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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.

Autor: Carzaniga L; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Linney ID; Medicinal Chemistry Department, Charles River, Chesterford Research Park, Saffron Walden, CB10 1XL Essex, United Kingdom., Rizzi A; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Delcanale M; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Schmidt W; Medicinal Chemistry Department, Charles River, Chesterford Research Park, Saffron Walden, CB10 1XL Essex, United Kingdom., Knight CK; Medicinal Chemistry Department, Charles River, Chesterford Research Park, Saffron Walden, CB10 1XL Essex, United Kingdom., Pastore F; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Miglietta D; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Carnini C; Project Leader, Corporate Drug Development, Chiesi Farmaceutici S.p.A Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Cesari N; Pharmacokinetics Biochemistry and Metabolism Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Riccardi B; Pharmacokinetics Biochemistry and Metabolism Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Mileo V; Analytics and Early Formulation Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Venturi L; Analytics and Early Formulation Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Moretti E; Analytics and Early Formulation Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Blackaby WP; Medicinal Chemistry Department, Charles River, Chesterford Research Park, Saffron Walden, CB10 1XL Essex, United Kingdom., Patacchini R; Project Leader, Corporate Drug Development, Chiesi Farmaceutici S.p.A Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Accetta A; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Biagetti M; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Bassani F; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Tondelli M; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Murgo A; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Battipaglia L; Safety & Toxicology Department, Chiesi Farmaceutici S.p.A Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Villetti G; Pharmacology Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Puccini P; Pharmacokinetics Biochemistry and Metabolism Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Catinella S; Analytics and Early Formulation Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Civelli M; Head of Global Research & Preclinical Development, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy., Rancati F; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Research Center, Largo Belloli 11/a, 43122 Parma, Italy.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Aug 11; Vol. 65 (15), pp. 10233-10250. Date of Electronic Publication: 2022 Jul 28.

Household food insecurity and medication "scrimping" among US adults with diabetes.

Autor: Knight CK; South Carolina Department of Health and Environmental Control, United States. Electronic address: chadwick159@hotmail.com., Probst JC; Department of Health Services Policy and Management, Arnold School of Public Health, 915 Greene Street, Room 355, University of South Carolina, Columbia, SC 29208, United States., Liese AD; Department of Epidemiology and Biostatistics, Arnold School of Public Health, 915 Greene Street, Room 461, University of South Carolina, Columbia, SC 29208, United States., Sercye E; Cancer Prevention and Control Program, Arnold School of Public Health, 915 Greene Street, Room 249, University of South Carolina, Columbia, SC 29208, United States., Jones SJ; Department of Health Promotion, Education and Behavior, Arnold School of Public Health, 915 Greene Street, Room 435B, University of South Carolina, Columbia, SC 29208, United States.

Publikováno v: Preventive medicine [Prev Med] 2016 Feb; Vol. 83, pp. 41-5. Date of Electronic Publication: 2015 Dec 04.

Pectenotoxin-2 synthetic studies. 3. Assessment of the capacity for stereocontrolled cyclization to form the entire C1-C26 subunit based upon the double bond geometry across C15-C16.

Autor: O'Connor PD; Evans Chemical Laboratories, The Ohio State University, Columbus, OH 43210-1185, USA., Knight CK, Friedrich D, Peng X, Paquette LA

Publikováno v: The Journal of organic chemistry [J Org Chem] 2007 Mar 02; Vol. 72 (5), pp. 1747-54. Date of Electronic Publication: 2007 Feb 02.