02877b6da
https://escholarship.org/uc/item/54q747sf

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

Autor: Lee AS; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York, New York 10065; Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, Cornell University, New York, New York 10065., De Jesús-Cortés H; Neuroscience Graduate Program, UT Southwestern Medical Center, Dallas, Texas 75390; Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242., Kabir ZD; Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine , Cornell University, New York, New York 10065., Knobbe W; Department of Psychiatry, UT Southwestern Medical Center , Dallas, Texas 75390., Orr M; Department of Psychiatry, UT Southwestern Medical Center , Dallas, Texas 75390., Burgdorf C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York, New York 10065; Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, Cornell University, New York, New York 10065., Huntington P; Department of Psychiatry, UT Southwestern Medical Center , Dallas, Texas 75390., McDaniel L; Department of Psychiatry, University of Iowa , Carver College of Medicine , Iowa City, Iowa 52242., Britt JK; Department of Psychiatry, University of Iowa , Carver College of Medicine , Iowa City, Iowa 52242., Hoffmann F; Institute of Pharmacology, Technical University Munich, Munich, Germany; Research Group 923, Technical University Munich, Munich, Germany., Brat DJ; Pathology and Laboratory Medicine, Emory University School of Medicine , Atlanta, Georgia 30322., Rajadhyaksha AM; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York, New York 10065; Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, Cornell University, New York, New York 10065; Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065., Pieper AA; Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065; Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Department of Free Radical and Radiation Biology Program, Department of Radiation Oncology Holden Comprehensive Cancer Center, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242; Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.

Publikováno v: ENeuro [eNeuro] 2016 Mar 31; Vol. 3 (2). Date of Electronic Publication: 2016 Mar 31 (Print Publication: 2016).

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Autor: Wang J; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Wegener JE; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany., Huang TW; 1] Jan and Dan Duncan Neurological Research Institute (Texas Children's Hospital), Baylor College of Medicine, Houston, Texas 77030, USA [2] Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA., Sripathy S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., De Jesus-Cortes H; 1] Graduate Program of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA., Xu P; Graduate Program of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Tran S; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Knobbe W; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Leko V; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Britt J; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA., Starwalt R; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., McDaniel L; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA., Ward CS; Jan and Dan Duncan Neurological Research Institute (Texas Children's Hospital), Baylor College of Medicine, Houston, Texas 77030, USA., Parra D; Jan and Dan Duncan Neurological Research Institute (Texas Children's Hospital), Baylor College of Medicine, Houston, Texas 77030, USA., Newcomb B; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Lao U; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Nourigat C; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Flowers DA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Cullen S; Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA., Jorstad NL; Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Yang Y; Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Glaskova L; Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Vingeau S, Kozlitina J; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Yetman MJ; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA., Jankowsky JL; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA., Reichardt SD; Institute for Cellular and Molecular Immunology; University of Göttingen Medical School, Humboldtallee 34, 37073 Göttingen, Germany., Reichardt HM; Institute for Cellular and Molecular Immunology; University of Göttingen Medical School, Humboldtallee 34, 37073 Göttingen, Germany., Gärtner J; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany., Bartolomei MS; Department of Cell &Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Fang M; 1] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA [2] Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Loeb K; 1] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA [2] Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Keene CD; Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA., Bernstein I; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Goodell M; 1] Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA [2] Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA [3] Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA [4] Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas 77030, USA [5] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA [6] Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas 77030, USA., Brat DJ; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA., Huppke P; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany., Neul JL; 1] Jan and Dan Duncan Neurological Research Institute (Texas Children's Hospital), Baylor College of Medicine, Houston, Texas 77030, USA [2] Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA [3] Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA [4] Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA [5] Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas 77030, USA [6] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA., Bedalov A; 1] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA [2] Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105, USA., Pieper AA; 1] Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [2] Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [3] Veterans Affairs, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA [4] Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065, USA.

Publikováno v: Nature [Nature] 2015 May 21; Vol. 521 (7552), pp. E1-4.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Autor: Tesla R; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Oct 16; Vol. 109 (42), pp. 17016-21. Date of Electronic Publication: 2012 Oct 01.

Nanotechnology‐empowered therapeutics targeting neurodegenerative diseases.

Autor: Wang, Zhiren, Gonzalez, Karina Marie, Cordova, Leyla Estrella, Lu, Jianqin

Publikováno v: WIREs: Nanomedicine & Nanobiotechnology; Sep2023, Vol. 15 Issue 5, p1-33, 33p