Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin

Autor: Bott, RK, Beckmann, K, Zylstra, J, Wilkinson, MJ, Knight, WRC, Baker, CR, Kelly, M, Maisey, N, Qureshi, A, Sevitt, T, Van Hemelrijck, M, Smyth, EC, Allum, WH, Lagergren, J, Gossage, JA, Cunningham, D, Davies, AR, Guy's and St Thomas' Oesophagogastric Research Group

BACKGROUND: The role of adjuvant therapy in patients with oesophagogastric adenocarcinoma treated by neoadjuvant chemotherapy is contentious. In UK practice, surgical resection margin status is often used to classify patients for receiving adjuvant t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3564a74d38cc47e7f1349c5be80da80e

Predicting response to neoadjuvant chemotherapy in patients with oesophageal adenocarcinoma.

Autor: Bott RK; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., George G; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), King's College London, London, UK., McEwen R; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK., Zylstra J; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK., Knight WRC; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Baker CR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Kelly M; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Griffin N; Department of Radiology, St Thomas' Hospital, London, UK., McAddy N; Department of Radiology, St Thomas' Hospital, London, UK., Maisey N; Department of Medical Oncology, Guy's Hospital London, London, UK., Van Hemelrijck M; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), King's College London, London, UK., Gossage JA; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Lagergren J; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Davies AR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

Publikováno v: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2021 Dec; Vol. 60 (12), pp. 1629-1636. Date of Electronic Publication: 2021 Oct 06.

Adjuvant therapy following neoadjuvant chemotherapy and surgery for oesophageal adenocarcinoma in patients with clear resection margins.

Autor: Bott RK; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Beckmann K; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), King's College London, London, UK.; University of South Australia Cancer Research Institute, University of South Australia, Adelaide, Australia., Zylstra J; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK., Wilkinson MJ; Department of Upper Gastrointestinal Surgery, The Royal Marsden Hospital, London, UK., Knight WRC; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Baker CR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Kelly M; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Maisey N; Department of Medical Oncology, Guy's Hospital, London, UK., Waters J; Department of Medical Oncology, Maidstone Hospital, Kent, UK., Van Hemelrijck M; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research (TOUR), King's College London, London, UK., Smyth EC; Department of Medical Oncology, The Royal Marsden Hospital, London, UK., Allum WH; Department of Upper Gastrointestinal Surgery, The Royal Marsden Hospital, London, UK., Lagergren J; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Gossage JA; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Cunningham D; Department of Medical Oncology, The Royal Marsden Hospital, London, UK., Davies AR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital, London, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

Publikováno v: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2021 May; Vol. 60 (5), pp. 672-680. Date of Electronic Publication: 2021 Feb 15.

Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin.

Autor: Bott RK; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital.; School of Cancer and Pharmaceutical Sciences., Beckmann K; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research, King's College London, London, UK.; University of South Australia Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia., Zylstra J; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital., Wilkinson MJ; Departments of Upper Gastrointestinal Surgery, London, UK., Knight WRC; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital., Baker CR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital.; School of Cancer and Pharmaceutical Sciences., Kelly M; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital.; School of Cancer and Pharmaceutical Sciences., Maisey N; Departments of Medical Oncology, London, UK., Qureshi A; Clinical Oncology, Guy's Hospital, London, UK., Sevitt T; Department of Medical Oncology, Maidstone Hospital, Maidstone, UK., Van Hemelrijck M; School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology Research, King's College London, London, UK., Smyth EC; Medical Oncology, Royal Marsden Hospital, London, UK., Allum WH; Departments of Upper Gastrointestinal Surgery, London, UK., Lagergren J; School of Cancer and Pharmaceutical Sciences.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Gossage JA; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital.; School of Cancer and Pharmaceutical Sciences., Cunningham D; Medical Oncology, Royal Marsden Hospital, London, UK., Davies AR; Department of Upper Gastrointestinal and General Surgery, St Thomas' Hospital.; School of Cancer and Pharmaceutical Sciences.

Publikováno v: The British journal of surgery [Br J Surg] 2020 Dec; Vol. 107 (13), pp. 1801-1810. Date of Electronic Publication: 2020 Sep 29.

Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus.

Autor: Knight WRC; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London., Yip C; School of Biomedical Engineering and Imaging Sciences, King's College London., Wulaningsih W; Cancer Epidemiology and Population Health Associated Research Group, King's College London., Jacques A; Department of Radiology, Guy's and St Thomas' Hospital, London, UK., Griffin N; Department of Radiology, Guy's and St Thomas' Hospital, London, UK., Zylstra J; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London., Van Hemelrijck M; Cancer Epidemiology and Population Health Associated Research Group, King's College London., Maisey N; Department of Oncology, Guy's and St Thomas' Hospital, London, UK., Gaya A; Department of Oncology, Guy's and St Thomas' Hospital, London, UK., Baker CR; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London., Kelly M; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London., Gossage JA; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Lagergren J; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Landau D; Department of Oncology, Guy's and St Thomas' Hospital, London, UK., Goh V; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London., Davies AR; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Ngan S; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Qureshi A; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Deere H; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Green M; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Chang F; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Mahadeva U; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Gill-Barman B; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., George S; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Dunn J; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Zeki S; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Meenan J; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Hynes O; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Tham G; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Iezzi C; Department of Surgery, Guy's and St Thomas' Oesophago-Gastric Centre, King's College London.; School of Cancer and Pharmaceutical Sciences, King's College London.; School of Biomedical Engineering and Imaging Sciences, King's College London.; Cancer Epidemiology and Population Health Associated Research Group, King's College London.; Department of Radiology, Guy's and St Thomas' Hospital, London, UK.; Department of Oncology, Guy's and St Thomas' Hospital, London, UK.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: BJS open [BJS Open] 2019 Aug 22; Vol. 3 (6), pp. 767-776. Date of Electronic Publication: 2019 Aug 22 (Print Publication: 2019).